Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer

Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer

The heterogeneity of tumor evolution from AR-positive, adenocarcinoma to AR-negative, neuroendocrine prostate cancer (NEPC) is not fully characterized. Here the authors generate a mouse model to show that Rb1 loss and MYCN overexpression accelerates the progression to AR-negative NEPC and identify e...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Nicholas J. Brady, Alyssa M. Bagadion, Richa Singh, Vincenza Conteduca, Lucie Van Emmenis, Elisa Arceci, Hubert Pakula, Ryan Carelli, Francesca Khani, Martin Bakht, Michael Sigouros, Rohan Bareja, Andrea Sboner, Olivier Elemento, Scott Tagawa, David M. Nanus, Massimo Loda, Himisha Beltran, Brian Robinson, David S. Rickman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/02a3612e2f2a462990758033d59bb602
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:The heterogeneity of tumor evolution from AR-positive, adenocarcinoma to AR-negative, neuroendocrine prostate cancer (NEPC) is not fully characterized. Here the authors generate a mouse model to show that Rb1 loss and MYCN overexpression accelerates the progression to AR-negative NEPC and identify emergence of distinct subpopulations of NEPC cells.

Ejemplares similares