Inhibitor binding mode and allosteric regulation of Na + -glucose symporters

Sodium-dependent glucose transporters (SGLTs) transport sugars across the plasma membrane and play important roles in renal sugar reabsorption. Here authors develop structural models of human SGLT1/2 (hSGLT1/2) in complex with inhibitors which helps to understand inhibitor subtype selectivity.

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Autores principales:	Paola Bisignano, Chiara Ghezzi, Hyunil Jo, Nicholas F. Polizzi, Thorsten Althoff, Chakrapani Kalyanaraman, Rosmarie Friemann, Matthew P. Jacobson, Ernest M. Wright, Michael Grabe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/028c1db90c9e4f9fab9c0de09fee91eb
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spelling	oai:doaj.org-article:028c1db90c9e4f9fab9c0de09fee91eb2021-12-02T14:40:07ZInhibitor binding mode and allosteric regulation of Na + -glucose symporters10.1038/s41467-018-07700-12041-1723https://doaj.org/article/028c1db90c9e4f9fab9c0de09fee91eb2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07700-1https://doaj.org/toc/2041-1723Sodium-dependent glucose transporters (SGLTs) transport sugars across the plasma membrane and play important roles in renal sugar reabsorption. Here authors develop structural models of human SGLT1/2 (hSGLT1/2) in complex with inhibitors which helps to understand inhibitor subtype selectivity.Paola BisignanoChiara GhezziHyunil JoNicholas F. PolizziThorsten AlthoffChakrapani KalyanaramanRosmarie FriemannMatthew P. JacobsonErnest M. WrightMichael GrabeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paola Bisignano Chiara Ghezzi Hyunil Jo Nicholas F. Polizzi Thorsten Althoff Chakrapani Kalyanaraman Rosmarie Friemann Matthew P. Jacobson Ernest M. Wright Michael Grabe Inhibitor binding mode and allosteric regulation of Na + -glucose symporters
description	Sodium-dependent glucose transporters (SGLTs) transport sugars across the plasma membrane and play important roles in renal sugar reabsorption. Here authors develop structural models of human SGLT1/2 (hSGLT1/2) in complex with inhibitors which helps to understand inhibitor subtype selectivity.
format	article
author	Paola Bisignano Chiara Ghezzi Hyunil Jo Nicholas F. Polizzi Thorsten Althoff Chakrapani Kalyanaraman Rosmarie Friemann Matthew P. Jacobson Ernest M. Wright Michael Grabe
author_facet	Paola Bisignano Chiara Ghezzi Hyunil Jo Nicholas F. Polizzi Thorsten Althoff Chakrapani Kalyanaraman Rosmarie Friemann Matthew P. Jacobson Ernest M. Wright Michael Grabe
author_sort	Paola Bisignano
title	Inhibitor binding mode and allosteric regulation of Na + -glucose symporters
title_short	Inhibitor binding mode and allosteric regulation of Na + -glucose symporters
title_full	Inhibitor binding mode and allosteric regulation of Na + -glucose symporters
title_fullStr	Inhibitor binding mode and allosteric regulation of Na + -glucose symporters
title_full_unstemmed	Inhibitor binding mode and allosteric regulation of Na + -glucose symporters
title_sort	inhibitor binding mode and allosteric regulation of na + -glucose symporters
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/028c1db90c9e4f9fab9c0de09fee91eb
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Inhibitor binding mode and allosteric regulation of Na + -glucose symporters

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