O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity

Post-translational O-linked β-N acetylglucosamine (O-GlcNAc) modification acts as a nutrient-sensing mechanism. Here the authors report that O-GlcNAc transferase inhibits adipose tissue lipolysis via O-GlcNAcylation of the lipid droplet protein perilipin 1 and thus promotes diet-induced obesity.

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Autores principales:	Yunfan Yang, Minnie Fu, Min-Dian Li, Kaisi Zhang, Bichen Zhang, Simeng Wang, Yuyang Liu, Weiming Ni, Qunxiang Ong, Jia Mi, Xiaoyong Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/02a0ca40f2d6493cae075a4260c04f9c
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spelling	oai:doaj.org-article:02a0ca40f2d6493cae075a4260c04f9c2021-12-02T15:39:12ZO-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity10.1038/s41467-019-13914-82041-1723https://doaj.org/article/02a0ca40f2d6493cae075a4260c04f9c2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13914-8https://doaj.org/toc/2041-1723Post-translational O-linked β-N acetylglucosamine (O-GlcNAc) modification acts as a nutrient-sensing mechanism. Here the authors report that O-GlcNAc transferase inhibits adipose tissue lipolysis via O-GlcNAcylation of the lipid droplet protein perilipin 1 and thus promotes diet-induced obesity.Yunfan YangMinnie FuMin-Dian LiKaisi ZhangBichen ZhangSimeng WangYuyang LiuWeiming NiQunxiang OngJia MiXiaoyong YangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yunfan Yang Minnie Fu Min-Dian Li Kaisi Zhang Bichen Zhang Simeng Wang Yuyang Liu Weiming Ni Qunxiang Ong Jia Mi Xiaoyong Yang O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity
description	Post-translational O-linked β-N acetylglucosamine (O-GlcNAc) modification acts as a nutrient-sensing mechanism. Here the authors report that O-GlcNAc transferase inhibits adipose tissue lipolysis via O-GlcNAcylation of the lipid droplet protein perilipin 1 and thus promotes diet-induced obesity.
format	article
author	Yunfan Yang Minnie Fu Min-Dian Li Kaisi Zhang Bichen Zhang Simeng Wang Yuyang Liu Weiming Ni Qunxiang Ong Jia Mi Xiaoyong Yang
author_facet	Yunfan Yang Minnie Fu Min-Dian Li Kaisi Zhang Bichen Zhang Simeng Wang Yuyang Liu Weiming Ni Qunxiang Ong Jia Mi Xiaoyong Yang
author_sort	Yunfan Yang
title	O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity
title_short	O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity
title_full	O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity
title_fullStr	O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity
title_full_unstemmed	O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity
title_sort	o-glcnac transferase inhibits visceral fat lipolysis and promotes diet-induced obesity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/02a0ca40f2d6493cae075a4260c04f9c
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O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity

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