TOLL-LIKE RECEPTOR 7 GENE Gln11Leu MISSENSEMUTATION AND SUSCEPTIBILITY TO PSORIASIS

Toll-like receptor (TLR) are responsible for recognizing various molecular patterns associated with pathogens. Their expression have been detected in skin cells such as keratinocytes and melanocytes. Numerous experimental studies demonstrate the key role of TLRs in the pathogenesis of immune disease...

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Autores principales:	E. S. Galimova, K. Kingo, S. Koks
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	psoriasis innate immunity genetics tlr7 gene missense-mutation gln11leu association Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/027ac2e490d54a099f2c0fbb71dbdb87
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spelling	oai:doaj.org-article:027ac2e490d54a099f2c0fbb71dbdb872021-11-18T08:03:46ZTOLL-LIKE RECEPTOR 7 GENE Gln11Leu MISSENSEMUTATION AND SUSCEPTIBILITY TO PSORIASIS1563-06252313-741X10.15789/1563-0625-2017-3-267-274https://doaj.org/article/027ac2e490d54a099f2c0fbb71dbdb872017-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1260https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XToll-like receptor (TLR) are responsible for recognizing various molecular patterns associated with pathogens. Their expression have been detected in skin cells such as keratinocytes and melanocytes. Numerous experimental studies demonstrate the key role of TLRs in the pathogenesis of immune diseases, including psoriasis. The objective of this study is to analyze the associations of polymorphisms in TLR7 gene and the risk of psoriasis development. DNA samples were collected from 138 patients with psoriasis and 317 healthy controls. Genotyping of rs179003, rs179008, rs179020, rs850632, rs12013728 polymorphic loci in TLR7 gene was performed using the SNPlex™method (AB, USA). SNP in the TLR7 gene rs179008 (Gln11Leu) was associated with psoriasis in entire psoriasis, late onset and sporadic subgroups (Рс = 0.0065, OR = 1.95; Рс = 0.0004, OR = 2.50; Рс = 0.0078, OR = 2.2, respectively). In conclusion, this study is the first to identify genetic variants of the TLR7 gene significantly associated with psoriasis.E. S. GalimovaK. KingoS. KoksSPb RAACIarticlepsoriasisinnate immunitygeneticstlr7 genemissense-mutation gln11leuassociationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 3, Pp 267-274 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	psoriasis innate immunity genetics tlr7 gene missense-mutation gln11leu association Immunologic diseases. Allergy RC581-607
spellingShingle	psoriasis innate immunity genetics tlr7 gene missense-mutation gln11leu association Immunologic diseases. Allergy RC581-607 E. S. Galimova K. Kingo S. Koks TOLL-LIKE RECEPTOR 7 GENE Gln11Leu MISSENSEMUTATION AND SUSCEPTIBILITY TO PSORIASIS
description	Toll-like receptor (TLR) are responsible for recognizing various molecular patterns associated with pathogens. Their expression have been detected in skin cells such as keratinocytes and melanocytes. Numerous experimental studies demonstrate the key role of TLRs in the pathogenesis of immune diseases, including psoriasis. The objective of this study is to analyze the associations of polymorphisms in TLR7 gene and the risk of psoriasis development. DNA samples were collected from 138 patients with psoriasis and 317 healthy controls. Genotyping of rs179003, rs179008, rs179020, rs850632, rs12013728 polymorphic loci in TLR7 gene was performed using the SNPlex™method (AB, USA). SNP in the TLR7 gene rs179008 (Gln11Leu) was associated with psoriasis in entire psoriasis, late onset and sporadic subgroups (Рс = 0.0065, OR = 1.95; Рс = 0.0004, OR = 2.50; Рс = 0.0078, OR = 2.2, respectively). In conclusion, this study is the first to identify genetic variants of the TLR7 gene significantly associated with psoriasis.
format	article
author	E. S. Galimova K. Kingo S. Koks
author_facet	E. S. Galimova K. Kingo S. Koks
author_sort	E. S. Galimova
title	TOLL-LIKE RECEPTOR 7 GENE Gln11Leu MISSENSEMUTATION AND SUSCEPTIBILITY TO PSORIASIS
title_short	TOLL-LIKE RECEPTOR 7 GENE Gln11Leu MISSENSEMUTATION AND SUSCEPTIBILITY TO PSORIASIS
title_full	TOLL-LIKE RECEPTOR 7 GENE Gln11Leu MISSENSEMUTATION AND SUSCEPTIBILITY TO PSORIASIS
title_fullStr	TOLL-LIKE RECEPTOR 7 GENE Gln11Leu MISSENSEMUTATION AND SUSCEPTIBILITY TO PSORIASIS
title_full_unstemmed	TOLL-LIKE RECEPTOR 7 GENE Gln11Leu MISSENSEMUTATION AND SUSCEPTIBILITY TO PSORIASIS
title_sort	toll-like receptor 7 gene gln11leu missensemutation and susceptibility to psoriasis
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/027ac2e490d54a099f2c0fbb71dbdb87
work_keys_str_mv	AT esgalimova tolllikereceptor7genegln11leumissensemutationandsusceptibilitytopsoriasis AT kkingo tolllikereceptor7genegln11leumissensemutationandsusceptibilitytopsoriasis AT skoks tolllikereceptor7genegln11leumissensemutationandsusceptibilitytopsoriasis
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TOLL-LIKE RECEPTOR 7 GENE Gln11Leu MISSENSEMUTATION AND SUSCEPTIBILITY TO PSORIASIS

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