Retrospective analysis of an intraoperative aberrometry database: a study investigating absolute prediction in eyes implanted with low cylinder power toric intraocular lenses

Robert J Cionni,1 Michael Breen,2 Cody Hamilton,3 Ravaughn Williams41The Eye Institute of Utah, Salt Lake City, UT, USA; 2North America Clinical Development and Medical Affairs, Alcon Laboratories, Inc., Fort Worth, TX, USA; 3Biostatistics, Alcon Laboratories, Inc., Fort Worth, TX, USA; 4Global Clin...

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Autores principales:	Cionni RJ, Breen M, Hamilton C, Williams R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Astigmatism Intraocular lenses Low toric lenses Spherical equivalent outcomes Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/02854f628633438a81d68b23f33f295a
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spelling	oai:doaj.org-article:02854f628633438a81d68b23f33f295a2021-12-02T05:18:13ZRetrospective analysis of an intraoperative aberrometry database: a study investigating absolute prediction in eyes implanted with low cylinder power toric intraocular lenses1177-5483https://doaj.org/article/02854f628633438a81d68b23f33f295a2019-08-01T00:00:00Zhttps://www.dovepress.com/retrospective-analysis-of-an-intraoperative-aberrometry-database-a-stu-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Robert J Cionni,1 Michael Breen,2 Cody Hamilton,3 Ravaughn Williams41The Eye Institute of Utah, Salt Lake City, UT, USA; 2North America Clinical Development and Medical Affairs, Alcon Laboratories, Inc., Fort Worth, TX, USA; 3Biostatistics, Alcon Laboratories, Inc., Fort Worth, TX, USA; 4Global Clinical Development and Medical Affairs, Alcon Laboratories, Fort Worth, TX, USAPurpose: To evaluate the spherical equivalent outcomes of intraoperative aberrometry (IA) power calculations compared with the surgeons’ preoperative power calculations in eyes implanted with AcrySof® IQ T3 intraocular lenses (IOLs).Patients and methods: We assessed data collected by an IA system from multiple centers in the United States. Data was from patients who had undergone cataract extraction by phacoemulsification with the use of the Optiwave Refractive Analysis System and whose eyes had been implanted with model SN6AT3 (1.5 diopter [D] at IOL plane) aspheric lenses. The analysis was performed in 2 stages: hypothesis generation and confirmatory testing. Confirmatory endpoints were a comparison of absolute prediction errors for IA for the implanted IOL versus preoperative formula power calculations.Design: Retrospective analysis of preoperative, intraoperative, and postoperative data concerning eyes implanted with model SN6AT3 (1.5 D) aspheric lenses from the AnalyzOR™ database.Results: Mean absolute IA prediction error was significantly lower than preoperative prediction error (paired difference: −0.06 D; p<0.0001); this was mirrored by the median paired difference of −0.04 D (p<0.0001). For eyes where the power of the implanted IOL differed from the power of the preoperatively planned lens, mean and median paired differences in prediction errors were greater: −0.13 D (p<0.0001) and −0.15 D (p<0.0001), respectively. The percentage of eyes with prediction error ≤0.50 D was significantly higher with IA (83.4%, n=5388/6460) than with the preoperative formula (76.5%, n=4942/6460, p<0.0001). When the powers of the implanted IOL and the preoperatively planned lens were different, the percentage of eyes with prediction error ≤0.50 D was 83.3% (2155/2587) for IA and 68.8% (1781/2587, p<0.0001) for the preoperative formula.Conclusion: IA produces more accurate spherical equivalent outcomes for eyes implanted with a low toric IOL than the preoperative formulas.Keywords: astigmatism, intraocular lenses, low toric lenses, spherical equivalent outcomes  Cionni RJBreen MHamilton CWilliams RDove Medical PressarticleAstigmatismIntraocular lensesLow toric lensesSpherical equivalent outcomesOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1485-1492 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Astigmatism Intraocular lenses Low toric lenses Spherical equivalent outcomes Ophthalmology RE1-994
spellingShingle	Astigmatism Intraocular lenses Low toric lenses Spherical equivalent outcomes Ophthalmology RE1-994 Cionni RJ Breen M Hamilton C Williams R Retrospective analysis of an intraoperative aberrometry database: a study investigating absolute prediction in eyes implanted with low cylinder power toric intraocular lenses
description	Robert J Cionni,1 Michael Breen,2 Cody Hamilton,3 Ravaughn Williams41The Eye Institute of Utah, Salt Lake City, UT, USA; 2North America Clinical Development and Medical Affairs, Alcon Laboratories, Inc., Fort Worth, TX, USA; 3Biostatistics, Alcon Laboratories, Inc., Fort Worth, TX, USA; 4Global Clinical Development and Medical Affairs, Alcon Laboratories, Fort Worth, TX, USAPurpose: To evaluate the spherical equivalent outcomes of intraoperative aberrometry (IA) power calculations compared with the surgeons’ preoperative power calculations in eyes implanted with AcrySof® IQ T3 intraocular lenses (IOLs).Patients and methods: We assessed data collected by an IA system from multiple centers in the United States. Data was from patients who had undergone cataract extraction by phacoemulsification with the use of the Optiwave Refractive Analysis System and whose eyes had been implanted with model SN6AT3 (1.5 diopter [D] at IOL plane) aspheric lenses. The analysis was performed in 2 stages: hypothesis generation and confirmatory testing. Confirmatory endpoints were a comparison of absolute prediction errors for IA for the implanted IOL versus preoperative formula power calculations.Design: Retrospective analysis of preoperative, intraoperative, and postoperative data concerning eyes implanted with model SN6AT3 (1.5 D) aspheric lenses from the AnalyzOR™ database.Results: Mean absolute IA prediction error was significantly lower than preoperative prediction error (paired difference: −0.06 D; p<0.0001); this was mirrored by the median paired difference of −0.04 D (p<0.0001). For eyes where the power of the implanted IOL differed from the power of the preoperatively planned lens, mean and median paired differences in prediction errors were greater: −0.13 D (p<0.0001) and −0.15 D (p<0.0001), respectively. The percentage of eyes with prediction error ≤0.50 D was significantly higher with IA (83.4%, n=5388/6460) than with the preoperative formula (76.5%, n=4942/6460, p<0.0001). When the powers of the implanted IOL and the preoperatively planned lens were different, the percentage of eyes with prediction error ≤0.50 D was 83.3% (2155/2587) for IA and 68.8% (1781/2587, p<0.0001) for the preoperative formula.Conclusion: IA produces more accurate spherical equivalent outcomes for eyes implanted with a low toric IOL than the preoperative formulas.Keywords: astigmatism, intraocular lenses, low toric lenses, spherical equivalent outcomes
format	article
author	Cionni RJ Breen M Hamilton C Williams R
author_facet	Cionni RJ Breen M Hamilton C Williams R
author_sort	Cionni RJ
title	Retrospective analysis of an intraoperative aberrometry database: a study investigating absolute prediction in eyes implanted with low cylinder power toric intraocular lenses
title_short	Retrospective analysis of an intraoperative aberrometry database: a study investigating absolute prediction in eyes implanted with low cylinder power toric intraocular lenses
title_full	Retrospective analysis of an intraoperative aberrometry database: a study investigating absolute prediction in eyes implanted with low cylinder power toric intraocular lenses
title_fullStr	Retrospective analysis of an intraoperative aberrometry database: a study investigating absolute prediction in eyes implanted with low cylinder power toric intraocular lenses
title_full_unstemmed	Retrospective analysis of an intraoperative aberrometry database: a study investigating absolute prediction in eyes implanted with low cylinder power toric intraocular lenses
title_sort	retrospective analysis of an intraoperative aberrometry database: a study investigating absolute prediction in eyes implanted with low cylinder power toric intraocular lenses
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/02854f628633438a81d68b23f33f295a
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Retrospective analysis of an intraoperative aberrometry database: a study investigating absolute prediction in eyes implanted with low cylinder power toric intraocular lenses

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