Inter- and Intraobserver Repeatability of Myocardial Flow Reserve Values Determined with SPECT Study Using a Discovery NM530c Camera and Corridor 4DM Software

Background: Myocardial blood flow (MBF) and flow reserve (MFR) examination, especially useful in the diagnosis of multivessel coronary artery disease (CAD), can be assessed with a cadmium-zinc-telluride (CZT) SPECT gamma camera, as an alternative to the expensive and less available PET. However, stu...

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Autores principales:	Paweł Cichocki, Michał Błaszczyk, Kamila Cygulska, Krzysztof Filipczak, Zbigniew Adamczewski, Jacek Kuśmierek, Piotr Lipiec, Jarosław Damian Kasprzak, Anna Płachcińska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	coronary artery disease discovery NM530c myocardial flow reserve myocardial perfusion imaging technetium Tc 99m sestamibi Medicine R
Acceso en línea:	https://doaj.org/article/02888f13808e41648ccb3afcc54bbae3
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spelling	oai:doaj.org-article:02888f13808e41648ccb3afcc54bbae32021-11-25T18:07:40ZInter- and Intraobserver Repeatability of Myocardial Flow Reserve Values Determined with SPECT Study Using a Discovery NM530c Camera and Corridor 4DM Software10.3390/jpm111111642075-4426https://doaj.org/article/02888f13808e41648ccb3afcc54bbae32021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1164https://doaj.org/toc/2075-4426Background: Myocardial blood flow (MBF) and flow reserve (MFR) examination, especially useful in the diagnosis of multivessel coronary artery disease (CAD), can be assessed with a cadmium-zinc-telluride (CZT) SPECT gamma camera, as an alternative to the expensive and less available PET. However, study processing is not free from subjective factors. Therefore, this paper aims to evaluate intra- and interobserver repeatability of MBF and MFR values obtained by the same operator and two independent operators. Methods: This study included 57 adult patients. MBF and MFR were assessed using a Discovery NM530c camera in a two-day, rest/dipyridamople protocol, using <sup>99m</sup>Tc-MIBI. Data were processed using Corridor4DM software, twice by one operator and once by another operator. Results: The repeatability of the assessed values was quite good in the whole myocardium, LAD and LCX vascular territories, but was poor in the RCA territory. Conclusions: The poor repeatability of MBF and MFR in RCA vascular territory can be explained by poor automatic orientation of the heart axis during post-processing and a so-called “cardiac creep” phenomenon. Better automatic heart orientation and introduction of automatic motion correction is likely to drastically improve this repeatability. In the present state of the software, PET is better for patients requiring assessment of MFR in the RCA territory.Paweł CichockiMichał BłaszczykKamila CygulskaKrzysztof FilipczakZbigniew AdamczewskiJacek KuśmierekPiotr LipiecJarosław Damian KasprzakAnna PłachcińskaMDPI AGarticlecoronary artery diseasediscovery NM530cmyocardial flow reservemyocardial perfusion imagingtechnetium Tc 99m sestamibiMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1164, p 1164 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coronary artery disease discovery NM530c myocardial flow reserve myocardial perfusion imaging technetium Tc 99m sestamibi Medicine R
spellingShingle	coronary artery disease discovery NM530c myocardial flow reserve myocardial perfusion imaging technetium Tc 99m sestamibi Medicine R Paweł Cichocki Michał Błaszczyk Kamila Cygulska Krzysztof Filipczak Zbigniew Adamczewski Jacek Kuśmierek Piotr Lipiec Jarosław Damian Kasprzak Anna Płachcińska Inter- and Intraobserver Repeatability of Myocardial Flow Reserve Values Determined with SPECT Study Using a Discovery NM530c Camera and Corridor 4DM Software
description	Background: Myocardial blood flow (MBF) and flow reserve (MFR) examination, especially useful in the diagnosis of multivessel coronary artery disease (CAD), can be assessed with a cadmium-zinc-telluride (CZT) SPECT gamma camera, as an alternative to the expensive and less available PET. However, study processing is not free from subjective factors. Therefore, this paper aims to evaluate intra- and interobserver repeatability of MBF and MFR values obtained by the same operator and two independent operators. Methods: This study included 57 adult patients. MBF and MFR were assessed using a Discovery NM530c camera in a two-day, rest/dipyridamople protocol, using <sup>99m</sup>Tc-MIBI. Data were processed using Corridor4DM software, twice by one operator and once by another operator. Results: The repeatability of the assessed values was quite good in the whole myocardium, LAD and LCX vascular territories, but was poor in the RCA territory. Conclusions: The poor repeatability of MBF and MFR in RCA vascular territory can be explained by poor automatic orientation of the heart axis during post-processing and a so-called “cardiac creep” phenomenon. Better automatic heart orientation and introduction of automatic motion correction is likely to drastically improve this repeatability. In the present state of the software, PET is better for patients requiring assessment of MFR in the RCA territory.
format	article
author	Paweł Cichocki Michał Błaszczyk Kamila Cygulska Krzysztof Filipczak Zbigniew Adamczewski Jacek Kuśmierek Piotr Lipiec Jarosław Damian Kasprzak Anna Płachcińska
author_facet	Paweł Cichocki Michał Błaszczyk Kamila Cygulska Krzysztof Filipczak Zbigniew Adamczewski Jacek Kuśmierek Piotr Lipiec Jarosław Damian Kasprzak Anna Płachcińska
author_sort	Paweł Cichocki
title	Inter- and Intraobserver Repeatability of Myocardial Flow Reserve Values Determined with SPECT Study Using a Discovery NM530c Camera and Corridor 4DM Software
title_short	Inter- and Intraobserver Repeatability of Myocardial Flow Reserve Values Determined with SPECT Study Using a Discovery NM530c Camera and Corridor 4DM Software
title_full	Inter- and Intraobserver Repeatability of Myocardial Flow Reserve Values Determined with SPECT Study Using a Discovery NM530c Camera and Corridor 4DM Software
title_fullStr	Inter- and Intraobserver Repeatability of Myocardial Flow Reserve Values Determined with SPECT Study Using a Discovery NM530c Camera and Corridor 4DM Software
title_full_unstemmed	Inter- and Intraobserver Repeatability of Myocardial Flow Reserve Values Determined with SPECT Study Using a Discovery NM530c Camera and Corridor 4DM Software
title_sort	inter- and intraobserver repeatability of myocardial flow reserve values determined with spect study using a discovery nm530c camera and corridor 4dm software
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/02888f13808e41648ccb3afcc54bbae3
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Inter- and Intraobserver Repeatability of Myocardial Flow Reserve Values Determined with SPECT Study Using a Discovery NM530c Camera and Corridor 4DM Software

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