Mucosal IL-4R antagonist HIV vaccination with SOSIP-gp140 booster can induce high-quality cytotoxic CD4+/CD8+ T cells and humoral responses in macaques
Abstract Inducing humoral, cellular and mucosal immunity is likely to improve the effectiveness of HIV-1 vaccine strategies. Here, we tested a vaccine regimen in pigtail macaques using an intranasal (i.n.) recombinant Fowl Pox Virus (FPV)-gag pol env-IL-4R antagonist prime, intramuscular (i.m.) reco...
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Autores principales: | Z. Li, M. Khanna, S. L. Grimley, P. Ellenberg, C. A. Gonelli, Wen Shi Lee, T. H. Amarasena, A. D. Kelleher, D. F. J. Purcell, S. J. Kent, C. Ranasinghe |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
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Materias: | |
Acceso en línea: | https://doaj.org/article/0291f314d0d046248dbf0e7b08dc8590 |
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