GluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders

In the mammalian brain, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) play a fundamental role in the activation of excitatory synaptic transmission and the induction of different forms of synaptic plasticity. The modulation of the AMPAR tetramer subuni...

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Autores principales:	Maria Italia, Elena Ferrari, Monica Di Luca, Fabrizio Gardoni
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	AMPA receptors Synaptic plasticity Synaptic transmission Autoimmunity Neurodegeneration Glutamate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/0270aa965eae488389c05376df29e190
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spelling	oai:doaj.org-article:0270aa965eae488389c05376df29e1902021-12-04T04:33:08ZGluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders1095-953X10.1016/j.nbd.2021.105539https://doaj.org/article/0270aa965eae488389c05376df29e1902021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0969996121002886https://doaj.org/toc/1095-953XIn the mammalian brain, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) play a fundamental role in the activation of excitatory synaptic transmission and the induction of different forms of synaptic plasticity. The modulation of the AMPAR tetramer subunit composition at synapses defines the functional properties of the receptor. During the last twenty years, several studies have evaluated the roles played by each subunit, from GluA1 to GluA4, in both physiological and pathological conditions. Here, we have focused our attention on GluA3-containing AMPARs, addressing their functional role in synaptic transmission and synaptic plasticity and their involvement in a variety of brain disorders.Although several aspects remain to be fully understood, GluA3 is a widely expressed and functionally relevant subunit in AMPARs involved in several brain circuits, and its pharmacological modulation could represent a novel approach for the rescue of altered glutamatergic synapses associated with neurodegenerative and neurodevelopmental disorders.Maria ItaliaElena FerrariMonica Di LucaFabrizio GardoniElsevierarticleAMPA receptorsSynaptic plasticitySynaptic transmissionAutoimmunityNeurodegenerationGlutamateNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeurobiology of Disease, Vol 161, Iss , Pp 105539- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	AMPA receptors Synaptic plasticity Synaptic transmission Autoimmunity Neurodegeneration Glutamate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	AMPA receptors Synaptic plasticity Synaptic transmission Autoimmunity Neurodegeneration Glutamate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Maria Italia Elena Ferrari Monica Di Luca Fabrizio Gardoni GluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders
description	In the mammalian brain, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) play a fundamental role in the activation of excitatory synaptic transmission and the induction of different forms of synaptic plasticity. The modulation of the AMPAR tetramer subunit composition at synapses defines the functional properties of the receptor. During the last twenty years, several studies have evaluated the roles played by each subunit, from GluA1 to GluA4, in both physiological and pathological conditions. Here, we have focused our attention on GluA3-containing AMPARs, addressing their functional role in synaptic transmission and synaptic plasticity and their involvement in a variety of brain disorders.Although several aspects remain to be fully understood, GluA3 is a widely expressed and functionally relevant subunit in AMPARs involved in several brain circuits, and its pharmacological modulation could represent a novel approach for the rescue of altered glutamatergic synapses associated with neurodegenerative and neurodevelopmental disorders.
format	article
author	Maria Italia Elena Ferrari Monica Di Luca Fabrizio Gardoni
author_facet	Maria Italia Elena Ferrari Monica Di Luca Fabrizio Gardoni
author_sort	Maria Italia
title	GluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders
title_short	GluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders
title_full	GluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders
title_fullStr	GluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders
title_full_unstemmed	GluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders
title_sort	glua3-containing ampa receptors: from physiology to synaptic dysfunction in brain disorders
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/0270aa965eae488389c05376df29e190
work_keys_str_mv	AT mariaitalia glua3containingampareceptorsfromphysiologytosynapticdysfunctioninbraindisorders AT elenaferrari glua3containingampareceptorsfromphysiologytosynapticdysfunctioninbraindisorders AT monicadiluca glua3containingampareceptorsfromphysiologytosynapticdysfunctioninbraindisorders AT fabriziogardoni glua3containingampareceptorsfromphysiologytosynapticdysfunctioninbraindisorders
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GluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders

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