Are child and adolescent responses to placebo higher in major depression than in anxiety disorders? A systematic review of placebo-controlled trials.

<h4>Background</h4>In a previous report, we hypothesized that responses to placebo were high in child and adolescent depression because of specific psychopathological factors associated with youth major depression. The purpose of this study was to compare the placebo response rates in ph...

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Autores principales:	David Cohen, Emmanuelle Deniau, Alejandro Maturana, Marie-Laure Tanguy, Nicolas Bodeau, Réal Labelle, Jean-Jacques Breton, Jean-Marc Guile
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0279ccf519424712bd2d503f1de68a2b
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spelling	oai:doaj.org-article:0279ccf519424712bd2d503f1de68a2b2021-11-25T06:11:40ZAre child and adolescent responses to placebo higher in major depression than in anxiety disorders? A systematic review of placebo-controlled trials.1932-620310.1371/journal.pone.0002632https://doaj.org/article/0279ccf519424712bd2d503f1de68a2b2008-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18612460/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>In a previous report, we hypothesized that responses to placebo were high in child and adolescent depression because of specific psychopathological factors associated with youth major depression. The purpose of this study was to compare the placebo response rates in pharmacological trials for major depressive disorder (MDD), obsessive compulsive disorder (OCD) and other anxiety disorders (AD-non-OCD).<h4>Methodology and principal findings</h4>We reviewed the literature relevant to the use of psychotropic medication in children and adolescents with internalized disorders, restricting our review to double-blind studies including a placebo arm. Placebo response rates were pooled and compared according to diagnosis (MDD vs. OCD vs. AD-non-OCD), age (adolescent vs. child), and date of publication. From 1972 to 2007, we found 23 trials that evaluated the efficacy of psychotropic medication (mainly non-tricyclic antidepressants) involving youth with MDD, 7 pertaining to youth with OCD, and 10 pertaining to youth with other anxiety disorders (N = 2533 patients in placebo arms). As hypothesized, the placebo response rate was significantly higher in studies on MDD, than in those examining OCD and AD-non-OCD (49.6% [range: 17-90%] vs. 31% [range: 4-41%] vs. 39.6% [range: 9-53], respectively, ANOVA F = 7.1, p = 0.002). Children showed a higher stable placebo response within all three diagnoses than adolescents, though this difference was not significant. Finally, no significant effects were found with respect to the year of publication.<h4>Conclusion</h4>MDD in children and adolescents appears to be more responsive to placebo than other internalized conditions, which highlights differential psychopathology.David CohenEmmanuelle DeniauAlejandro MaturanaMarie-Laure TanguyNicolas BodeauRéal LabelleJean-Jacques BretonJean-Marc GuilePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 7, p e2632 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David Cohen Emmanuelle Deniau Alejandro Maturana Marie-Laure Tanguy Nicolas Bodeau Réal Labelle Jean-Jacques Breton Jean-Marc Guile Are child and adolescent responses to placebo higher in major depression than in anxiety disorders? A systematic review of placebo-controlled trials.
description	<h4>Background</h4>In a previous report, we hypothesized that responses to placebo were high in child and adolescent depression because of specific psychopathological factors associated with youth major depression. The purpose of this study was to compare the placebo response rates in pharmacological trials for major depressive disorder (MDD), obsessive compulsive disorder (OCD) and other anxiety disorders (AD-non-OCD).<h4>Methodology and principal findings</h4>We reviewed the literature relevant to the use of psychotropic medication in children and adolescents with internalized disorders, restricting our review to double-blind studies including a placebo arm. Placebo response rates were pooled and compared according to diagnosis (MDD vs. OCD vs. AD-non-OCD), age (adolescent vs. child), and date of publication. From 1972 to 2007, we found 23 trials that evaluated the efficacy of psychotropic medication (mainly non-tricyclic antidepressants) involving youth with MDD, 7 pertaining to youth with OCD, and 10 pertaining to youth with other anxiety disorders (N = 2533 patients in placebo arms). As hypothesized, the placebo response rate was significantly higher in studies on MDD, than in those examining OCD and AD-non-OCD (49.6% [range: 17-90%] vs. 31% [range: 4-41%] vs. 39.6% [range: 9-53], respectively, ANOVA F = 7.1, p = 0.002). Children showed a higher stable placebo response within all three diagnoses than adolescents, though this difference was not significant. Finally, no significant effects were found with respect to the year of publication.<h4>Conclusion</h4>MDD in children and adolescents appears to be more responsive to placebo than other internalized conditions, which highlights differential psychopathology.
format	article
author	David Cohen Emmanuelle Deniau Alejandro Maturana Marie-Laure Tanguy Nicolas Bodeau Réal Labelle Jean-Jacques Breton Jean-Marc Guile
author_facet	David Cohen Emmanuelle Deniau Alejandro Maturana Marie-Laure Tanguy Nicolas Bodeau Réal Labelle Jean-Jacques Breton Jean-Marc Guile
author_sort	David Cohen
title	Are child and adolescent responses to placebo higher in major depression than in anxiety disorders? A systematic review of placebo-controlled trials.
title_short	Are child and adolescent responses to placebo higher in major depression than in anxiety disorders? A systematic review of placebo-controlled trials.
title_full	Are child and adolescent responses to placebo higher in major depression than in anxiety disorders? A systematic review of placebo-controlled trials.
title_fullStr	Are child and adolescent responses to placebo higher in major depression than in anxiety disorders? A systematic review of placebo-controlled trials.
title_full_unstemmed	Are child and adolescent responses to placebo higher in major depression than in anxiety disorders? A systematic review of placebo-controlled trials.
title_sort	are child and adolescent responses to placebo higher in major depression than in anxiety disorders? a systematic review of placebo-controlled trials.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/0279ccf519424712bd2d503f1de68a2b
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Are child and adolescent responses to placebo higher in major depression than in anxiety disorders? A systematic review of placebo-controlled trials.

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