Cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles

Abstract Referrals for gender dysphoria (GD), characterized by a distressful incongruence between gender identity and at-birth assigned sex, are steadily increasing. The underlying neurobiology, and the mechanisms of the often-beneficial cross-sex hormone treatment are unknown. Here, we test hypothe...

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Autores principales:	Behzad S. Khorashad, Amirhossein Manzouri, Jamie D. Feusner, Ivanka Savic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0278cd57cab64e74b3a521a268695729
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spelling	oai:doaj.org-article:0278cd57cab64e74b3a521a2686957292021-12-02T10:44:08ZCross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles10.1038/s41598-020-80687-22045-2322https://doaj.org/article/0278cd57cab64e74b3a521a2686957292021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80687-2https://doaj.org/toc/2045-2322Abstract Referrals for gender dysphoria (GD), characterized by a distressful incongruence between gender identity and at-birth assigned sex, are steadily increasing. The underlying neurobiology, and the mechanisms of the often-beneficial cross-sex hormone treatment are unknown. Here, we test hypothesis that own body perception networks (incorporated in the default mode network—DMN, and partly in the salience network—SN), are different in trans-compared with cis-gender persons. We also investigate whether these networks change with cross-sex hormone treatment. Forty transmen (TrM) and 25 transwomen (TrW) were scanned before and after cross-sex hormone institution. We used our own developed Body Morph test (BM), to assess the perception of own body as self. Fifteen cisgender persons were controls. Within and between-group differences in functional connectivity were calculated using independent components analysis within the DMN, SN, and motor network (a control network). Pretreatment, TrM and TrW scored lower “self” on the BM test than controls. Their functional connections were weaker in the anterior cingulate-, mesial prefrontal-cortex (mPFC), precuneus, the left angular gyrus, and superior parietal cortex of the DMN, and ACC in the SN “Self” identification and connectivity in the mPFC in both TrM and TrW increased from scan 1 to 2, and at scan 2 no group differences remained. The neurobiological underpinnings of GD seem subserved by cerebral structures composing major parts of the DMN.Behzad S. KhorashadAmirhossein ManzouriJamie D. FeusnerIvanka SavicNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Behzad S. Khorashad Amirhossein Manzouri Jamie D. Feusner Ivanka Savic Cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles
description	Abstract Referrals for gender dysphoria (GD), characterized by a distressful incongruence between gender identity and at-birth assigned sex, are steadily increasing. The underlying neurobiology, and the mechanisms of the often-beneficial cross-sex hormone treatment are unknown. Here, we test hypothesis that own body perception networks (incorporated in the default mode network—DMN, and partly in the salience network—SN), are different in trans-compared with cis-gender persons. We also investigate whether these networks change with cross-sex hormone treatment. Forty transmen (TrM) and 25 transwomen (TrW) were scanned before and after cross-sex hormone institution. We used our own developed Body Morph test (BM), to assess the perception of own body as self. Fifteen cisgender persons were controls. Within and between-group differences in functional connectivity were calculated using independent components analysis within the DMN, SN, and motor network (a control network). Pretreatment, TrM and TrW scored lower “self” on the BM test than controls. Their functional connections were weaker in the anterior cingulate-, mesial prefrontal-cortex (mPFC), precuneus, the left angular gyrus, and superior parietal cortex of the DMN, and ACC in the SN “Self” identification and connectivity in the mPFC in both TrM and TrW increased from scan 1 to 2, and at scan 2 no group differences remained. The neurobiological underpinnings of GD seem subserved by cerebral structures composing major parts of the DMN.
format	article
author	Behzad S. Khorashad Amirhossein Manzouri Jamie D. Feusner Ivanka Savic
author_facet	Behzad S. Khorashad Amirhossein Manzouri Jamie D. Feusner Ivanka Savic
author_sort	Behzad S. Khorashad
title	Cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles
title_short	Cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles
title_full	Cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles
title_fullStr	Cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles
title_full_unstemmed	Cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles
title_sort	cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0278cd57cab64e74b3a521a268695729
work_keys_str_mv	AT behzadskhorashad crosssexhormonetreatmentandownbodyperceptionbehavioralandbrainconnectivityprofiles AT amirhosseinmanzouri crosssexhormonetreatmentandownbodyperceptionbehavioralandbrainconnectivityprofiles AT jamiedfeusner crosssexhormonetreatmentandownbodyperceptionbehavioralandbrainconnectivityprofiles AT ivankasavic crosssexhormonetreatmentandownbodyperceptionbehavioralandbrainconnectivityprofiles
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Cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles

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