Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds

Abstract The ability to produce constructs with a high control over the bulk geometry and internal architecture has situated 3D printing as an attractive fabrication technique for scaffolds. Various designs and inks are actively investigated to prepare scaffolds for different tissues. In this work,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Amir Seyedsalehi, Leila Daneshmandi, Mohammed Barajaa, John Riordan, Cato T. Laurencin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/02871cde1e154c15856bb84b368ad5ee
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:02871cde1e154c15856bb84b368ad5ee
record_format	dspace
spelling	oai:doaj.org-article:02871cde1e154c15856bb84b368ad5ee2021-12-02T11:57:56ZFabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds10.1038/s41598-020-78977-w2045-2322https://doaj.org/article/02871cde1e154c15856bb84b368ad5ee2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78977-whttps://doaj.org/toc/2045-2322Abstract The ability to produce constructs with a high control over the bulk geometry and internal architecture has situated 3D printing as an attractive fabrication technique for scaffolds. Various designs and inks are actively investigated to prepare scaffolds for different tissues. In this work, we prepared 3D printed composite scaffolds comprising polycaprolactone (PCL) and various amounts of reduced graphene oxide (rGO) at 0.5, 1, and 3 wt.%. We employed a two-step fabrication process to ensure an even mixture and distribution of the rGO sheets within the PCL matrix. The inks were prepared by creating composite PCL-rGO films through solvent evaporation casting that were subsequently fed into the 3D printer for extrusion. The resultant scaffolds were seamlessly integrated, and 3D printed with high fidelity and consistency across all groups. This, together with the homogeneous dispersion of the rGO sheets within the polymer matrix, significantly improved the compressive strength and stiffness by 185% and 150%, respectively, at 0.5 wt.% rGO inclusion. The in vitro response of the scaffolds was assessed using human adipose-derived stem cells. All scaffolds were cytocompatible and supported cell growth and viability. These mechanically reinforced and biologically compatible 3D printed PCL-rGO scaffolds are a promising platform for regenerative engineering applications.Amir SeyedsalehiLeila DaneshmandiMohammed BarajaaJohn RiordanCato T. LaurencinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amir Seyedsalehi Leila Daneshmandi Mohammed Barajaa John Riordan Cato T. Laurencin Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds
description	Abstract The ability to produce constructs with a high control over the bulk geometry and internal architecture has situated 3D printing as an attractive fabrication technique for scaffolds. Various designs and inks are actively investigated to prepare scaffolds for different tissues. In this work, we prepared 3D printed composite scaffolds comprising polycaprolactone (PCL) and various amounts of reduced graphene oxide (rGO) at 0.5, 1, and 3 wt.%. We employed a two-step fabrication process to ensure an even mixture and distribution of the rGO sheets within the PCL matrix. The inks were prepared by creating composite PCL-rGO films through solvent evaporation casting that were subsequently fed into the 3D printer for extrusion. The resultant scaffolds were seamlessly integrated, and 3D printed with high fidelity and consistency across all groups. This, together with the homogeneous dispersion of the rGO sheets within the polymer matrix, significantly improved the compressive strength and stiffness by 185% and 150%, respectively, at 0.5 wt.% rGO inclusion. The in vitro response of the scaffolds was assessed using human adipose-derived stem cells. All scaffolds were cytocompatible and supported cell growth and viability. These mechanically reinforced and biologically compatible 3D printed PCL-rGO scaffolds are a promising platform for regenerative engineering applications.
format	article
author	Amir Seyedsalehi Leila Daneshmandi Mohammed Barajaa John Riordan Cato T. Laurencin
author_facet	Amir Seyedsalehi Leila Daneshmandi Mohammed Barajaa John Riordan Cato T. Laurencin
author_sort	Amir Seyedsalehi
title	Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds
title_short	Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds
title_full	Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds
title_fullStr	Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds
title_full_unstemmed	Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds
title_sort	fabrication and characterization of mechanically competent 3d printed polycaprolactone-reduced graphene oxide scaffolds
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/02871cde1e154c15856bb84b368ad5ee
work_keys_str_mv	AT amirseyedsalehi fabricationandcharacterizationofmechanicallycompetent3dprintedpolycaprolactonereducedgrapheneoxidescaffolds AT leiladaneshmandi fabricationandcharacterizationofmechanicallycompetent3dprintedpolycaprolactonereducedgrapheneoxidescaffolds AT mohammedbarajaa fabricationandcharacterizationofmechanicallycompetent3dprintedpolycaprolactonereducedgrapheneoxidescaffolds AT johnriordan fabricationandcharacterizationofmechanicallycompetent3dprintedpolycaprolactonereducedgrapheneoxidescaffolds AT catotlaurencin fabricationandcharacterizationofmechanicallycompetent3dprintedpolycaprolactonereducedgrapheneoxidescaffolds
_version_	1718394787917201408

Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds

Ejemplares similares