A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives

The top down cheminformatics method is usually used for the reconstitution of heterologous pathway to produce plant natural products. Here, the authors report a bottom up computational workflow for the identification of potential products and the enzymes required to make them in a noscapine pathway...

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Autores principales:	Jasmin Hafner, James Payne, Homa MohammadiPeyhani, Vassily Hatzimanikatis, Christina Smolke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/028da8f650b347c08f4dc018f0d40cef
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spelling	oai:doaj.org-article:028da8f650b347c08f4dc018f0d40cef2021-12-02T13:17:40ZA computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives10.1038/s41467-021-22022-52041-1723https://doaj.org/article/028da8f650b347c08f4dc018f0d40cef2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22022-5https://doaj.org/toc/2041-1723The top down cheminformatics method is usually used for the reconstitution of heterologous pathway to produce plant natural products. Here, the authors report a bottom up computational workflow for the identification of potential products and the enzymes required to make them in a noscapine pathway in yeast.Jasmin HafnerJames PayneHoma MohammadiPeyhaniVassily HatzimanikatisChristina SmolkeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jasmin Hafner James Payne Homa MohammadiPeyhani Vassily Hatzimanikatis Christina Smolke A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives
description	The top down cheminformatics method is usually used for the reconstitution of heterologous pathway to produce plant natural products. Here, the authors report a bottom up computational workflow for the identification of potential products and the enzymes required to make them in a noscapine pathway in yeast.
format	article
author	Jasmin Hafner James Payne Homa MohammadiPeyhani Vassily Hatzimanikatis Christina Smolke
author_facet	Jasmin Hafner James Payne Homa MohammadiPeyhani Vassily Hatzimanikatis Christina Smolke
author_sort	Jasmin Hafner
title	A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives
title_short	A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives
title_full	A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives
title_fullStr	A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives
title_full_unstemmed	A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives
title_sort	computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/028da8f650b347c08f4dc018f0d40cef
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A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives

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