New-onset lesions on MRI-DWI and cerebral blood flow changes on 3D-pCASL after carotid artery stenting

Abstract This study aimed to investigate the relationship between the new-onset hyperintense lesions on diffusion-weighted images (DWI) and the changes of cerebral blood flow (CBF) before and after carotid artery stenting (CAS) in patients with symptomatic unilateral carotid artery stenosis. Twenty-...

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Autores principales:	Wen-Xin Wang, Ting Wang, Lin Ma, Zheng-Hui Sun, Ge-Sheng Wang, Xin Lou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/029bdc1d8b4b46ecbdd4669b7d269721
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spelling	oai:doaj.org-article:029bdc1d8b4b46ecbdd4669b7d2697212021-12-02T14:26:25ZNew-onset lesions on MRI-DWI and cerebral blood flow changes on 3D-pCASL after carotid artery stenting10.1038/s41598-021-87339-z2045-2322https://doaj.org/article/029bdc1d8b4b46ecbdd4669b7d2697212021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87339-zhttps://doaj.org/toc/2045-2322Abstract This study aimed to investigate the relationship between the new-onset hyperintense lesions on diffusion-weighted images (DWI) and the changes of cerebral blood flow (CBF) before and after carotid artery stenting (CAS) in patients with symptomatic unilateral carotid artery stenosis. Twenty-four patients with symptomatic unilateral carotid stenosis (50–99%) were enrolled. Routine head magnetic resonance imaging and three-dimensional pseudo-continuous arterial spin labeling were taken 7 days before the surgery and for four consecutive days post CAS. While the incidence of new DWI lesions were high (17/24, 70.8%) and 176 lesions were observed among the 17 cases, there was only one subject showing the symptoms. The majority of the lesions were located at the cortex/subcortex of the ipsilateral frontal and parietal lobes (60.8%) with 92.6% of the lesions size being less than 3 mm. The CBFs in this area were significantly higher than that of the temporal lobe on the first 3 days post stenting (p < 0.05). No periprocedural CBF differences were observed between the two groups, however, the micro-embolism group presented decreased relative CBF in frontal and parietal lobes prior to stenting compared with the non-embolism group. The systolic blood pressure in the micro-embolism group at discharge was significantly lower than that at admission. The high incidence rate of micro-embolism in patients receiving CAS may not be the result of direct changes of hemodynamics in the brain but rather the loss of CBF regulation due to long-term hypoperfusion prior to the stenting.Wen-Xin WangTing WangLin MaZheng-Hui SunGe-Sheng WangXin LouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wen-Xin Wang Ting Wang Lin Ma Zheng-Hui Sun Ge-Sheng Wang Xin Lou New-onset lesions on MRI-DWI and cerebral blood flow changes on 3D-pCASL after carotid artery stenting
description	Abstract This study aimed to investigate the relationship between the new-onset hyperintense lesions on diffusion-weighted images (DWI) and the changes of cerebral blood flow (CBF) before and after carotid artery stenting (CAS) in patients with symptomatic unilateral carotid artery stenosis. Twenty-four patients with symptomatic unilateral carotid stenosis (50–99%) were enrolled. Routine head magnetic resonance imaging and three-dimensional pseudo-continuous arterial spin labeling were taken 7 days before the surgery and for four consecutive days post CAS. While the incidence of new DWI lesions were high (17/24, 70.8%) and 176 lesions were observed among the 17 cases, there was only one subject showing the symptoms. The majority of the lesions were located at the cortex/subcortex of the ipsilateral frontal and parietal lobes (60.8%) with 92.6% of the lesions size being less than 3 mm. The CBFs in this area were significantly higher than that of the temporal lobe on the first 3 days post stenting (p < 0.05). No periprocedural CBF differences were observed between the two groups, however, the micro-embolism group presented decreased relative CBF in frontal and parietal lobes prior to stenting compared with the non-embolism group. The systolic blood pressure in the micro-embolism group at discharge was significantly lower than that at admission. The high incidence rate of micro-embolism in patients receiving CAS may not be the result of direct changes of hemodynamics in the brain but rather the loss of CBF regulation due to long-term hypoperfusion prior to the stenting.
format	article
author	Wen-Xin Wang Ting Wang Lin Ma Zheng-Hui Sun Ge-Sheng Wang Xin Lou
author_facet	Wen-Xin Wang Ting Wang Lin Ma Zheng-Hui Sun Ge-Sheng Wang Xin Lou
author_sort	Wen-Xin Wang
title	New-onset lesions on MRI-DWI and cerebral blood flow changes on 3D-pCASL after carotid artery stenting
title_short	New-onset lesions on MRI-DWI and cerebral blood flow changes on 3D-pCASL after carotid artery stenting
title_full	New-onset lesions on MRI-DWI and cerebral blood flow changes on 3D-pCASL after carotid artery stenting
title_fullStr	New-onset lesions on MRI-DWI and cerebral blood flow changes on 3D-pCASL after carotid artery stenting
title_full_unstemmed	New-onset lesions on MRI-DWI and cerebral blood flow changes on 3D-pCASL after carotid artery stenting
title_sort	new-onset lesions on mri-dwi and cerebral blood flow changes on 3d-pcasl after carotid artery stenting
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/029bdc1d8b4b46ecbdd4669b7d269721
work_keys_str_mv	AT wenxinwang newonsetlesionsonmridwiandcerebralbloodflowchangeson3dpcaslaftercarotidarterystenting AT tingwang newonsetlesionsonmridwiandcerebralbloodflowchangeson3dpcaslaftercarotidarterystenting AT linma newonsetlesionsonmridwiandcerebralbloodflowchangeson3dpcaslaftercarotidarterystenting AT zhenghuisun newonsetlesionsonmridwiandcerebralbloodflowchangeson3dpcaslaftercarotidarterystenting AT geshengwang newonsetlesionsonmridwiandcerebralbloodflowchangeson3dpcaslaftercarotidarterystenting AT xinlou newonsetlesionsonmridwiandcerebralbloodflowchangeson3dpcaslaftercarotidarterystenting
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New-onset lesions on MRI-DWI and cerebral blood flow changes on 3D-pCASL after carotid artery stenting

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