Association between baseline serum uric acid and development of LDL-C level in patients with first acute myocardial infarction

Abstract Background Data on the relationship of baseline serum uric acid (SUA) with development of low-density lipoprotein cholesterol (LDL-C) level in patients with first acute myocardial infarction (AMI) are limited. The present study is to evaluate whether elevated SUA predicts the development of...

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Autores principales:	Yang Chen, Congcong Ding, Longlong Hu, Yuehua Ruan, Kai Zou, Cong Dai, Yanhui Liao, Hanhui Liao, Yi Xia, Yuanbin Zhao, Renqiang Yang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Uric acid Low-density lipoprotein cholesterol Acute myocardial infarction Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/0261ac967d414d6b96d91b82cdf21570
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spelling	oai:doaj.org-article:0261ac967d414d6b96d91b82cdf215702021-12-05T12:05:14ZAssociation between baseline serum uric acid and development of LDL-C level in patients with first acute myocardial infarction10.1186/s12872-021-02383-x1471-2261https://doaj.org/article/0261ac967d414d6b96d91b82cdf215702021-11-01T00:00:00Zhttps://doi.org/10.1186/s12872-021-02383-xhttps://doaj.org/toc/1471-2261Abstract Background Data on the relationship of baseline serum uric acid (SUA) with development of low-density lipoprotein cholesterol (LDL-C) level in patients with first acute myocardial infarction (AMI) are limited. The present study is to evaluate whether elevated SUA predicts the development of LDL-C in the first AMI. Methods This is a retrospective 6-month cohort study of 475 hospitalized Chinese patients who underwent first AMI between January 2015 and December 2019 and were reevaluated half a year later at the Department of Cardiology, the Second Affiliated Hospital of Nanchang University, Jiangxi Province, China. The associations of baseline SUA with the percentage decrease of LDL-C (%) and LDL-C control were analyzed by using logistic regression analyses, multivariate linear regression analyses and the restricted cubic spline. Results Over the 6-month follow-up, baseline SUA was independently and positively associated with the percentage decrease of LDL-C (%) and LDL-C control in a dose response fashion. After multivariable adjustment, per SD increment of baseline SUA (120.58 μmol/L) was associated with 3.96% higher percentage decrease of LDL-C(%). The adjusted OR (95% CI) for LDL-C control was 5.62 (2.05, 15.36) when comparing the highest tertile (SUA ≥ 437.0 μmol/L) to the lowest tertile (< 341.7 μmol/L) of baseline SUA. Conclusions Among Chinese patients with first AMI, higher baseline SUA was associated with higher LDL-C deduction percentage (%), and higher rate of LDL-C control in the short-term follow-up, respectively. SUA acquired when AMI occurred was prone to be profitable in predicting the risk stratification of uncontrolled LDL-C and dyslipidemia management.Yang ChenCongcong DingLonglong HuYuehua RuanKai ZouCong DaiYanhui LiaoHanhui LiaoYi XiaYuanbin ZhaoRenqiang YangBMCarticleUric acidLow-density lipoprotein cholesterolAcute myocardial infarctionDiseases of the circulatory (Cardiovascular) systemRC666-701ENBMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Uric acid Low-density lipoprotein cholesterol Acute myocardial infarction Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Uric acid Low-density lipoprotein cholesterol Acute myocardial infarction Diseases of the circulatory (Cardiovascular) system RC666-701 Yang Chen Congcong Ding Longlong Hu Yuehua Ruan Kai Zou Cong Dai Yanhui Liao Hanhui Liao Yi Xia Yuanbin Zhao Renqiang Yang Association between baseline serum uric acid and development of LDL-C level in patients with first acute myocardial infarction
description	Abstract Background Data on the relationship of baseline serum uric acid (SUA) with development of low-density lipoprotein cholesterol (LDL-C) level in patients with first acute myocardial infarction (AMI) are limited. The present study is to evaluate whether elevated SUA predicts the development of LDL-C in the first AMI. Methods This is a retrospective 6-month cohort study of 475 hospitalized Chinese patients who underwent first AMI between January 2015 and December 2019 and were reevaluated half a year later at the Department of Cardiology, the Second Affiliated Hospital of Nanchang University, Jiangxi Province, China. The associations of baseline SUA with the percentage decrease of LDL-C (%) and LDL-C control were analyzed by using logistic regression analyses, multivariate linear regression analyses and the restricted cubic spline. Results Over the 6-month follow-up, baseline SUA was independently and positively associated with the percentage decrease of LDL-C (%) and LDL-C control in a dose response fashion. After multivariable adjustment, per SD increment of baseline SUA (120.58 μmol/L) was associated with 3.96% higher percentage decrease of LDL-C(%). The adjusted OR (95% CI) for LDL-C control was 5.62 (2.05, 15.36) when comparing the highest tertile (SUA ≥ 437.0 μmol/L) to the lowest tertile (< 341.7 μmol/L) of baseline SUA. Conclusions Among Chinese patients with first AMI, higher baseline SUA was associated with higher LDL-C deduction percentage (%), and higher rate of LDL-C control in the short-term follow-up, respectively. SUA acquired when AMI occurred was prone to be profitable in predicting the risk stratification of uncontrolled LDL-C and dyslipidemia management.
format	article
author	Yang Chen Congcong Ding Longlong Hu Yuehua Ruan Kai Zou Cong Dai Yanhui Liao Hanhui Liao Yi Xia Yuanbin Zhao Renqiang Yang
author_facet	Yang Chen Congcong Ding Longlong Hu Yuehua Ruan Kai Zou Cong Dai Yanhui Liao Hanhui Liao Yi Xia Yuanbin Zhao Renqiang Yang
author_sort	Yang Chen
title	Association between baseline serum uric acid and development of LDL-C level in patients with first acute myocardial infarction
title_short	Association between baseline serum uric acid and development of LDL-C level in patients with first acute myocardial infarction
title_full	Association between baseline serum uric acid and development of LDL-C level in patients with first acute myocardial infarction
title_fullStr	Association between baseline serum uric acid and development of LDL-C level in patients with first acute myocardial infarction
title_full_unstemmed	Association between baseline serum uric acid and development of LDL-C level in patients with first acute myocardial infarction
title_sort	association between baseline serum uric acid and development of ldl-c level in patients with first acute myocardial infarction
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0261ac967d414d6b96d91b82cdf21570
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Association between baseline serum uric acid and development of LDL-C level in patients with first acute myocardial infarction

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