The Ino80 complex mediates epigenetic centromere propagation via active removal of histone H3

The histone variant CENP-A marks active centromeres and replaces H3 at centromeres through a poorly understood mechanism. Here, the authors provide evidence that the chromatin remodeller Ino80 promotes CENP-A chromatin assembly at the centromere in fission yeast.

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Detalles Bibliográficos
Autores principales: Eun Shik Choi, Youngseo Cheon, Keunsoo Kang, Daeyoup Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/02879fff3bb244c6a914ef2df82b912c
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Sumario:The histone variant CENP-A marks active centromeres and replaces H3 at centromeres through a poorly understood mechanism. Here, the authors provide evidence that the chromatin remodeller Ino80 promotes CENP-A chromatin assembly at the centromere in fission yeast.