Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer

The heterogeneity of tumor evolution from AR-positive, adenocarcinoma to AR-negative, neuroendocrine prostate cancer (NEPC) is not fully characterized. Here the authors generate a mouse model to show that Rb1 loss and MYCN overexpression accelerates the progression to AR-negative NEPC and identify e...

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Autores principales:	Nicholas J. Brady, Alyssa M. Bagadion, Richa Singh, Vincenza Conteduca, Lucie Van Emmenis, Elisa Arceci, Hubert Pakula, Ryan Carelli, Francesca Khani, Martin Bakht, Michael Sigouros, Rohan Bareja, Andrea Sboner, Olivier Elemento, Scott Tagawa, David M. Nanus, Massimo Loda, Himisha Beltran, Brian Robinson, David S. Rickman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/02a3612e2f2a462990758033d59bb602
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spelling	oai:doaj.org-article:02a3612e2f2a462990758033d59bb6022021-12-02T17:52:24ZTemporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer10.1038/s41467-021-23780-y2041-1723https://doaj.org/article/02a3612e2f2a462990758033d59bb6022021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23780-yhttps://doaj.org/toc/2041-1723The heterogeneity of tumor evolution from AR-positive, adenocarcinoma to AR-negative, neuroendocrine prostate cancer (NEPC) is not fully characterized. Here the authors generate a mouse model to show that Rb1 loss and MYCN overexpression accelerates the progression to AR-negative NEPC and identify emergence of distinct subpopulations of NEPC cells.Nicholas J. BradyAlyssa M. BagadionRicha SinghVincenza ConteducaLucie Van EmmenisElisa ArceciHubert PakulaRyan CarelliFrancesca KhaniMartin BakhtMichael SigourosRohan BarejaAndrea SbonerOlivier ElementoScott TagawaDavid M. NanusMassimo LodaHimisha BeltranBrian RobinsonDavid S. RickmanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas J. Brady Alyssa M. Bagadion Richa Singh Vincenza Conteduca Lucie Van Emmenis Elisa Arceci Hubert Pakula Ryan Carelli Francesca Khani Martin Bakht Michael Sigouros Rohan Bareja Andrea Sboner Olivier Elemento Scott Tagawa David M. Nanus Massimo Loda Himisha Beltran Brian Robinson David S. Rickman Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer
description	The heterogeneity of tumor evolution from AR-positive, adenocarcinoma to AR-negative, neuroendocrine prostate cancer (NEPC) is not fully characterized. Here the authors generate a mouse model to show that Rb1 loss and MYCN overexpression accelerates the progression to AR-negative NEPC and identify emergence of distinct subpopulations of NEPC cells.
format	article
author	Nicholas J. Brady Alyssa M. Bagadion Richa Singh Vincenza Conteduca Lucie Van Emmenis Elisa Arceci Hubert Pakula Ryan Carelli Francesca Khani Martin Bakht Michael Sigouros Rohan Bareja Andrea Sboner Olivier Elemento Scott Tagawa David M. Nanus Massimo Loda Himisha Beltran Brian Robinson David S. Rickman
author_facet	Nicholas J. Brady Alyssa M. Bagadion Richa Singh Vincenza Conteduca Lucie Van Emmenis Elisa Arceci Hubert Pakula Ryan Carelli Francesca Khani Martin Bakht Michael Sigouros Rohan Bareja Andrea Sboner Olivier Elemento Scott Tagawa David M. Nanus Massimo Loda Himisha Beltran Brian Robinson David S. Rickman
author_sort	Nicholas J. Brady
title	Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer
title_short	Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer
title_full	Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer
title_fullStr	Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer
title_full_unstemmed	Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer
title_sort	temporal evolution of cellular heterogeneity during the progression to advanced ar-negative prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/02a3612e2f2a462990758033d59bb602
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Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer

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