Pre-stroke apathy symptoms are associated with an increased risk of delirium in stroke patients

Abstract Neuropsychiatric symptoms can be interrelated to delirium. We aimed to investigate an association between pre-stroke neuropsychiatric symptoms and the risk of delirium in stroke patients. We included 606 patients (median age: 73, 53% female) with stroke or transient ischemic attack admitted...

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Autores principales:	Elzbieta Klimiec, Katarzyna Kowalska, Paulina Pasinska, Aleksandra Klimkowicz-Mrowiec, Aleksandra Szyper, Joanna Pera, Agnieszka Slowik, Tomasz Dziedzic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/02a08be061a347b99668b59ea1e99d38
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spelling	oai:doaj.org-article:02a08be061a347b99668b59ea1e99d382021-12-02T11:53:12ZPre-stroke apathy symptoms are associated with an increased risk of delirium in stroke patients10.1038/s41598-017-08087-72045-2322https://doaj.org/article/02a08be061a347b99668b59ea1e99d382017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08087-7https://doaj.org/toc/2045-2322Abstract Neuropsychiatric symptoms can be interrelated to delirium. We aimed to investigate an association between pre-stroke neuropsychiatric symptoms and the risk of delirium in stroke patients. We included 606 patients (median age: 73, 53% female) with stroke or transient ischemic attack admitted within 48 hours from symptoms onset. We assessed delirium on a daily basis during the first 7 days of hospitalization. To make diagnosis of delirium we used DSM-5 criteria. We used Neuropsychiatric Inventory to assess neuropsychiatric symptoms occurring within 4 weeks prior to stroke. We diagnosed delirium in 28.2% of patients. On univariate analysis, higher score of pre-stroke depression (OR: 1.58, 95% CI: 1.04–2.40, P = 0.03), apathy (OR: 2.23, 95% CI: 1.44–3.45, P < 0.01), delusions (OR: 2.00, 95% CI: 1.09–3.68, P = 0.03), hallucinations (OR: 2.39, 95% CI: 1.19–4.81, P = 0.01) and disinhibition (OR: 2.10, 95% CI: 1.04–4.25, P = 0.04) was associated with the increased risk of delirium. On multivariate analysis adjusted for age, atrial fibrillation, diabetes mellitus, stroke severity, right hemisphere lesion, pre-stroke cognitive decline, pre-stroke disability and infections, higher apathy score (OR: 2.03, 95% CI: 1.17–3.50, P = 0.01), but no other neuropsychiatric symptoms, remained independent predictor of delirium. We conclude that pre-stroke apathy symptoms are associated with increased risk of delirium in stroke patients.Elzbieta KlimiecKatarzyna KowalskaPaulina PasinskaAleksandra Klimkowicz-MrowiecAleksandra SzyperJoanna PeraAgnieszka SlowikTomasz DziedzicNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elzbieta Klimiec Katarzyna Kowalska Paulina Pasinska Aleksandra Klimkowicz-Mrowiec Aleksandra Szyper Joanna Pera Agnieszka Slowik Tomasz Dziedzic Pre-stroke apathy symptoms are associated with an increased risk of delirium in stroke patients
description	Abstract Neuropsychiatric symptoms can be interrelated to delirium. We aimed to investigate an association between pre-stroke neuropsychiatric symptoms and the risk of delirium in stroke patients. We included 606 patients (median age: 73, 53% female) with stroke or transient ischemic attack admitted within 48 hours from symptoms onset. We assessed delirium on a daily basis during the first 7 days of hospitalization. To make diagnosis of delirium we used DSM-5 criteria. We used Neuropsychiatric Inventory to assess neuropsychiatric symptoms occurring within 4 weeks prior to stroke. We diagnosed delirium in 28.2% of patients. On univariate analysis, higher score of pre-stroke depression (OR: 1.58, 95% CI: 1.04–2.40, P = 0.03), apathy (OR: 2.23, 95% CI: 1.44–3.45, P < 0.01), delusions (OR: 2.00, 95% CI: 1.09–3.68, P = 0.03), hallucinations (OR: 2.39, 95% CI: 1.19–4.81, P = 0.01) and disinhibition (OR: 2.10, 95% CI: 1.04–4.25, P = 0.04) was associated with the increased risk of delirium. On multivariate analysis adjusted for age, atrial fibrillation, diabetes mellitus, stroke severity, right hemisphere lesion, pre-stroke cognitive decline, pre-stroke disability and infections, higher apathy score (OR: 2.03, 95% CI: 1.17–3.50, P = 0.01), but no other neuropsychiatric symptoms, remained independent predictor of delirium. We conclude that pre-stroke apathy symptoms are associated with increased risk of delirium in stroke patients.
format	article
author	Elzbieta Klimiec Katarzyna Kowalska Paulina Pasinska Aleksandra Klimkowicz-Mrowiec Aleksandra Szyper Joanna Pera Agnieszka Slowik Tomasz Dziedzic
author_facet	Elzbieta Klimiec Katarzyna Kowalska Paulina Pasinska Aleksandra Klimkowicz-Mrowiec Aleksandra Szyper Joanna Pera Agnieszka Slowik Tomasz Dziedzic
author_sort	Elzbieta Klimiec
title	Pre-stroke apathy symptoms are associated with an increased risk of delirium in stroke patients
title_short	Pre-stroke apathy symptoms are associated with an increased risk of delirium in stroke patients
title_full	Pre-stroke apathy symptoms are associated with an increased risk of delirium in stroke patients
title_fullStr	Pre-stroke apathy symptoms are associated with an increased risk of delirium in stroke patients
title_full_unstemmed	Pre-stroke apathy symptoms are associated with an increased risk of delirium in stroke patients
title_sort	pre-stroke apathy symptoms are associated with an increased risk of delirium in stroke patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/02a08be061a347b99668b59ea1e99d38
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Pre-stroke apathy symptoms are associated with an increased risk of delirium in stroke patients

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