Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis
Knottin is a cystine knot peptide. Here, the authors develop a knottin-based tracer for positron emission tomography and demonstrate its ability to detect cancer and idiopathic pulmonary fibrosis through selective binding to integrin αvβ6.
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Nature Portfolio
2019
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oai:doaj.org-article:029f63b5dea042f582dd348aecf36a8e2021-12-02T16:57:11ZEvaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis10.1038/s41467-019-11863-w2041-1723https://doaj.org/article/029f63b5dea042f582dd348aecf36a8e2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11863-whttps://doaj.org/toc/2041-1723Knottin is a cystine knot peptide. Here, the authors develop a knottin-based tracer for positron emission tomography and demonstrate its ability to detect cancer and idiopathic pulmonary fibrosis through selective binding to integrin αvβ6.Richard H. KimuraLing WangBin ShenLi HuoWillemieke TummersFabian V. FilippHaiwei Henry GuoThomas HaywoodLotfi Abou-ElkacemLucia BarattoFrezghi HabteRammohan DevulapallyTimothy H. WitneyYan ChengSuhas TikoleSubhendu ChakrabortiJay NixChristopher A. BonaguraNegin HatamiJoshua J. MooneyTushar DesaiScott TurnerRichard S. GasterAndrea OtteBrendan C. VisserGeorge A. PoultsidesJeffrey NortonWalter ParkMark StolowitzKenneth LauEric YangArutselvan NatarajanOhad IlovichShyam SrinivasAnanth SrinivasanRamasamy PaulmuruganJuergen WillmannFrederick T. ChinZhen ChengAndrei IagaruFang LiSanjiv S. GambhirNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
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Science Q |
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Science Q Richard H. Kimura Ling Wang Bin Shen Li Huo Willemieke Tummers Fabian V. Filipp Haiwei Henry Guo Thomas Haywood Lotfi Abou-Elkacem Lucia Baratto Frezghi Habte Rammohan Devulapally Timothy H. Witney Yan Cheng Suhas Tikole Subhendu Chakraborti Jay Nix Christopher A. Bonagura Negin Hatami Joshua J. Mooney Tushar Desai Scott Turner Richard S. Gaster Andrea Otte Brendan C. Visser George A. Poultsides Jeffrey Norton Walter Park Mark Stolowitz Kenneth Lau Eric Yang Arutselvan Natarajan Ohad Ilovich Shyam Srinivas Ananth Srinivasan Ramasamy Paulmurugan Juergen Willmann Frederick T. Chin Zhen Cheng Andrei Iagaru Fang Li Sanjiv S. Gambhir Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis |
| description |
Knottin is a cystine knot peptide. Here, the authors develop a knottin-based tracer for positron emission tomography and demonstrate its ability to detect cancer and idiopathic pulmonary fibrosis through selective binding to integrin αvβ6. |
| format |
article |
| author |
Richard H. Kimura Ling Wang Bin Shen Li Huo Willemieke Tummers Fabian V. Filipp Haiwei Henry Guo Thomas Haywood Lotfi Abou-Elkacem Lucia Baratto Frezghi Habte Rammohan Devulapally Timothy H. Witney Yan Cheng Suhas Tikole Subhendu Chakraborti Jay Nix Christopher A. Bonagura Negin Hatami Joshua J. Mooney Tushar Desai Scott Turner Richard S. Gaster Andrea Otte Brendan C. Visser George A. Poultsides Jeffrey Norton Walter Park Mark Stolowitz Kenneth Lau Eric Yang Arutselvan Natarajan Ohad Ilovich Shyam Srinivas Ananth Srinivasan Ramasamy Paulmurugan Juergen Willmann Frederick T. Chin Zhen Cheng Andrei Iagaru Fang Li Sanjiv S. Gambhir |
| author_facet |
Richard H. Kimura Ling Wang Bin Shen Li Huo Willemieke Tummers Fabian V. Filipp Haiwei Henry Guo Thomas Haywood Lotfi Abou-Elkacem Lucia Baratto Frezghi Habte Rammohan Devulapally Timothy H. Witney Yan Cheng Suhas Tikole Subhendu Chakraborti Jay Nix Christopher A. Bonagura Negin Hatami Joshua J. Mooney Tushar Desai Scott Turner Richard S. Gaster Andrea Otte Brendan C. Visser George A. Poultsides Jeffrey Norton Walter Park Mark Stolowitz Kenneth Lau Eric Yang Arutselvan Natarajan Ohad Ilovich Shyam Srinivas Ananth Srinivasan Ramasamy Paulmurugan Juergen Willmann Frederick T. Chin Zhen Cheng Andrei Iagaru Fang Li Sanjiv S. Gambhir |
| author_sort |
Richard H. Kimura |
| title |
Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis |
| title_short |
Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis |
| title_full |
Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis |
| title_fullStr |
Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis |
| title_full_unstemmed |
Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis |
| title_sort |
evaluation of integrin αvβ6 cystine knot pet tracers to detect cancer and idiopathic pulmonary fibrosis |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/029f63b5dea042f582dd348aecf36a8e |
| work_keys_str_mv |
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