Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia.

Recently, two genome scan meta-analysis studies have found strong evidence for the association of loci on chromosome 8p with schizophrenia. The early growth response 3 (EGR3) gene located in chromosome 8p21.3 was also found to be involved in the etiology of schizophrenia. However, subsequent studies...

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Autores principales:	Rui Zhang, Shemin Lu, Liesu Meng, Zixin Min, Juan Tian, Robert K Valenzuela, Tingwei Guo, Lifang Tian, Wenxiang Zhao, Jie Ma
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/02855b39da6b4daca84ddca48f2ad0eb
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spelling	oai:doaj.org-article:02855b39da6b4daca84ddca48f2ad0eb2021-11-18T07:29:44ZGenetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia.1932-620310.1371/journal.pone.0030237https://doaj.org/article/02855b39da6b4daca84ddca48f2ad0eb2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22276163/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Recently, two genome scan meta-analysis studies have found strong evidence for the association of loci on chromosome 8p with schizophrenia. The early growth response 3 (EGR3) gene located in chromosome 8p21.3 was also found to be involved in the etiology of schizophrenia. However, subsequent studies failed to replicate this finding. To investigate the genetic role of EGR3 in Chinese patients, we genotyped four SNPs (average interval ∼2.3 kb) in the chromosome region of EGR3 in 470 Chinese schizophrenia patients and 480 healthy control subjects. The SNP rs35201266 (located in intron 1 of EGR3) showed significant differences between cases and controls in both genotype frequency distribution (P = 0.016) and allele frequency distribution (P = 0.009). Analysis of the haplotype rs35201266-rs3750192 provided significant evidence for association with schizophrenia (P = 0.0012); a significant difference was found for the common haplotype AG (P = 0.0005). Furthermore, significant associations were also found in several other two-, and three-SNP tests of haplotype analyses. The meta-analysis revealed a statistically significant association between rs35201266 and schizophrenia (P = 0.0001). In summary, our study supports the association of EGR3 with schizophrenia in our Han Chinese sample, and further functional exploration of the EGR3 gene will contribute to the molecular basis for the complex network underlying schizophrenia pathogenesis.Rui ZhangShemin LuShemin LuLiesu MengZixin MinJuan TianRobert K ValenzuelaTingwei GuoLifang TianWenxiang ZhaoJie MaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e30237 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rui Zhang Shemin Lu Shemin Lu Liesu Meng Zixin Min Juan Tian Robert K Valenzuela Tingwei Guo Lifang Tian Wenxiang Zhao Jie Ma Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia.
description	Recently, two genome scan meta-analysis studies have found strong evidence for the association of loci on chromosome 8p with schizophrenia. The early growth response 3 (EGR3) gene located in chromosome 8p21.3 was also found to be involved in the etiology of schizophrenia. However, subsequent studies failed to replicate this finding. To investigate the genetic role of EGR3 in Chinese patients, we genotyped four SNPs (average interval ∼2.3 kb) in the chromosome region of EGR3 in 470 Chinese schizophrenia patients and 480 healthy control subjects. The SNP rs35201266 (located in intron 1 of EGR3) showed significant differences between cases and controls in both genotype frequency distribution (P = 0.016) and allele frequency distribution (P = 0.009). Analysis of the haplotype rs35201266-rs3750192 provided significant evidence for association with schizophrenia (P = 0.0012); a significant difference was found for the common haplotype AG (P = 0.0005). Furthermore, significant associations were also found in several other two-, and three-SNP tests of haplotype analyses. The meta-analysis revealed a statistically significant association between rs35201266 and schizophrenia (P = 0.0001). In summary, our study supports the association of EGR3 with schizophrenia in our Han Chinese sample, and further functional exploration of the EGR3 gene will contribute to the molecular basis for the complex network underlying schizophrenia pathogenesis.
format	article
author	Rui Zhang Shemin Lu Shemin Lu Liesu Meng Zixin Min Juan Tian Robert K Valenzuela Tingwei Guo Lifang Tian Wenxiang Zhao Jie Ma
author_facet	Rui Zhang Shemin Lu Shemin Lu Liesu Meng Zixin Min Juan Tian Robert K Valenzuela Tingwei Guo Lifang Tian Wenxiang Zhao Jie Ma
author_sort	Rui Zhang
title	Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia.
title_short	Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia.
title_full	Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia.
title_fullStr	Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia.
title_full_unstemmed	Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia.
title_sort	genetic evidence for the association between the early growth response 3 (egr3) gene and schizophrenia.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/02855b39da6b4daca84ddca48f2ad0eb
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Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia.

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