Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study

Objectives: To compare the application value of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) in breast galactography. Materials and Methods: A total of 128 patients with pathological nipple discharge (PND) were selected to undergo galactography. DBT and FFDM were perf...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Juan Tao, Hao Liao, Yuan Liu, Qingsong Peng, Wenying Zhu, Shuyi Peng, Jie Liu, Leqing Chen, Fan Yang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	digital breast tomosynthesis galactography pathological nipple discharge full-field digital mammography average glandular dose Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/02a7e40e65124b10862787fb2b1b6b66
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:02a7e40e65124b10862787fb2b1b6b66
record_format	dspace
spelling	oai:doaj.org-article:02a7e40e65124b10862787fb2b1b6b662021-11-25T17:21:15ZEvaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study10.3390/diagnostics111120602075-4418https://doaj.org/article/02a7e40e65124b10862787fb2b1b6b662021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2060https://doaj.org/toc/2075-4418Objectives: To compare the application value of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) in breast galactography. Materials and Methods: A total of 128 patients with pathological nipple discharge (PND) were selected to undergo galactography. DBT and FFDM were performed for each patient after injecting the contrast agent; the radiation dose of DBT and FFDM was calculated, and the image quality was evaluated in consensus by two senior breast radiologists. Histopathologic data were found in 49 of the 128 patients. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for both FFDM- and DBT-galactography were calculated using histopathologic results as a reference standard. Data were presented as percentages along with their 95% confidence intervals (CI). Results: The average age of the 128 patients was 46.53 years. The average glandular dose (AGD) of DBT-galactography was slightly higher than that of FFDM-galactography (<i>p</i> < 0.001). DBT-galactography was 30.7% higher than FFDM-galactography in CC view, while DBT-galactography increased by 21.7% compared with FFDM-galactography in ML view. Regarding catheter anatomic distortion, structure detail, and overall image quality groups, DBT scores were higher than FFDM scores, and the differences were significant for all measures (<i>p</i> < 0.05). In 49 patients with pathological nipple discharge, we found that the DBT-galactography had higher sensitivity, specificity, PPV, and NPV (93.3%, 75%, 97.7%, and 50%, respectively) than FFDM-galactography (91.1%, 50%, 95.3%, and 33.3%, respectively). Conclusions: Compared to FFDM-galactography, within the acceptable radiation dose range, DBT-galactography increases the sensitivity and specificity of lesion detection by improving the image quality, providing more confidence for the diagnosis of clinical ductal lesions.Juan TaoHao LiaoYuan LiuQingsong PengWenying ZhuShuyi PengJie LiuLeqing ChenFan YangMDPI AGarticledigital breast tomosynthesisgalactographypathological nipple dischargefull-field digital mammographyaverage glandular doseMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2060, p 2060 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	digital breast tomosynthesis galactography pathological nipple discharge full-field digital mammography average glandular dose Medicine (General) R5-920
spellingShingle	digital breast tomosynthesis galactography pathological nipple discharge full-field digital mammography average glandular dose Medicine (General) R5-920 Juan Tao Hao Liao Yuan Liu Qingsong Peng Wenying Zhu Shuyi Peng Jie Liu Leqing Chen Fan Yang Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study
description	Objectives: To compare the application value of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) in breast galactography. Materials and Methods: A total of 128 patients with pathological nipple discharge (PND) were selected to undergo galactography. DBT and FFDM were performed for each patient after injecting the contrast agent; the radiation dose of DBT and FFDM was calculated, and the image quality was evaluated in consensus by two senior breast radiologists. Histopathologic data were found in 49 of the 128 patients. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for both FFDM- and DBT-galactography were calculated using histopathologic results as a reference standard. Data were presented as percentages along with their 95% confidence intervals (CI). Results: The average age of the 128 patients was 46.53 years. The average glandular dose (AGD) of DBT-galactography was slightly higher than that of FFDM-galactography (<i>p</i> < 0.001). DBT-galactography was 30.7% higher than FFDM-galactography in CC view, while DBT-galactography increased by 21.7% compared with FFDM-galactography in ML view. Regarding catheter anatomic distortion, structure detail, and overall image quality groups, DBT scores were higher than FFDM scores, and the differences were significant for all measures (<i>p</i> < 0.05). In 49 patients with pathological nipple discharge, we found that the DBT-galactography had higher sensitivity, specificity, PPV, and NPV (93.3%, 75%, 97.7%, and 50%, respectively) than FFDM-galactography (91.1%, 50%, 95.3%, and 33.3%, respectively). Conclusions: Compared to FFDM-galactography, within the acceptable radiation dose range, DBT-galactography increases the sensitivity and specificity of lesion detection by improving the image quality, providing more confidence for the diagnosis of clinical ductal lesions.
format	article
author	Juan Tao Hao Liao Yuan Liu Qingsong Peng Wenying Zhu Shuyi Peng Jie Liu Leqing Chen Fan Yang
author_facet	Juan Tao Hao Liao Yuan Liu Qingsong Peng Wenying Zhu Shuyi Peng Jie Liu Leqing Chen Fan Yang
author_sort	Juan Tao
title	Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study
title_short	Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study
title_full	Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study
title_fullStr	Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study
title_full_unstemmed	Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study
title_sort	evaluation of breast galactography using digital breast tomosynthesis: a clinical exploratory study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/02a7e40e65124b10862787fb2b1b6b66
work_keys_str_mv	AT juantao evaluationofbreastgalactographyusingdigitalbreasttomosynthesisaclinicalexploratorystudy AT haoliao evaluationofbreastgalactographyusingdigitalbreasttomosynthesisaclinicalexploratorystudy AT yuanliu evaluationofbreastgalactographyusingdigitalbreasttomosynthesisaclinicalexploratorystudy AT qingsongpeng evaluationofbreastgalactographyusingdigitalbreasttomosynthesisaclinicalexploratorystudy AT wenyingzhu evaluationofbreastgalactographyusingdigitalbreasttomosynthesisaclinicalexploratorystudy AT shuyipeng evaluationofbreastgalactographyusingdigitalbreasttomosynthesisaclinicalexploratorystudy AT jieliu evaluationofbreastgalactographyusingdigitalbreasttomosynthesisaclinicalexploratorystudy AT leqingchen evaluationofbreastgalactographyusingdigitalbreasttomosynthesisaclinicalexploratorystudy AT fanyang evaluationofbreastgalactographyusingdigitalbreasttomosynthesisaclinicalexploratorystudy
_version_	1718412448890880000

Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study

Ejemplares similares