Adenosine/TGFβ axis in regulation of mammary fibroblast functions.

Adenosine/TGFβ axis in regulation of mammary fibroblast functions.

Cancer associated fibroblasts (CAF) play a key role in cancer progression and metastasis. Diminished TGFβ response on CAF correlates with poor outcome and recurrence in cancer patients. Mechanisms behind lost TGFβ signaling on CAF are poorly understood, but, utilizing MMTV-PyMT mouse model, we have...

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Autores principales: Georgii Vasiukov, Anna Menshikh, Philip Owens, Tatiana Novitskaya, Paula Hurley, Timothy Blackwell, Igor Feoktistov, Sergey V Novitskiy
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/0288b858ed28440ca1eea1f6336daf90
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