Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North

Scientific medical literature has accumulated a lot of data suggesting most important components of coronary heart disease pathogenesis and hypertension to be complex triggering processes of neuro-immune and neuro-endocrine interactions. Risk factors for cardiovascular diseases at the initial stages...

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Autores principales:	A. V. Gertsev, Yu. N. Zakrevskii, V. N. Ischuk
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	neuropeptide-cytokine status ischemic heart disease hypertension atherosclerosis anxiety-depressive disorders p-endorphin cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/025ac9827a774657b13f648cb8f4bdad
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spelling	oai:doaj.org-article:025ac9827a774657b13f648cb8f4bdad2021-11-18T08:03:51ZEfficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North1563-06252313-741X10.15789/1563-0625-EVF-2160https://doaj.org/article/025ac9827a774657b13f648cb8f4bdad2021-06-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2191https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XScientific medical literature has accumulated a lot of data suggesting most important components of coronary heart disease pathogenesis and hypertension to be complex triggering processes of neuro-immune and neuro-endocrine interactions. Risk factors for cardiovascular diseases at the initial stages of atherosclerosis formation cause endothelial dysfunction and trigger a cascade of immune inflammation in coronary vessels, which is based on shifting immune response towards activation of lymphocytes, with predominance of cellular immune reactions. As a rule, it results in remodeling of the vascular wall under participation of proinflammatory cytokines, shifting blood lipid balance towards atherogenicity, destabilization of atherosclerotic plaque, development of thrombosis and acute coronary syndrome. In this respect, the aim of our work was to develop treatment methods that allow, under participation of endogenous immune regulators, to change the structure of pro-atherogenic links via their interactions at the initial stages of the atherosclerotic lesion formation in chronic coronary heart disease and hypertension.To achieve this goal, 80 patients (men) were selected among the marine specialists of the ship crews serving in the Arctic latitudes and the Far North, with ischemic heart disease, stage 1 hypertension and astheno-neurotic disorders with anxiety and depressive manifestations. The groups of patients were formed as follows: Group 1 (n = 31, patients who received standard therapy with cardiotropic drugs; Group 2 (n = 29), subjects who underwent drug correction with weak tranquilizers as a part of standard cardiotropic therapy; Group 3 (n = 34), standard therapy accompanied by medical and psychological rehabilitation and digital psychophysiological therapy. Effectiveness of the treatment was studied by assessing the dynamics of parameters characterizing the neuropeptide-cytokine immune status, the markers used in the diagnostics of atherosclerosis, as well as paired relationships between them. The laboratory part of the work was represented by a set of diagnostic kits, including markers of atherosclerotic process, and test systems for determination of β-endorphin, proinflammatory cytokines (TNF α, IL-1 β, IL-6), and anti-inflammatory (IL-4, IL-10) spectrum.We have found that the use of medical and psychological rehabilitation, along with digital psychophysiological therapy contributes to optimization of neuropeptide-cytokine interactions, thus showing efficiency of cardiotropic drugs usage. It seems to correct the relationships within proatherogenic structures of immune system and pathogenetic links involved in development of atherosclerotic process in polymorbid cardiovascular pathology from marine specialists with intense workloads.A. V. GertsevYu. N. ZakrevskiiV. N. IschukSPb RAACIarticleneuropeptide-cytokine statusischemic heart diseasehypertensionatherosclerosisanxiety-depressive disordersp-endorphincytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 3, Pp 541-556 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	neuropeptide-cytokine status ischemic heart disease hypertension atherosclerosis anxiety-depressive disorders p-endorphin cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	neuropeptide-cytokine status ischemic heart disease hypertension atherosclerosis anxiety-depressive disorders p-endorphin cytokines Immunologic diseases. Allergy RC581-607 A. V. Gertsev Yu. N. Zakrevskii V. N. Ischuk Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North
description	Scientific medical literature has accumulated a lot of data suggesting most important components of coronary heart disease pathogenesis and hypertension to be complex triggering processes of neuro-immune and neuro-endocrine interactions. Risk factors for cardiovascular diseases at the initial stages of atherosclerosis formation cause endothelial dysfunction and trigger a cascade of immune inflammation in coronary vessels, which is based on shifting immune response towards activation of lymphocytes, with predominance of cellular immune reactions. As a rule, it results in remodeling of the vascular wall under participation of proinflammatory cytokines, shifting blood lipid balance towards atherogenicity, destabilization of atherosclerotic plaque, development of thrombosis and acute coronary syndrome. In this respect, the aim of our work was to develop treatment methods that allow, under participation of endogenous immune regulators, to change the structure of pro-atherogenic links via their interactions at the initial stages of the atherosclerotic lesion formation in chronic coronary heart disease and hypertension.To achieve this goal, 80 patients (men) were selected among the marine specialists of the ship crews serving in the Arctic latitudes and the Far North, with ischemic heart disease, stage 1 hypertension and astheno-neurotic disorders with anxiety and depressive manifestations. The groups of patients were formed as follows: Group 1 (n = 31, patients who received standard therapy with cardiotropic drugs; Group 2 (n = 29), subjects who underwent drug correction with weak tranquilizers as a part of standard cardiotropic therapy; Group 3 (n = 34), standard therapy accompanied by medical and psychological rehabilitation and digital psychophysiological therapy. Effectiveness of the treatment was studied by assessing the dynamics of parameters characterizing the neuropeptide-cytokine immune status, the markers used in the diagnostics of atherosclerosis, as well as paired relationships between them. The laboratory part of the work was represented by a set of diagnostic kits, including markers of atherosclerotic process, and test systems for determination of β-endorphin, proinflammatory cytokines (TNF α, IL-1 β, IL-6), and anti-inflammatory (IL-4, IL-10) spectrum.We have found that the use of medical and psychological rehabilitation, along with digital psychophysiological therapy contributes to optimization of neuropeptide-cytokine interactions, thus showing efficiency of cardiotropic drugs usage. It seems to correct the relationships within proatherogenic structures of immune system and pathogenetic links involved in development of atherosclerotic process in polymorbid cardiovascular pathology from marine specialists with intense workloads.
format	article
author	A. V. Gertsev Yu. N. Zakrevskii V. N. Ischuk
author_facet	A. V. Gertsev Yu. N. Zakrevskii V. N. Ischuk
author_sort	A. V. Gertsev
title	Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North
title_short	Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North
title_full	Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North
title_fullStr	Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North
title_full_unstemmed	Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North
title_sort	efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the far north
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/025ac9827a774657b13f648cb8f4bdad
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