Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs.

Rattus norvegicus (Norway rat) is the main reservoir host of pathogenic Leptospira, the causative agent of leptospirosis, in urban environments. Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet b...

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Autores principales:	Ana Amélia Nunes Santos, Priscyla Dos Santos Ribeiro, Geórgia Virgínia da França, Fábio Neves Souza, Eduardo Antônio Gonçalves Ramos, Cláudio Pereira Figueira, Mitermayer G Reis, Federico Costa, Paula Ristow
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/0286175f26984e47ba859dca2543302f
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spelling	oai:doaj.org-article:0286175f26984e47ba859dca2543302f2021-12-02T20:24:09ZLeptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs.1935-27271935-273510.1371/journal.pntd.0009736https://doaj.org/article/0286175f26984e47ba859dca2543302f2021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009736https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Rattus norvegicus (Norway rat) is the main reservoir host of pathogenic Leptospira, the causative agent of leptospirosis, in urban environments. Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet been studied in natural animal reservoirs presenting leptospiral renal carriage. Here, we described biofilm formation by pathogenic Leptospira inside the renal tubules of R. norvegicus naturally infected and captured in an urban slum endemic for leptospirosis. From the 65 rats carrying Leptospira in their kidneys, 24 (37%) presented biofilms inside the renal tubules. The intensity of leptospiral colonization in the renal tubules (OR: 1.00; 95% CI 1.05-1.1) and the type of occlusion pattern of the colonized renal tubules (OR: 3.46; 95% CI 1.20-9.98) were independently associated with the presence of Leptospira biofilm. Our data showed that Leptospira interrogans produce biofilms during renal chronic colonization in rat reservoirs, suggesting a possible role for leptospiral biofilms in the pathogenesis of leptospirosis and bacterial carriage in host reservoirs.Ana Amélia Nunes SantosPriscyla Dos Santos RibeiroGeórgia Virgínia da FrançaFábio Neves SouzaEduardo Antônio Gonçalves RamosCláudio Pereira FigueiraMitermayer G ReisFederico CostaPaula RistowPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009736 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ana Amélia Nunes Santos Priscyla Dos Santos Ribeiro Geórgia Virgínia da França Fábio Neves Souza Eduardo Antônio Gonçalves Ramos Cláudio Pereira Figueira Mitermayer G Reis Federico Costa Paula Ristow Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs.
description	Rattus norvegicus (Norway rat) is the main reservoir host of pathogenic Leptospira, the causative agent of leptospirosis, in urban environments. Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet been studied in natural animal reservoirs presenting leptospiral renal carriage. Here, we described biofilm formation by pathogenic Leptospira inside the renal tubules of R. norvegicus naturally infected and captured in an urban slum endemic for leptospirosis. From the 65 rats carrying Leptospira in their kidneys, 24 (37%) presented biofilms inside the renal tubules. The intensity of leptospiral colonization in the renal tubules (OR: 1.00; 95% CI 1.05-1.1) and the type of occlusion pattern of the colonized renal tubules (OR: 3.46; 95% CI 1.20-9.98) were independently associated with the presence of Leptospira biofilm. Our data showed that Leptospira interrogans produce biofilms during renal chronic colonization in rat reservoirs, suggesting a possible role for leptospiral biofilms in the pathogenesis of leptospirosis and bacterial carriage in host reservoirs.
format	article
author	Ana Amélia Nunes Santos Priscyla Dos Santos Ribeiro Geórgia Virgínia da França Fábio Neves Souza Eduardo Antônio Gonçalves Ramos Cláudio Pereira Figueira Mitermayer G Reis Federico Costa Paula Ristow
author_facet	Ana Amélia Nunes Santos Priscyla Dos Santos Ribeiro Geórgia Virgínia da França Fábio Neves Souza Eduardo Antônio Gonçalves Ramos Cláudio Pereira Figueira Mitermayer G Reis Federico Costa Paula Ristow
author_sort	Ana Amélia Nunes Santos
title	Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs.
title_short	Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs.
title_full	Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs.
title_fullStr	Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs.
title_full_unstemmed	Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs.
title_sort	leptospira interrogans biofilm formation in rattus norvegicus (norway rats) natural reservoirs.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0286175f26984e47ba859dca2543302f
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Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs.

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