Diabetes and Psoriasis: Different Sides of the Same Prism

Rachel Abramczyk,1 Jenna N Queller,2 Amy W Rachfal,3 Stanley S Schwartz4,5 1Main Line Health System, Wynnewood, PA, USA; 2Private Practice, Boca Raton, FL, USA; 3Stage Gate Partners, LLC, Ardmore, PA, USA; 4Stanley Schwartz, LLC, Main Line Health System, Ardmore, PA, USA; 5University of Pennsylvania...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Abramczyk R, Queller JN, Rachfal AW, Schwartz SS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	genes epigenetics inflammation abnormal environment insulin resistance Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/026465d784344851a9b22459c786bef3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:026465d784344851a9b22459c786bef3
record_format	dspace
spelling	oai:doaj.org-article:026465d784344851a9b22459c786bef32021-12-02T11:25:09ZDiabetes and Psoriasis: Different Sides of the Same Prism1178-7007https://doaj.org/article/026465d784344851a9b22459c786bef32020-10-01T00:00:00Zhttps://www.dovepress.com/diabetes-and-psoriasis-different-sides-of-the-same-prism-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Rachel Abramczyk,1 Jenna N Queller,2 Amy W Rachfal,3 Stanley S Schwartz4,5 1Main Line Health System, Wynnewood, PA, USA; 2Private Practice, Boca Raton, FL, USA; 3Stage Gate Partners, LLC, Ardmore, PA, USA; 4Stanley Schwartz, LLC, Main Line Health System, Ardmore, PA, USA; 5University of Pennsylvania, Philadelphia, PA, USACorrespondence: Stanley S SchwartzStanley Schwartz, MD, LLC, 233 E Lancaster Ave, Suite 305, Ardmore, PA 19003, USATel/Fax +1 610 642 6850Email stschwar@gmail.comAbstract: Diabetes and psoriasis are prevalent conditions with a spectrum of serious adverse outcomes. Both diseases are common comorbidities for each other, and diabetes is considered as a risk factor for psoriasis and vice versa. However, it is our contention that these diseases are not merely comorbidities of each other but rather share common underlying pathophysiologies (ie, genes and epigenetic changes, inflammation, abnormal environment, and insulin resistance) that drive disease. As such, they can be viewed as facets of the same prism. Genes can cause or permit susceptibility to damage from abnormal external and internal environmental factors, inflammation, and insulin resistance which can also drive epigenetic changes. These co-existing mechanisms act in a vicious cycle over time to potentiate cell and tissue damage to ultimately drive disease. Viewing diabetes and psoriasis through the same prism suggests potential for therapies that could be used to treat both conditions. Although additional controlled trials and research are warranted, we believe that our understanding of the overlapping pathophysiologies continues to grow, so too will our therapeutic options.Keywords: genes, epigenetics, inflammation, abnormal environment, insulin resistanceAbramczyk RQueller JNRachfal AWSchwartz SSDove Medical Pressarticlegenesepigeneticsinflammationabnormal environmentinsulin resistanceSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3571-3577 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	genes epigenetics inflammation abnormal environment insulin resistance Specialties of internal medicine RC581-951
spellingShingle	genes epigenetics inflammation abnormal environment insulin resistance Specialties of internal medicine RC581-951 Abramczyk R Queller JN Rachfal AW Schwartz SS Diabetes and Psoriasis: Different Sides of the Same Prism
description	Rachel Abramczyk,1 Jenna N Queller,2 Amy W Rachfal,3 Stanley S Schwartz4,5 1Main Line Health System, Wynnewood, PA, USA; 2Private Practice, Boca Raton, FL, USA; 3Stage Gate Partners, LLC, Ardmore, PA, USA; 4Stanley Schwartz, LLC, Main Line Health System, Ardmore, PA, USA; 5University of Pennsylvania, Philadelphia, PA, USACorrespondence: Stanley S SchwartzStanley Schwartz, MD, LLC, 233 E Lancaster Ave, Suite 305, Ardmore, PA 19003, USATel/Fax +1 610 642 6850Email stschwar@gmail.comAbstract: Diabetes and psoriasis are prevalent conditions with a spectrum of serious adverse outcomes. Both diseases are common comorbidities for each other, and diabetes is considered as a risk factor for psoriasis and vice versa. However, it is our contention that these diseases are not merely comorbidities of each other but rather share common underlying pathophysiologies (ie, genes and epigenetic changes, inflammation, abnormal environment, and insulin resistance) that drive disease. As such, they can be viewed as facets of the same prism. Genes can cause or permit susceptibility to damage from abnormal external and internal environmental factors, inflammation, and insulin resistance which can also drive epigenetic changes. These co-existing mechanisms act in a vicious cycle over time to potentiate cell and tissue damage to ultimately drive disease. Viewing diabetes and psoriasis through the same prism suggests potential for therapies that could be used to treat both conditions. Although additional controlled trials and research are warranted, we believe that our understanding of the overlapping pathophysiologies continues to grow, so too will our therapeutic options.Keywords: genes, epigenetics, inflammation, abnormal environment, insulin resistance
format	article
author	Abramczyk R Queller JN Rachfal AW Schwartz SS
author_facet	Abramczyk R Queller JN Rachfal AW Schwartz SS
author_sort	Abramczyk R
title	Diabetes and Psoriasis: Different Sides of the Same Prism
title_short	Diabetes and Psoriasis: Different Sides of the Same Prism
title_full	Diabetes and Psoriasis: Different Sides of the Same Prism
title_fullStr	Diabetes and Psoriasis: Different Sides of the Same Prism
title_full_unstemmed	Diabetes and Psoriasis: Different Sides of the Same Prism
title_sort	diabetes and psoriasis: different sides of the same prism
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/026465d784344851a9b22459c786bef3
work_keys_str_mv	AT abramczykr diabetesandpsoriasisdifferentsidesofthesameprism AT quellerjn diabetesandpsoriasisdifferentsidesofthesameprism AT rachfalaw diabetesandpsoriasisdifferentsidesofthesameprism AT schwartzss diabetesandpsoriasisdifferentsidesofthesameprism
_version_	1718395918505476096

Diabetes and Psoriasis: Different Sides of the Same Prism

Ejemplares similares