Association between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study

Abstract Metabolic consequences of an energy and protein rich diet can compromise metabolic health of cattle by promoting a pro-inflammatory phenotype. Laminitis is a common clinical sign, but affected metabolic pathways, underlying pathophysiology and causative relationships of a systemic pro-infla...

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Autores principales:	Sonja Christiane Bäßler, Ákos Kenéz, Theresa Scheu, Christian Koch, Ulrich Meyer, Sven Dänicke, Korinna Huber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/029ab69f98bd4780b1d250b066107202
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spelling	oai:doaj.org-article:029ab69f98bd4780b1d250b0661072022021-12-02T17:40:01ZAssociation between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study10.1038/s41598-021-92163-62045-2322https://doaj.org/article/029ab69f98bd4780b1d250b0661072022021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92163-6https://doaj.org/toc/2045-2322Abstract Metabolic consequences of an energy and protein rich diet can compromise metabolic health of cattle by promoting a pro-inflammatory phenotype. Laminitis is a common clinical sign, but affected metabolic pathways, underlying pathophysiology and causative relationships of a systemic pro-inflammatory phenotype are unclear. Therefore, the aim of this study was to elucidate changes in metabolome profiles of 20 months old Holstein bulls fed a high energy and protein diet and to identify novel metabolites and affected pathways, associated with diet-related laminitis. In a randomized controlled feeding trial using bulls fed a high energy and protein diet (HEP; metabolizable energy [ME] intake 169.0 ± 1.4 MJ/day; crude protein [CP] intake 2.3 ± 0.02 kg/day; calculated means ± SEM; n = 15) versus a low energy and protein diet (LEP; ME intake 92.9 ± 1.3 MJ/day; CP intake 1.0 ± 0.01 kg/day; n = 15), wide ranging effects of HEP diet on metabolism were demonstrated with a targeted metabolomics approach using the AbsoluteIDQ p180 kit (Biocrates Life Sciences). Multivariate statistics revealed that lower concentrations of phosphatidylcholines and sphingomyelins and higher concentrations of lyso-phosphatidylcholines, branched chain amino acids and aromatic amino acids were associated with an inflammatory state of diet-related laminitis in Holstein bulls fed a HEP diet. The latter two metabolites share similarities with changes in metabolism of obese humans, indicating a conserved pathophysiological role. The observed alterations in the metabolome provide further explanation on the underlying metabolic consequences of excessive dietary nutrient intake.Sonja Christiane BäßlerÁkos KenézTheresa ScheuChristian KochUlrich MeyerSven DänickeKorinna HuberNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sonja Christiane Bäßler Ákos Kenéz Theresa Scheu Christian Koch Ulrich Meyer Sven Dänicke Korinna Huber Association between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study
description	Abstract Metabolic consequences of an energy and protein rich diet can compromise metabolic health of cattle by promoting a pro-inflammatory phenotype. Laminitis is a common clinical sign, but affected metabolic pathways, underlying pathophysiology and causative relationships of a systemic pro-inflammatory phenotype are unclear. Therefore, the aim of this study was to elucidate changes in metabolome profiles of 20 months old Holstein bulls fed a high energy and protein diet and to identify novel metabolites and affected pathways, associated with diet-related laminitis. In a randomized controlled feeding trial using bulls fed a high energy and protein diet (HEP; metabolizable energy [ME] intake 169.0 ± 1.4 MJ/day; crude protein [CP] intake 2.3 ± 0.02 kg/day; calculated means ± SEM; n = 15) versus a low energy and protein diet (LEP; ME intake 92.9 ± 1.3 MJ/day; CP intake 1.0 ± 0.01 kg/day; n = 15), wide ranging effects of HEP diet on metabolism were demonstrated with a targeted metabolomics approach using the AbsoluteIDQ p180 kit (Biocrates Life Sciences). Multivariate statistics revealed that lower concentrations of phosphatidylcholines and sphingomyelins and higher concentrations of lyso-phosphatidylcholines, branched chain amino acids and aromatic amino acids were associated with an inflammatory state of diet-related laminitis in Holstein bulls fed a HEP diet. The latter two metabolites share similarities with changes in metabolism of obese humans, indicating a conserved pathophysiological role. The observed alterations in the metabolome provide further explanation on the underlying metabolic consequences of excessive dietary nutrient intake.
format	article
author	Sonja Christiane Bäßler Ákos Kenéz Theresa Scheu Christian Koch Ulrich Meyer Sven Dänicke Korinna Huber
author_facet	Sonja Christiane Bäßler Ákos Kenéz Theresa Scheu Christian Koch Ulrich Meyer Sven Dänicke Korinna Huber
author_sort	Sonja Christiane Bäßler
title	Association between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study
title_short	Association between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study
title_full	Association between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study
title_fullStr	Association between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study
title_full_unstemmed	Association between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study
title_sort	association between alterations in plasma metabolome profiles and laminitis in intensively finished holstein bulls in a randomized controlled study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/029ab69f98bd4780b1d250b066107202
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Association between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study

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