Histone variant H2A.Z regulates zygotic genome activation

Histone variant H2A.Z regulates zygotic genome activation

During embryogenesis, the genome becomes transcriptionally active in a process known as zygotic genome activation (ZGA); how ZGA is initiated is still an open question. Here the authors show histone variant H2A.Z deposition precedes RNA polymerase II binding on chromatin, before ZGA. H2A.Z loss caus...

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Autores principales: Dafne Ibarra-Morales, Michael Rauer, Piergiuseppe Quarato, Leily Rabbani, Fides Zenk, Mariana Schulte-Sasse, Francesco Cardamone, Alejandro Gomez-Auli, Germano Cecere, Nicola Iovino
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/0266ce08d5fc4cb9bd1de6a83d2425e9
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