Preservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor.

Brain-derived neurotrophic factor (BDNF) promotes survival and synaptic plasticity in the human brain. The Val66Met polymorphism of the BDNF gene interferes with intracellular trafficking, packaging, and regulated secretion of this neurotrophin. The human prefrontal cortex (PFC) shows lifelong neuro...

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Autores principales:	Aron K Barbey, Roberto Colom, Erick Paul, Chad Forbes, Frank Krueger, David Goldman, Jordan Grafman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/029f7e6852f145728cf686a71fb75669
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spelling	oai:doaj.org-article:029f7e6852f145728cf686a71fb756692021-11-18T08:30:59ZPreservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor.1932-620310.1371/journal.pone.0088733https://doaj.org/article/029f7e6852f145728cf686a71fb756692014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586380/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Brain-derived neurotrophic factor (BDNF) promotes survival and synaptic plasticity in the human brain. The Val66Met polymorphism of the BDNF gene interferes with intracellular trafficking, packaging, and regulated secretion of this neurotrophin. The human prefrontal cortex (PFC) shows lifelong neuroplastic adaption implicating the Val66Met BDNF polymorphism in the recovery of higher-order executive functions after traumatic brain injury (TBI). In this study, we examined the effect of this BDNF polymorphism on the preservation of general intelligence following TBI. We genotyped a sample of male Vietnam combat veterans (n = 156) consisting of a frontal lobe lesion group with focal penetrating head injuries for the Val66Met BDNF polymorphism. Val/Met did not differ from Val/Val genotypes in general cognitive ability before TBI. However, we found substantial average differences between these groups in general intelligence (≈ half a standard deviation or 8 IQ points), verbal comprehension (6 IQ points), perceptual organization (6 IQ points), working memory (8 IQ points), and processing speed (8 IQ points) after TBI. These results support the conclusion that Val/Met genotypes preserve general cognitive functioning, whereas Val/Val genotypes are largely susceptible to TBI.Aron K BarbeyRoberto ColomErick PaulChad ForbesFrank KruegerDavid GoldmanJordan GrafmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88733 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aron K Barbey Roberto Colom Erick Paul Chad Forbes Frank Krueger David Goldman Jordan Grafman Preservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor.
description	Brain-derived neurotrophic factor (BDNF) promotes survival and synaptic plasticity in the human brain. The Val66Met polymorphism of the BDNF gene interferes with intracellular trafficking, packaging, and regulated secretion of this neurotrophin. The human prefrontal cortex (PFC) shows lifelong neuroplastic adaption implicating the Val66Met BDNF polymorphism in the recovery of higher-order executive functions after traumatic brain injury (TBI). In this study, we examined the effect of this BDNF polymorphism on the preservation of general intelligence following TBI. We genotyped a sample of male Vietnam combat veterans (n = 156) consisting of a frontal lobe lesion group with focal penetrating head injuries for the Val66Met BDNF polymorphism. Val/Met did not differ from Val/Val genotypes in general cognitive ability before TBI. However, we found substantial average differences between these groups in general intelligence (≈ half a standard deviation or 8 IQ points), verbal comprehension (6 IQ points), perceptual organization (6 IQ points), working memory (8 IQ points), and processing speed (8 IQ points) after TBI. These results support the conclusion that Val/Met genotypes preserve general cognitive functioning, whereas Val/Val genotypes are largely susceptible to TBI.
format	article
author	Aron K Barbey Roberto Colom Erick Paul Chad Forbes Frank Krueger David Goldman Jordan Grafman
author_facet	Aron K Barbey Roberto Colom Erick Paul Chad Forbes Frank Krueger David Goldman Jordan Grafman
author_sort	Aron K Barbey
title	Preservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor.
title_short	Preservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor.
title_full	Preservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor.
title_fullStr	Preservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor.
title_full_unstemmed	Preservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor.
title_sort	preservation of general intelligence following traumatic brain injury: contributions of the met66 brain-derived neurotrophic factor.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/029f7e6852f145728cf686a71fb75669
work_keys_str_mv	AT aronkbarbey preservationofgeneralintelligencefollowingtraumaticbraininjurycontributionsofthemet66brainderivedneurotrophicfactor AT robertocolom preservationofgeneralintelligencefollowingtraumaticbraininjurycontributionsofthemet66brainderivedneurotrophicfactor AT erickpaul preservationofgeneralintelligencefollowingtraumaticbraininjurycontributionsofthemet66brainderivedneurotrophicfactor AT chadforbes preservationofgeneralintelligencefollowingtraumaticbraininjurycontributionsofthemet66brainderivedneurotrophicfactor AT frankkrueger preservationofgeneralintelligencefollowingtraumaticbraininjurycontributionsofthemet66brainderivedneurotrophicfactor AT davidgoldman preservationofgeneralintelligencefollowingtraumaticbraininjurycontributionsofthemet66brainderivedneurotrophicfactor AT jordangrafman preservationofgeneralintelligencefollowingtraumaticbraininjurycontributionsofthemet66brainderivedneurotrophicfactor
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Preservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor.

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