Adequate tissue sampling for the assessment of pathological tumor regression in pancreatic cancer

Abstract Standardized pathological evaluation of the regression assessment of neoadjuvant pancreatic cancer is necessary to improve prognostication and compare treatment outcomes in clinical trials. However, appropriate tissue sampling from surgically resected pancreatic cancer after neoadjuvant the...

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Autores principales:	Masanao Yokohira, Minoru Oshima, Keiko Yamakawa, Juanjuan Ye, Yuko Nakano-Narusawa, Reiji Haba, Yuki Fukumura, Kenichi Hirabayashi, Hiroshi Yamaguchi, Motohiro Kojima, Keiichi Okano, Yasuyuki Suzuki, Yoko Matsuda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/02a40941f95648ac932c3075aa48d32a
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spelling	oai:doaj.org-article:02a40941f95648ac932c3075aa48d32a2021-12-02T17:04:07ZAdequate tissue sampling for the assessment of pathological tumor regression in pancreatic cancer10.1038/s41598-021-86152-y2045-2322https://doaj.org/article/02a40941f95648ac932c3075aa48d32a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86152-yhttps://doaj.org/toc/2045-2322Abstract Standardized pathological evaluation of the regression assessment of neoadjuvant pancreatic cancer is necessary to improve prognostication and compare treatment outcomes in clinical trials. However, appropriate tissue sampling from surgically resected pancreatic cancer after neoadjuvant therapy has not been elucidated. We compared the tumor regression scores in the largest cancer slide determined macroscopically or histologically. We reviewed all slides and macroscopic photos of cut surfaces from resected pancreas of patients treated with neoadjuvant chemotherapy (n = 137; chemoradiotherapy or chemotherapy). The tumor regression scores (the Evans, College of American Pathologists, Japanese Pancreas Society grading systems, and Area of Residual Tumor [ART] score) were evaluated for the largest tumor slide determined by macroscopy or histologically as well as all slides from the resected pancreas. The largest cancer slides determined macroscopically and histologically were discrepant in 26% of the cases. Cancer cells were not detected in the largest macroscopically defined cut slides in 3%. Only ART scores assessed in the largest histological slides displayed significant difference in overall survival. We recommend obtaining the largest histological slides to provide adequate assessment for regression of neoadjuvant-treated pancreatic cancer. Sufficient sampling to detect the largest histological slides would be mandatory.Masanao YokohiraMinoru OshimaKeiko YamakawaJuanjuan YeYuko Nakano-NarusawaReiji HabaYuki FukumuraKenichi HirabayashiHiroshi YamaguchiMotohiro KojimaKeiichi OkanoYasuyuki SuzukiYoko MatsudaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masanao Yokohira Minoru Oshima Keiko Yamakawa Juanjuan Ye Yuko Nakano-Narusawa Reiji Haba Yuki Fukumura Kenichi Hirabayashi Hiroshi Yamaguchi Motohiro Kojima Keiichi Okano Yasuyuki Suzuki Yoko Matsuda Adequate tissue sampling for the assessment of pathological tumor regression in pancreatic cancer
description	Abstract Standardized pathological evaluation of the regression assessment of neoadjuvant pancreatic cancer is necessary to improve prognostication and compare treatment outcomes in clinical trials. However, appropriate tissue sampling from surgically resected pancreatic cancer after neoadjuvant therapy has not been elucidated. We compared the tumor regression scores in the largest cancer slide determined macroscopically or histologically. We reviewed all slides and macroscopic photos of cut surfaces from resected pancreas of patients treated with neoadjuvant chemotherapy (n = 137; chemoradiotherapy or chemotherapy). The tumor regression scores (the Evans, College of American Pathologists, Japanese Pancreas Society grading systems, and Area of Residual Tumor [ART] score) were evaluated for the largest tumor slide determined by macroscopy or histologically as well as all slides from the resected pancreas. The largest cancer slides determined macroscopically and histologically were discrepant in 26% of the cases. Cancer cells were not detected in the largest macroscopically defined cut slides in 3%. Only ART scores assessed in the largest histological slides displayed significant difference in overall survival. We recommend obtaining the largest histological slides to provide adequate assessment for regression of neoadjuvant-treated pancreatic cancer. Sufficient sampling to detect the largest histological slides would be mandatory.
format	article
author	Masanao Yokohira Minoru Oshima Keiko Yamakawa Juanjuan Ye Yuko Nakano-Narusawa Reiji Haba Yuki Fukumura Kenichi Hirabayashi Hiroshi Yamaguchi Motohiro Kojima Keiichi Okano Yasuyuki Suzuki Yoko Matsuda
author_facet	Masanao Yokohira Minoru Oshima Keiko Yamakawa Juanjuan Ye Yuko Nakano-Narusawa Reiji Haba Yuki Fukumura Kenichi Hirabayashi Hiroshi Yamaguchi Motohiro Kojima Keiichi Okano Yasuyuki Suzuki Yoko Matsuda
author_sort	Masanao Yokohira
title	Adequate tissue sampling for the assessment of pathological tumor regression in pancreatic cancer
title_short	Adequate tissue sampling for the assessment of pathological tumor regression in pancreatic cancer
title_full	Adequate tissue sampling for the assessment of pathological tumor regression in pancreatic cancer
title_fullStr	Adequate tissue sampling for the assessment of pathological tumor regression in pancreatic cancer
title_full_unstemmed	Adequate tissue sampling for the assessment of pathological tumor regression in pancreatic cancer
title_sort	adequate tissue sampling for the assessment of pathological tumor regression in pancreatic cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/02a40941f95648ac932c3075aa48d32a
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Adequate tissue sampling for the assessment of pathological tumor regression in pancreatic cancer

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