Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer

Radionuclides that emit alpha particles (charged helium nuclei) are currently used clinically to treat cancers including prostate cancer. Here, the authors combine a humanized antibody to an alpha particle emitter, specifically to target a downstream effector of the androgen receptor and create a fe...

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Autores principales:	Michael R. McDevitt, Daniel L. J. Thorek, Takeshi Hashimoto, Tatsuo Gondo, Darren R. Veach, Sai Kiran Sharma, Teja Muralidhar Kalidindi, Diane S. Abou, Philip A. Watson, Bradley J. Beattie, Oskar Vilhemsson Timmermand, Sven-Erik Strand, Jason S. Lewis, Peter T. Scardino, Howard I. Scher, Hans Lilja, Steven M. Larson, David Ulmert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/02a356c6cc14425c8da1a1e7764743bc
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spelling	oai:doaj.org-article:02a356c6cc14425c8da1a1e7764743bc2021-12-02T16:50:08ZFeed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer10.1038/s41467-018-04107-w2041-1723https://doaj.org/article/02a356c6cc14425c8da1a1e7764743bc2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04107-whttps://doaj.org/toc/2041-1723Radionuclides that emit alpha particles (charged helium nuclei) are currently used clinically to treat cancers including prostate cancer. Here, the authors combine a humanized antibody to an alpha particle emitter, specifically to target a downstream effector of the androgen receptor and create a feed forward loop that increases the therapeutic efficacy.Michael R. McDevittDaniel L. J. ThorekTakeshi HashimotoTatsuo GondoDarren R. VeachSai Kiran SharmaTeja Muralidhar KalidindiDiane S. AbouPhilip A. WatsonBradley J. BeattieOskar Vilhemsson TimmermandSven-Erik StrandJason S. LewisPeter T. ScardinoHoward I. ScherHans LiljaSteven M. LarsonDavid UlmertNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael R. McDevitt Daniel L. J. Thorek Takeshi Hashimoto Tatsuo Gondo Darren R. Veach Sai Kiran Sharma Teja Muralidhar Kalidindi Diane S. Abou Philip A. Watson Bradley J. Beattie Oskar Vilhemsson Timmermand Sven-Erik Strand Jason S. Lewis Peter T. Scardino Howard I. Scher Hans Lilja Steven M. Larson David Ulmert Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer
description	Radionuclides that emit alpha particles (charged helium nuclei) are currently used clinically to treat cancers including prostate cancer. Here, the authors combine a humanized antibody to an alpha particle emitter, specifically to target a downstream effector of the androgen receptor and create a feed forward loop that increases the therapeutic efficacy.
format	article
author	Michael R. McDevitt Daniel L. J. Thorek Takeshi Hashimoto Tatsuo Gondo Darren R. Veach Sai Kiran Sharma Teja Muralidhar Kalidindi Diane S. Abou Philip A. Watson Bradley J. Beattie Oskar Vilhemsson Timmermand Sven-Erik Strand Jason S. Lewis Peter T. Scardino Howard I. Scher Hans Lilja Steven M. Larson David Ulmert
author_facet	Michael R. McDevitt Daniel L. J. Thorek Takeshi Hashimoto Tatsuo Gondo Darren R. Veach Sai Kiran Sharma Teja Muralidhar Kalidindi Diane S. Abou Philip A. Watson Bradley J. Beattie Oskar Vilhemsson Timmermand Sven-Erik Strand Jason S. Lewis Peter T. Scardino Howard I. Scher Hans Lilja Steven M. Larson David Ulmert
author_sort	Michael R. McDevitt
title	Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer
title_short	Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer
title_full	Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer
title_fullStr	Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer
title_full_unstemmed	Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer
title_sort	feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/02a356c6cc14425c8da1a1e7764743bc
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Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer

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