ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma

Thyroid carcinoma is one of the most common endocrine malignancies, in which papillary thyroid carcinoma (PTC) is the main pathotype. ANXA1 plays a significant role in many cancer types, but how it works in PTC has not been identified. MYC is a common transcript factor involved in tumorigenesis, dev...

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Autores principales:	Xiaomei Ying, Liang Chen, Jiaheng Xie, Yiming Hu, Qingqing Wu, Liyu Cao, Hongzhu Yu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	anxa1 myc pan-cancer ptc immune infiltration gsea Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/02a32fe8920b43988130deb688c57aca
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spelling	oai:doaj.org-article:02a32fe8920b43988130deb688c57aca2021-11-04T15:51:54ZANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma2165-59792165-598710.1080/21655979.2021.1996511https://doaj.org/article/02a32fe8920b43988130deb688c57aca2021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1996511https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Thyroid carcinoma is one of the most common endocrine malignancies, in which papillary thyroid carcinoma (PTC) is the main pathotype. ANXA1 plays a significant role in many cancer types, but how it works in PTC has not been identified. MYC is a common transcript factor involved in tumorigenesis, development, invasion, and metastasis. The relation between ANXA1 and MYC has not been proved in PTC. In this study, firstly, we analyzed the expression and prognostic value of ANXA1 in pan-cancer using the data from the UCSC database. Then we explore the role of ANXA1 in PTC, including expression, prognostic value, and immune infiltration. In addition, we evaluated the relation between ANXA1 and the transcription factor MYC. Finally, we identified the expression of ANXA1 and MYC and then evaluated their function associated with proliferation and apoptosis in PTC cell lines by CCK8 proliferation and flow cytometry apoptosis experiment. We found that ANXA1 is up-regulated in PTC comparing with normal patients. High expression of ANXA1 was associated with adverse overall survival of PTC. ANXA1 may be regulated by MYC to promote the proliferation of PTC. MYC may regulate the expression of ANXA and thus affect the proliferation of PTC.Xiaomei YingLiang ChenJiaheng XieYiming HuQingqing WuLiyu CaoHongzhu YuTaylor & Francis Grouparticleanxa1mycpan-cancerptcimmune infiltrationgseaBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anxa1 myc pan-cancer ptc immune infiltration gsea Biotechnology TP248.13-248.65
spellingShingle	anxa1 myc pan-cancer ptc immune infiltration gsea Biotechnology TP248.13-248.65 Xiaomei Ying Liang Chen Jiaheng Xie Yiming Hu Qingqing Wu Liyu Cao Hongzhu Yu ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma
description	Thyroid carcinoma is one of the most common endocrine malignancies, in which papillary thyroid carcinoma (PTC) is the main pathotype. ANXA1 plays a significant role in many cancer types, but how it works in PTC has not been identified. MYC is a common transcript factor involved in tumorigenesis, development, invasion, and metastasis. The relation between ANXA1 and MYC has not been proved in PTC. In this study, firstly, we analyzed the expression and prognostic value of ANXA1 in pan-cancer using the data from the UCSC database. Then we explore the role of ANXA1 in PTC, including expression, prognostic value, and immune infiltration. In addition, we evaluated the relation between ANXA1 and the transcription factor MYC. Finally, we identified the expression of ANXA1 and MYC and then evaluated their function associated with proliferation and apoptosis in PTC cell lines by CCK8 proliferation and flow cytometry apoptosis experiment. We found that ANXA1 is up-regulated in PTC comparing with normal patients. High expression of ANXA1 was associated with adverse overall survival of PTC. ANXA1 may be regulated by MYC to promote the proliferation of PTC. MYC may regulate the expression of ANXA and thus affect the proliferation of PTC.
format	article
author	Xiaomei Ying Liang Chen Jiaheng Xie Yiming Hu Qingqing Wu Liyu Cao Hongzhu Yu
author_facet	Xiaomei Ying Liang Chen Jiaheng Xie Yiming Hu Qingqing Wu Liyu Cao Hongzhu Yu
author_sort	Xiaomei Ying
title	ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma
title_short	ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma
title_full	ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma
title_fullStr	ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma
title_full_unstemmed	ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma
title_sort	anxa1 (annexin a1) regulated by myc (myc proto-oncogene) promotes the growth of papillary thyroid carcinoma
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/02a32fe8920b43988130deb688c57aca
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ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma

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