Measuring macromolecular size distributions and interactions at high concentrations by sedimentation velocity

Many aspects of concentrated macromolecular solutions, such as encountered in cytosol or in pharmaceutical formulations, are dependent on particle size distributions and weak intermolecular interactions. Here, the authors exploit hydrodynamic separation in the centrifugal field to measure both.

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Bibliographic Details
Main Authors: Sumit K. Chaturvedi, Jia Ma, Patrick H. Brown, Huaying Zhao, P. Schuck
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/0284d7ffc688470fba2b7cb0ce682d70
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