The role of vitamin D in subjective tinnitus-A case-control study.

Regarding the high prevalence of vitamin D (25(OH)D) deficiency in the population and its possible association with ear diseases, we aimed to investigate the 25(OH)Dserum level in patients with subjective, nonpulsating tinnitus and its effect on tinnitus severity. The study included 201 tinnitus pat...

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Autores principales:	Magdalena Nowaczewska, Stanisław Osiński, Maria Marzec, Michał Wiciński, Katarzyna Bilicka, Wojciech Kaźmierczak
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0281da6e11e34620899cf55c40ba2567
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spelling	oai:doaj.org-article:0281da6e11e34620899cf55c40ba25672021-12-02T20:17:52ZThe role of vitamin D in subjective tinnitus-A case-control study.1932-620310.1371/journal.pone.0255482https://doaj.org/article/0281da6e11e34620899cf55c40ba25672021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255482https://doaj.org/toc/1932-6203Regarding the high prevalence of vitamin D (25(OH)D) deficiency in the population and its possible association with ear diseases, we aimed to investigate the 25(OH)Dserum level in patients with subjective, nonpulsating tinnitus and its effect on tinnitus severity. The study included 201 tinnitus patients and 99 controls. Patient clinical information, including tinnitus characteristics and severity according to Tinnitus Handicap Inventory (THI), loudness assessed by Visual Analogue Scale (VAS), audiometry, and the blood level of vitamin D, was recorded. The level of 25(OH)D in tinnitus patients was significantly decreased compared with the controls (19.86 ± 7.53 and 27.43 ± 8.85 ng/ml, respectively; P value < 0.0001). More patients in the tinnitus group were deficient in vitamin D, compared with the controls (50.7% vs. 22.2% respectively, p < 0.0001). Tinnitus patients with a lower serum level of 25(OH)D (≤15 ng/dl) were significantly younger, had a higher degree of tinnitus severity measured with THI and VAS scales, had higher triglyceride and TSH levels, and a lower HDL level compared with individuals who had higher 25(OH)D level (>15 ng/dl). There was a strong correlation between the 25(OH)D level and THI. Our findings suggest that a large proportion of tinnitus patients suffers from vitamin D deficiency and that the vitamin D level correlates with tinnitus impact. We recommend a vitamin D assessment for all tinnitus patients.Magdalena NowaczewskaStanisław OsińskiMaria MarzecMichał WicińskiKatarzyna BilickaWojciech KaźmierczakPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255482 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Magdalena Nowaczewska Stanisław Osiński Maria Marzec Michał Wiciński Katarzyna Bilicka Wojciech Kaźmierczak The role of vitamin D in subjective tinnitus-A case-control study.
description	Regarding the high prevalence of vitamin D (25(OH)D) deficiency in the population and its possible association with ear diseases, we aimed to investigate the 25(OH)Dserum level in patients with subjective, nonpulsating tinnitus and its effect on tinnitus severity. The study included 201 tinnitus patients and 99 controls. Patient clinical information, including tinnitus characteristics and severity according to Tinnitus Handicap Inventory (THI), loudness assessed by Visual Analogue Scale (VAS), audiometry, and the blood level of vitamin D, was recorded. The level of 25(OH)D in tinnitus patients was significantly decreased compared with the controls (19.86 ± 7.53 and 27.43 ± 8.85 ng/ml, respectively; P value < 0.0001). More patients in the tinnitus group were deficient in vitamin D, compared with the controls (50.7% vs. 22.2% respectively, p < 0.0001). Tinnitus patients with a lower serum level of 25(OH)D (≤15 ng/dl) were significantly younger, had a higher degree of tinnitus severity measured with THI and VAS scales, had higher triglyceride and TSH levels, and a lower HDL level compared with individuals who had higher 25(OH)D level (>15 ng/dl). There was a strong correlation between the 25(OH)D level and THI. Our findings suggest that a large proportion of tinnitus patients suffers from vitamin D deficiency and that the vitamin D level correlates with tinnitus impact. We recommend a vitamin D assessment for all tinnitus patients.
format	article
author	Magdalena Nowaczewska Stanisław Osiński Maria Marzec Michał Wiciński Katarzyna Bilicka Wojciech Kaźmierczak
author_facet	Magdalena Nowaczewska Stanisław Osiński Maria Marzec Michał Wiciński Katarzyna Bilicka Wojciech Kaźmierczak
author_sort	Magdalena Nowaczewska
title	The role of vitamin D in subjective tinnitus-A case-control study.
title_short	The role of vitamin D in subjective tinnitus-A case-control study.
title_full	The role of vitamin D in subjective tinnitus-A case-control study.
title_fullStr	The role of vitamin D in subjective tinnitus-A case-control study.
title_full_unstemmed	The role of vitamin D in subjective tinnitus-A case-control study.
title_sort	role of vitamin d in subjective tinnitus-a case-control study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0281da6e11e34620899cf55c40ba2567
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The role of vitamin D in subjective tinnitus-A case-control study.

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