Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria

Eller et al. develop a Facile Accelerated Specific Therapeutic (FAST) platform of antisense therapeutics that targets MDR bacterial pathogens with peptide nucleic acids (PNAs). This platform designs species and/or sequence specific PNAS based on a bioinformatics toolbox and offers a new delivery app...

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Autores principales:	Kristen A. Eller, Thomas R. Aunins, Colleen M. Courtney, Jocelyn K. Campos, Peter B. Otoupal, Keesha E. Erickson, Nancy E. Madinger, Anushree Chatterjee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0271799d70ee4c3f8b4bf205f57be3d9
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spelling	oai:doaj.org-article:0271799d70ee4c3f8b4bf205f57be3d92021-12-02T11:36:25ZFacile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria10.1038/s42003-021-01856-12399-3642https://doaj.org/article/0271799d70ee4c3f8b4bf205f57be3d92021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01856-1https://doaj.org/toc/2399-3642Eller et al. develop a Facile Accelerated Specific Therapeutic (FAST) platform of antisense therapeutics that targets MDR bacterial pathogens with peptide nucleic acids (PNAs). This platform designs species and/or sequence specific PNAS based on a bioinformatics toolbox and offers a new delivery approach by repurposing the bacterial Type III secretion system in conjunction with a kill switch to overcome limited transport of PNAs into mammalian cells.Kristen A. EllerThomas R. AuninsColleen M. CourtneyJocelyn K. CamposPeter B. OtoupalKeesha E. EricksonNancy E. MadingerAnushree ChatterjeeNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Kristen A. Eller Thomas R. Aunins Colleen M. Courtney Jocelyn K. Campos Peter B. Otoupal Keesha E. Erickson Nancy E. Madinger Anushree Chatterjee Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria
description	Eller et al. develop a Facile Accelerated Specific Therapeutic (FAST) platform of antisense therapeutics that targets MDR bacterial pathogens with peptide nucleic acids (PNAs). This platform designs species and/or sequence specific PNAS based on a bioinformatics toolbox and offers a new delivery approach by repurposing the bacterial Type III secretion system in conjunction with a kill switch to overcome limited transport of PNAs into mammalian cells.
format	article
author	Kristen A. Eller Thomas R. Aunins Colleen M. Courtney Jocelyn K. Campos Peter B. Otoupal Keesha E. Erickson Nancy E. Madinger Anushree Chatterjee
author_facet	Kristen A. Eller Thomas R. Aunins Colleen M. Courtney Jocelyn K. Campos Peter B. Otoupal Keesha E. Erickson Nancy E. Madinger Anushree Chatterjee
author_sort	Kristen A. Eller
title	Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria
title_short	Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria
title_full	Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria
title_fullStr	Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria
title_full_unstemmed	Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria
title_sort	facile accelerated specific therapeutic (fast) platform develops antisense therapies to counter multidrug-resistant bacteria
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0271799d70ee4c3f8b4bf205f57be3d9
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Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria

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