Substrate-induced conformational dynamics of the dopamine transporter

The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced conformational dynamics of the dopamine trans...

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Autores principales:	Anne Kathrine Nielsen, Ingvar R. Möller, Yong Wang, Søren G. F. Rasmussen, Kresten Lindorff-Larsen, Kasper D. Rand, Claus J. Loland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/029ceb9db51c4981be407b2faa05bd7d
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spelling	oai:doaj.org-article:029ceb9db51c4981be407b2faa05bd7d2021-12-02T16:51:01ZSubstrate-induced conformational dynamics of the dopamine transporter10.1038/s41467-019-10449-w2041-1723https://doaj.org/article/029ceb9db51c4981be407b2faa05bd7d2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10449-whttps://doaj.org/toc/2041-1723The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced conformational dynamics of the dopamine transporter.Anne Kathrine NielsenIngvar R. MöllerYong WangSøren G. F. RasmussenKresten Lindorff-LarsenKasper D. RandClaus J. LolandNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anne Kathrine Nielsen Ingvar R. Möller Yong Wang Søren G. F. Rasmussen Kresten Lindorff-Larsen Kasper D. Rand Claus J. Loland Substrate-induced conformational dynamics of the dopamine transporter
description	The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced conformational dynamics of the dopamine transporter.
format	article
author	Anne Kathrine Nielsen Ingvar R. Möller Yong Wang Søren G. F. Rasmussen Kresten Lindorff-Larsen Kasper D. Rand Claus J. Loland
author_facet	Anne Kathrine Nielsen Ingvar R. Möller Yong Wang Søren G. F. Rasmussen Kresten Lindorff-Larsen Kasper D. Rand Claus J. Loland
author_sort	Anne Kathrine Nielsen
title	Substrate-induced conformational dynamics of the dopamine transporter
title_short	Substrate-induced conformational dynamics of the dopamine transporter
title_full	Substrate-induced conformational dynamics of the dopamine transporter
title_fullStr	Substrate-induced conformational dynamics of the dopamine transporter
title_full_unstemmed	Substrate-induced conformational dynamics of the dopamine transporter
title_sort	substrate-induced conformational dynamics of the dopamine transporter
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/029ceb9db51c4981be407b2faa05bd7d
work_keys_str_mv	AT annekathrinenielsen substrateinducedconformationaldynamicsofthedopaminetransporter AT ingvarrmoller substrateinducedconformationaldynamicsofthedopaminetransporter AT yongwang substrateinducedconformationaldynamicsofthedopaminetransporter AT sørengfrasmussen substrateinducedconformationaldynamicsofthedopaminetransporter AT krestenlindorfflarsen substrateinducedconformationaldynamicsofthedopaminetransporter AT kasperdrand substrateinducedconformationaldynamicsofthedopaminetransporter AT clausjloland substrateinducedconformationaldynamicsofthedopaminetransporter
_version_	1718382958136524800

Substrate-induced conformational dynamics of the dopamine transporter

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