Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus

Lin Zhu,1 Bo Yang,2 Dongxia Ma,3 Lan Wang,4 Wu Duan5 1Department of Pediatrics, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China; 2Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, H...

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Autores principales:	Zhu L, Yang B, Ma D, Wang L, Duan W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	hydrogen sulfide adipose tissue diabetes mellitus drug therapy Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/025b095c16a64277aa33a7fa3a76ae9f
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spelling	oai:doaj.org-article:025b095c16a64277aa33a7fa3a76ae9f2021-12-02T08:36:24ZHydrogen Sulfide, Adipose Tissue and Diabetes Mellitus1178-7007https://doaj.org/article/025b095c16a64277aa33a7fa3a76ae9f2020-06-01T00:00:00Zhttps://www.dovepress.com/hydrogen-sulfide-adipose-tissue-and-diabetes-mellitus-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Lin Zhu,1 Bo Yang,2 Dongxia Ma,3 Lan Wang,4 Wu Duan5 1Department of Pediatrics, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China; 2Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China; 3Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 4Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China; 5Division of Endocrinology, Department of Internal Medicine, Qilu Hospital of Shandong University, Jinan 250012, People’s Republic of ChinaCorrespondence: Wu DuanDivision of Endocrinology, Department of Internal Medicine, Qilu Hospital of Shandong University, Jinan 250012, People’s Republic of ChinaTel/ Fax +86-531-8692-7544Email duan5wu@qq.comAbstract: Hydrogen sulfide (H2S) is now increasingly considered to be the third gasotransmitter alongside other gaseous signaling molecules, nitric oxide (NO) and carbon monoxide (CO). H2S is produced by a variety of endogenous enzymatic and non-enzymatic pathways and acts as a modulator of the physiological and pathological events of the body. Adipocytes express the cystathionine γ lyase (CSE)/H2S system, which modulates a variety of biological activities in adipose tissue (AT), including inflammation, apoptosis, insulin resistance, adipokine secretion and adipocyte differentiation. Abnormalities in the physiological functions of AT play an important role in the process of diabetes mellitus. Therefore, this review provides an overview of the general aspects of H2S biochemistry, the effect of H2S on AT function and diabetes mellitus and its molecular signalling mechanisms as well as the potential application of H2S in pharmacotherapy.Keywords: hydrogen sulfide, adipose tissue, diabetes mellitus, drug therapyZhu LYang BMa DWang LDuan WDove Medical Pressarticlehydrogen sulfideadipose tissuediabetes mellitusdrug therapySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1873-1886 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	hydrogen sulfide adipose tissue diabetes mellitus drug therapy Specialties of internal medicine RC581-951
spellingShingle	hydrogen sulfide adipose tissue diabetes mellitus drug therapy Specialties of internal medicine RC581-951 Zhu L Yang B Ma D Wang L Duan W Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus
description	Lin Zhu,1 Bo Yang,2 Dongxia Ma,3 Lan Wang,4 Wu Duan5 1Department of Pediatrics, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China; 2Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China; 3Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 4Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China; 5Division of Endocrinology, Department of Internal Medicine, Qilu Hospital of Shandong University, Jinan 250012, People’s Republic of ChinaCorrespondence: Wu DuanDivision of Endocrinology, Department of Internal Medicine, Qilu Hospital of Shandong University, Jinan 250012, People’s Republic of ChinaTel/ Fax +86-531-8692-7544Email duan5wu@qq.comAbstract: Hydrogen sulfide (H2S) is now increasingly considered to be the third gasotransmitter alongside other gaseous signaling molecules, nitric oxide (NO) and carbon monoxide (CO). H2S is produced by a variety of endogenous enzymatic and non-enzymatic pathways and acts as a modulator of the physiological and pathological events of the body. Adipocytes express the cystathionine γ lyase (CSE)/H2S system, which modulates a variety of biological activities in adipose tissue (AT), including inflammation, apoptosis, insulin resistance, adipokine secretion and adipocyte differentiation. Abnormalities in the physiological functions of AT play an important role in the process of diabetes mellitus. Therefore, this review provides an overview of the general aspects of H2S biochemistry, the effect of H2S on AT function and diabetes mellitus and its molecular signalling mechanisms as well as the potential application of H2S in pharmacotherapy.Keywords: hydrogen sulfide, adipose tissue, diabetes mellitus, drug therapy
format	article
author	Zhu L Yang B Ma D Wang L Duan W
author_facet	Zhu L Yang B Ma D Wang L Duan W
author_sort	Zhu L
title	Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus
title_short	Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus
title_full	Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus
title_fullStr	Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus
title_full_unstemmed	Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus
title_sort	hydrogen sulfide, adipose tissue and diabetes mellitus
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/025b095c16a64277aa33a7fa3a76ae9f
work_keys_str_mv	AT zhul hydrogensulfideadiposetissueanddiabetesmellitus AT yangb hydrogensulfideadiposetissueanddiabetesmellitus AT mad hydrogensulfideadiposetissueanddiabetesmellitus AT wangl hydrogensulfideadiposetissueanddiabetesmellitus AT duanw hydrogensulfideadiposetissueanddiabetesmellitus
_version_	1718398445312540672

Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus

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