Investigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome

<h4>Background</h4> Restless Legs Syndrome (RLS) is a neurological sensorimotor disorder that occurs in the evening and night, thereby impacting quality of sleep in sufferers. The pathophysiology of RLS is poorly understood but inflammation has been proposed as possibly being involved. T...

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Autores principales:	Joseph Dowsett, Maria Didriksen, Margit Hørup Larsen, Khoa Manh Dinh, Kathrine Agergård Kaspersen, Susan Mikkelsen, Lise Wegner Thørner, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Jesper Eugen-Olsen, Karina Banasik, Sisse Rye Ostrowski
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/029408922b7c47dcb85abb8585f28cf4
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spelling	oai:doaj.org-article:029408922b7c47dcb85abb8585f28cf42021-11-25T06:11:02ZInvestigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome1932-6203https://doaj.org/article/029408922b7c47dcb85abb8585f28cf42021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589184/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Restless Legs Syndrome (RLS) is a neurological sensorimotor disorder that occurs in the evening and night, thereby impacting quality of sleep in sufferers. The pathophysiology of RLS is poorly understood but inflammation has been proposed as possibly being involved. The neutrophil-to-lymphocyte ratio (NLR) can be used as an inflammation marker but results from small studies have been inconclusive in determining whether NLR is associated with RLS. We aimed to assess whether an association between NLR and RLS exists in a large cohort of healthy individuals. <h4>Methods</h4> Neutrophils and lymphocytes were measured in blood samples of 13,055 individuals from the Danish Blood Donor Study, all of whom completed the validated Cambridge-Hopkins RLS-questionnaire for RLS assessment. <h4>Results</h4> In the sample, 661 individuals were determined as current RLS cases (5.1%). A higher proportion of individuals with RLS were females (62.5% vs 47.5%; P<0.001) and RLS cases were older than controls (P<0.001), but no differences in body mass index (BMI), smoking or alcohol consumption were found between the two groups. An increased NLR was observed in RLS cases compared to controls (median NLR: 1.80 vs 1.72; P = 0.033). In an unadjusted logistic regression model, increased NLR was associated with RLS (OR = 1.10 per NLR unit increase [95%CI:1.01–1.20]; P = 0.032); however, the association was not significant in multivariate models adjusting for sex and age (P = 0.094) or sex, age, alcohol consumption, smoking status and BMI (P = 0.107). <h4>Conclusion</h4> We found no association between RLS and NLR among Danish blood donors after adjusting for sex, age, alcohol consumption, smoking status and BMI. Further studies are needed to determine whether inflammation is a risk factor for RLS.Joseph DowsettMaria DidriksenMargit Hørup LarsenKhoa Manh DinhKathrine Agergård KaspersenSusan MikkelsenLise Wegner ThørnerErik SørensenChristian ErikstrupOle Birger PedersenJesper Eugen-OlsenKarina BanasikSisse Rye OstrowskiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph Dowsett Maria Didriksen Margit Hørup Larsen Khoa Manh Dinh Kathrine Agergård Kaspersen Susan Mikkelsen Lise Wegner Thørner Erik Sørensen Christian Erikstrup Ole Birger Pedersen Jesper Eugen-Olsen Karina Banasik Sisse Rye Ostrowski Investigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome
description	<h4>Background</h4> Restless Legs Syndrome (RLS) is a neurological sensorimotor disorder that occurs in the evening and night, thereby impacting quality of sleep in sufferers. The pathophysiology of RLS is poorly understood but inflammation has been proposed as possibly being involved. The neutrophil-to-lymphocyte ratio (NLR) can be used as an inflammation marker but results from small studies have been inconclusive in determining whether NLR is associated with RLS. We aimed to assess whether an association between NLR and RLS exists in a large cohort of healthy individuals. <h4>Methods</h4> Neutrophils and lymphocytes were measured in blood samples of 13,055 individuals from the Danish Blood Donor Study, all of whom completed the validated Cambridge-Hopkins RLS-questionnaire for RLS assessment. <h4>Results</h4> In the sample, 661 individuals were determined as current RLS cases (5.1%). A higher proportion of individuals with RLS were females (62.5% vs 47.5%; P<0.001) and RLS cases were older than controls (P<0.001), but no differences in body mass index (BMI), smoking or alcohol consumption were found between the two groups. An increased NLR was observed in RLS cases compared to controls (median NLR: 1.80 vs 1.72; P = 0.033). In an unadjusted logistic regression model, increased NLR was associated with RLS (OR = 1.10 per NLR unit increase [95%CI:1.01–1.20]; P = 0.032); however, the association was not significant in multivariate models adjusting for sex and age (P = 0.094) or sex, age, alcohol consumption, smoking status and BMI (P = 0.107). <h4>Conclusion</h4> We found no association between RLS and NLR among Danish blood donors after adjusting for sex, age, alcohol consumption, smoking status and BMI. Further studies are needed to determine whether inflammation is a risk factor for RLS.
format	article
author	Joseph Dowsett Maria Didriksen Margit Hørup Larsen Khoa Manh Dinh Kathrine Agergård Kaspersen Susan Mikkelsen Lise Wegner Thørner Erik Sørensen Christian Erikstrup Ole Birger Pedersen Jesper Eugen-Olsen Karina Banasik Sisse Rye Ostrowski
author_facet	Joseph Dowsett Maria Didriksen Margit Hørup Larsen Khoa Manh Dinh Kathrine Agergård Kaspersen Susan Mikkelsen Lise Wegner Thørner Erik Sørensen Christian Erikstrup Ole Birger Pedersen Jesper Eugen-Olsen Karina Banasik Sisse Rye Ostrowski
author_sort	Joseph Dowsett
title	Investigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome
title_short	Investigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome
title_full	Investigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome
title_fullStr	Investigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome
title_full_unstemmed	Investigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome
title_sort	investigating the inflammation marker neutrophil-to-lymphocyte ratio in danish blood donors with restless legs syndrome
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/029408922b7c47dcb85abb8585f28cf4
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Investigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome

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