Analysis of macular cone photoreceptors in a case of occult macular dystrophy

Naoki Tojo Tomoko Nakamura Hironori Ozaki Miyako Oka Toshihiko Oiwake Atsushi HayashiDepartment of Ophthalmology, University of Toyama, Toyama, JapanPurpose: To investigate changes in cone photoreceptors with adaptive optics (AO) fundus imaging and spectral domain optical coherence tomography (SD-OC...

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Autores principales:	Tojo N, Nakamura T, Ozaki H, Oka M, Oiwake T, Hayashi A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/025a122996da4c8aba69624dacce815c
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spelling	oai:doaj.org-article:025a122996da4c8aba69624dacce815c2021-12-02T00:05:31ZAnalysis of macular cone photoreceptors in a case of occult macular dystrophy1177-54671177-5483https://doaj.org/article/025a122996da4c8aba69624dacce815c2013-05-01T00:00:00Zhttp://www.dovepress.com/analysis-of-macular-cone-photoreceptors-in-a-case-of-occult-macular-dy-a12991https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Naoki Tojo Tomoko Nakamura Hironori Ozaki Miyako Oka Toshihiko Oiwake Atsushi HayashiDepartment of Ophthalmology, University of Toyama, Toyama, JapanPurpose: To investigate changes in cone photoreceptors with adaptive optics (AO) fundus imaging and spectral domain optical coherence tomography (SD-OCT) in a case of occult macular dystrophy (OMD).Patient and methods: Both eyes of a 42-year-old woman diagnosed with OMD were examined. We used an AO fundus camera to obtain images of cone photoreceptors in the macula of the OMD subject and five healthy control subjects. Correlations between the AO images and the SD-OCT images were examined. Cone photoreceptors in eight areas in the macula of OMD and healthy control subjects were analyzed and compared.Results: SD-OCT showed a loss of the cone outer-segment tips line outside of the fovea in both eyes of the subject with OMD. The left eye with decreased visual acuity showed a discontinuous photoreceptor inner-segment and outer-segment line and cone outer-segment tips line at the fovea in SD-OCT and loss of cone mosaics as a dark spot in the AO image. In panoramic AO images and cone-density maps, less cone density was observed in a ring-like region outside the fovea than in the peripheral retina. In most of the areas examined, the cone densities were lower in the OMD eyes than in the healthy control eyes.Conclusions: Cone densities in the macula of the OMD patient were greatly decreased. AO images were found to be useful to evaluate morphologic changes in cone photoreceptors in patients with OMD.Keywords: occult macular dystrophy, adaptive optics, cone photoreceptor, cone analysis, optical coherence tomographyTojo NNakamura TOzaki HOka MOiwake THayashi ADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 859-864 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Tojo N Nakamura T Ozaki H Oka M Oiwake T Hayashi A Analysis of macular cone photoreceptors in a case of occult macular dystrophy
description	Naoki Tojo Tomoko Nakamura Hironori Ozaki Miyako Oka Toshihiko Oiwake Atsushi HayashiDepartment of Ophthalmology, University of Toyama, Toyama, JapanPurpose: To investigate changes in cone photoreceptors with adaptive optics (AO) fundus imaging and spectral domain optical coherence tomography (SD-OCT) in a case of occult macular dystrophy (OMD).Patient and methods: Both eyes of a 42-year-old woman diagnosed with OMD were examined. We used an AO fundus camera to obtain images of cone photoreceptors in the macula of the OMD subject and five healthy control subjects. Correlations between the AO images and the SD-OCT images were examined. Cone photoreceptors in eight areas in the macula of OMD and healthy control subjects were analyzed and compared.Results: SD-OCT showed a loss of the cone outer-segment tips line outside of the fovea in both eyes of the subject with OMD. The left eye with decreased visual acuity showed a discontinuous photoreceptor inner-segment and outer-segment line and cone outer-segment tips line at the fovea in SD-OCT and loss of cone mosaics as a dark spot in the AO image. In panoramic AO images and cone-density maps, less cone density was observed in a ring-like region outside the fovea than in the peripheral retina. In most of the areas examined, the cone densities were lower in the OMD eyes than in the healthy control eyes.Conclusions: Cone densities in the macula of the OMD patient were greatly decreased. AO images were found to be useful to evaluate morphologic changes in cone photoreceptors in patients with OMD.Keywords: occult macular dystrophy, adaptive optics, cone photoreceptor, cone analysis, optical coherence tomography
format	article
author	Tojo N Nakamura T Ozaki H Oka M Oiwake T Hayashi A
author_facet	Tojo N Nakamura T Ozaki H Oka M Oiwake T Hayashi A
author_sort	Tojo N
title	Analysis of macular cone photoreceptors in a case of occult macular dystrophy
title_short	Analysis of macular cone photoreceptors in a case of occult macular dystrophy
title_full	Analysis of macular cone photoreceptors in a case of occult macular dystrophy
title_fullStr	Analysis of macular cone photoreceptors in a case of occult macular dystrophy
title_full_unstemmed	Analysis of macular cone photoreceptors in a case of occult macular dystrophy
title_sort	analysis of macular cone photoreceptors in a case of occult macular dystrophy
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/025a122996da4c8aba69624dacce815c
work_keys_str_mv	AT tojon analysisofmacularconephotoreceptorsinacaseofoccultmaculardystrophy AT nakamurat analysisofmacularconephotoreceptorsinacaseofoccultmaculardystrophy AT ozakih analysisofmacularconephotoreceptorsinacaseofoccultmaculardystrophy AT okam analysisofmacularconephotoreceptorsinacaseofoccultmaculardystrophy AT oiwaket analysisofmacularconephotoreceptorsinacaseofoccultmaculardystrophy AT hayashia analysisofmacularconephotoreceptorsinacaseofoccultmaculardystrophy
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Analysis of macular cone photoreceptors in a case of occult macular dystrophy

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