The neglected intrinsic resistome of bacterial pathogens.
Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence of cellular impermeability and activity of efflux pumps. However, the analysis of transposon-tagged Pseudomona...
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2008
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oai:doaj.org-article:02a0174bae9b46e9a935065038cc8dec2021-11-25T06:13:22ZThe neglected intrinsic resistome of bacterial pathogens.1932-620310.1371/journal.pone.0001619https://doaj.org/article/02a0174bae9b46e9a935065038cc8dec2008-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18286176/?tool=EBIhttps://doaj.org/toc/1932-6203Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence of cellular impermeability and activity of efflux pumps. However, the analysis of transposon-tagged Pseudomonas aeruginosa mutants presented in this article shows that this phenotype emerges from the action of numerous proteins from all functional categories. Mutations in some genes make P. aeruginosa more susceptible to antibiotics and thereby represent new targets. Mutations in other genes make P. aeruginosa more resistant and therefore define novel mechanisms for mutation-driven acquisition of antibiotic resistance, opening a new research field based in the prediction of resistance before it emerges in clinical environments. Antibiotics are not just weapons against bacterial competitors, but also natural signalling molecules. Our results demonstrate that antibiotic resistance genes are not merely protective shields and offer a more comprehensive view of the role of antibiotic resistance genes in the clinic and in nature.Alicia FajardoNadia Martínez-MartínMaría MercadilloJuan C GalánBart GhyselsSandra MatthijsPierre CornelisLutz WiehlmannBurkhard TümmlerFernando BaqueroJosé L MartínezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 2, p e1619 (2008) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Alicia Fajardo Nadia Martínez-Martín María Mercadillo Juan C Galán Bart Ghysels Sandra Matthijs Pierre Cornelis Lutz Wiehlmann Burkhard Tümmler Fernando Baquero José L Martínez The neglected intrinsic resistome of bacterial pathogens. |
| description |
Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence of cellular impermeability and activity of efflux pumps. However, the analysis of transposon-tagged Pseudomonas aeruginosa mutants presented in this article shows that this phenotype emerges from the action of numerous proteins from all functional categories. Mutations in some genes make P. aeruginosa more susceptible to antibiotics and thereby represent new targets. Mutations in other genes make P. aeruginosa more resistant and therefore define novel mechanisms for mutation-driven acquisition of antibiotic resistance, opening a new research field based in the prediction of resistance before it emerges in clinical environments. Antibiotics are not just weapons against bacterial competitors, but also natural signalling molecules. Our results demonstrate that antibiotic resistance genes are not merely protective shields and offer a more comprehensive view of the role of antibiotic resistance genes in the clinic and in nature. |
| format |
article |
| author |
Alicia Fajardo Nadia Martínez-Martín María Mercadillo Juan C Galán Bart Ghysels Sandra Matthijs Pierre Cornelis Lutz Wiehlmann Burkhard Tümmler Fernando Baquero José L Martínez |
| author_facet |
Alicia Fajardo Nadia Martínez-Martín María Mercadillo Juan C Galán Bart Ghysels Sandra Matthijs Pierre Cornelis Lutz Wiehlmann Burkhard Tümmler Fernando Baquero José L Martínez |
| author_sort |
Alicia Fajardo |
| title |
The neglected intrinsic resistome of bacterial pathogens. |
| title_short |
The neglected intrinsic resistome of bacterial pathogens. |
| title_full |
The neglected intrinsic resistome of bacterial pathogens. |
| title_fullStr |
The neglected intrinsic resistome of bacterial pathogens. |
| title_full_unstemmed |
The neglected intrinsic resistome of bacterial pathogens. |
| title_sort |
neglected intrinsic resistome of bacterial pathogens. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2008 |
| url |
https://doaj.org/article/02a0174bae9b46e9a935065038cc8dec |
| work_keys_str_mv |
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