Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration

Abstract There has been increasing interest in finding non-invasive biomarkers for neurodegenerative diseases such as Alzheimer’s disease (AD). This observational study investigated AD-specific biomarkers in tear fluid. Tear fluid was collected from a total of 65 subjects, including 23 patients with...

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Autores principales:	Marlies Gijs, Inez H. G. B. Ramakers, Pieter Jelle Visser, Frans R. J. Verhey, Marjo P. H. van de Waarenburg, Casper G. Schalkwijk, Rudy M. M. A. Nuijts, Carroll A. B. Webers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0259775b371840b5a3af84478f3ec598
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spelling	oai:doaj.org-article:0259775b371840b5a3af84478f3ec5982021-11-28T12:21:34ZAssociation of tear fluid amyloid and tau levels with disease severity and neurodegeneration10.1038/s41598-021-01993-x2045-2322https://doaj.org/article/0259775b371840b5a3af84478f3ec5982021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01993-xhttps://doaj.org/toc/2045-2322Abstract There has been increasing interest in finding non-invasive biomarkers for neurodegenerative diseases such as Alzheimer’s disease (AD). This observational study investigated AD-specific biomarkers in tear fluid. Tear fluid was collected from a total of 65 subjects, including 23 patients with subjective cognitive decline (SCD), 22 patients with mild cognitive impairment (MCI), 11 dementia patients and 9 healthy controls (HC). Levels of amyloid-beta peptides (AB38, AB40, AB42), total-tau (t-tau) and phosphorylated-tau (p-tau) were determined using multiplex immunoassays. Levels of AB40 and t-tau were detectable in the vast majority (> 94%) of tear fluid samples. Cerebrospinal fluid (CSF) was available from a subset of patients. In this group, tear t-tau levels were significantly higher in people with dementia compared to SCD patients. Tear t-tau levels were elevated in patients with neurodegeneration (classified according to the A/T/N system) compared to patients without neurodegeneration. Negative correlations were found between CSF AB42 and CSF t-tau, and between CSF AB42 and tear t-tau. In summary, this study shows the potential of tau proteins in tear fluid to be associated with disease severity and neurodegeneration.Marlies GijsInez H. G. B. RamakersPieter Jelle VisserFrans R. J. VerheyMarjo P. H. van de WaarenburgCasper G. SchalkwijkRudy M. M. A. NuijtsCarroll A. B. WebersNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marlies Gijs Inez H. G. B. Ramakers Pieter Jelle Visser Frans R. J. Verhey Marjo P. H. van de Waarenburg Casper G. Schalkwijk Rudy M. M. A. Nuijts Carroll A. B. Webers Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration
description	Abstract There has been increasing interest in finding non-invasive biomarkers for neurodegenerative diseases such as Alzheimer’s disease (AD). This observational study investigated AD-specific biomarkers in tear fluid. Tear fluid was collected from a total of 65 subjects, including 23 patients with subjective cognitive decline (SCD), 22 patients with mild cognitive impairment (MCI), 11 dementia patients and 9 healthy controls (HC). Levels of amyloid-beta peptides (AB38, AB40, AB42), total-tau (t-tau) and phosphorylated-tau (p-tau) were determined using multiplex immunoassays. Levels of AB40 and t-tau were detectable in the vast majority (> 94%) of tear fluid samples. Cerebrospinal fluid (CSF) was available from a subset of patients. In this group, tear t-tau levels were significantly higher in people with dementia compared to SCD patients. Tear t-tau levels were elevated in patients with neurodegeneration (classified according to the A/T/N system) compared to patients without neurodegeneration. Negative correlations were found between CSF AB42 and CSF t-tau, and between CSF AB42 and tear t-tau. In summary, this study shows the potential of tau proteins in tear fluid to be associated with disease severity and neurodegeneration.
format	article
author	Marlies Gijs Inez H. G. B. Ramakers Pieter Jelle Visser Frans R. J. Verhey Marjo P. H. van de Waarenburg Casper G. Schalkwijk Rudy M. M. A. Nuijts Carroll A. B. Webers
author_facet	Marlies Gijs Inez H. G. B. Ramakers Pieter Jelle Visser Frans R. J. Verhey Marjo P. H. van de Waarenburg Casper G. Schalkwijk Rudy M. M. A. Nuijts Carroll A. B. Webers
author_sort	Marlies Gijs
title	Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration
title_short	Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration
title_full	Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration
title_fullStr	Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration
title_full_unstemmed	Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration
title_sort	association of tear fluid amyloid and tau levels with disease severity and neurodegeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0259775b371840b5a3af84478f3ec598
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Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration

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