Histone variant H2A.Z regulates zygotic genome activation

During embryogenesis, the genome becomes transcriptionally active in a process known as zygotic genome activation (ZGA); how ZGA is initiated is still an open question. Here the authors show histone variant H2A.Z deposition precedes RNA polymerase II binding on chromatin, before ZGA. H2A.Z loss caus...

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Autores principales:	Dafne Ibarra-Morales, Michael Rauer, Piergiuseppe Quarato, Leily Rabbani, Fides Zenk, Mariana Schulte-Sasse, Francesco Cardamone, Alejandro Gomez-Auli, Germano Cecere, Nicola Iovino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0266ce08d5fc4cb9bd1de6a83d2425e9
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spelling	oai:doaj.org-article:0266ce08d5fc4cb9bd1de6a83d2425e92021-12-05T12:22:34ZHistone variant H2A.Z regulates zygotic genome activation10.1038/s41467-021-27125-72041-1723https://doaj.org/article/0266ce08d5fc4cb9bd1de6a83d2425e92021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27125-7https://doaj.org/toc/2041-1723During embryogenesis, the genome becomes transcriptionally active in a process known as zygotic genome activation (ZGA); how ZGA is initiated is still an open question. Here the authors show histone variant H2A.Z deposition precedes RNA polymerase II binding on chromatin, before ZGA. H2A.Z loss causes transcriptional downregulation of ZGA genes and leads to changes in the 3D genome organization.Dafne Ibarra-MoralesMichael RauerPiergiuseppe QuaratoLeily RabbaniFides ZenkMariana Schulte-SasseFrancesco CardamoneAlejandro Gomez-AuliGermano CecereNicola IovinoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dafne Ibarra-Morales Michael Rauer Piergiuseppe Quarato Leily Rabbani Fides Zenk Mariana Schulte-Sasse Francesco Cardamone Alejandro Gomez-Auli Germano Cecere Nicola Iovino Histone variant H2A.Z regulates zygotic genome activation
description	During embryogenesis, the genome becomes transcriptionally active in a process known as zygotic genome activation (ZGA); how ZGA is initiated is still an open question. Here the authors show histone variant H2A.Z deposition precedes RNA polymerase II binding on chromatin, before ZGA. H2A.Z loss causes transcriptional downregulation of ZGA genes and leads to changes in the 3D genome organization.
format	article
author	Dafne Ibarra-Morales Michael Rauer Piergiuseppe Quarato Leily Rabbani Fides Zenk Mariana Schulte-Sasse Francesco Cardamone Alejandro Gomez-Auli Germano Cecere Nicola Iovino
author_facet	Dafne Ibarra-Morales Michael Rauer Piergiuseppe Quarato Leily Rabbani Fides Zenk Mariana Schulte-Sasse Francesco Cardamone Alejandro Gomez-Auli Germano Cecere Nicola Iovino
author_sort	Dafne Ibarra-Morales
title	Histone variant H2A.Z regulates zygotic genome activation
title_short	Histone variant H2A.Z regulates zygotic genome activation
title_full	Histone variant H2A.Z regulates zygotic genome activation
title_fullStr	Histone variant H2A.Z regulates zygotic genome activation
title_full_unstemmed	Histone variant H2A.Z regulates zygotic genome activation
title_sort	histone variant h2a.z regulates zygotic genome activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0266ce08d5fc4cb9bd1de6a83d2425e9
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_version_	1718371997577117696

Histone variant H2A.Z regulates zygotic genome activation

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