Correlation between arterial wall stiffness, N-terminal prohormone of brain natriuretic peptide, functional and structural myocardial abnormalities in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy

Aim. To assess arterial wall stiffness, plasma levels of of N-terminal prohormone of brain natriuretic peptide (NT-proBNP), as well as functional state and structure of the myocardium in patients with type 2 diabetes mellitus (T2DM) and cardiac autonomic neuropathy (CAN). Materials and Methods. Th...

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Autores principales:	Viktoriya Alexandrovna Serhiyenko, Alexander Alexandrovich Serhiyenko, Boris Nikitich Mankovsky
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2013
Materias:	type 2 diabetes mellitus cardiac autonomic neuropathy arterial wall stiffness brain natriuretic peptide myocardium Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/02a93fa5751f468f93b2ad34b4a125ac
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spelling	oai:doaj.org-article:02a93fa5751f468f93b2ad34b4a125ac2021-11-14T09:00:18ZCorrelation between arterial wall stiffness, N-terminal prohormone of brain natriuretic peptide, functional and structural myocardial abnormalities in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy2072-03512072-037810.14341/DM2013472-77https://doaj.org/article/02a93fa5751f468f93b2ad34b4a125ac2013-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6277https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To assess arterial wall stiffness, plasma levels of of N-terminal prohormone of brain natriuretic peptide (NT-proBNP), as well as functional state and structure of the myocardium in patients with type 2 diabetes mellitus (T2DM) and cardiac autonomic neuropathy (CAN). Materials and Methods. The study involved a total of 65 patients with T2DM. 12 had no evidence of cardiovascular disease (CVD) or CAN, 14 were diagnosed with subclinical stage of CAN, 18 ? with functional stage, and 21 ? with organic stage. We measured aortic pulse wave velocity (PWV), aortic augmentation index (AIx), brachial artery AIx, ambulatory arterial stiffness index (AASI) and plasma levels of NT-proBNP. Clinical examination included ECG, Holter monitoring, ambulatory BP measurement and echocardiography. Results. Patients with isolated T2DM showed a trend for increased vascular wall stiffness. PWV was increased in patients with subclinical stage of CAN. Aortic and brachial AIx, PWV and AASI were elevated in patients with functional stage of CAN, PWV being significantly higher vs. subclinical CAN subgroup. Organic stage was characterized by pathologically increased values of all primary parameters; PWV and AASI were significantly higher compared with other groups. Development and progression of CAN was accompanied by an increase in NT-proBNP plasma levels. Concentration of NT-proBNP was in direct correlation with left ventricular mass (LVM) and PWV. PWV and LVM values also directly correlated between themselves. Conclusion. Development and progression of CAN in patients with T2DM is accompanied by an increase in vascular wall stiffness. The elevation of plasma NT-proBNP in patients with T2DM correlates with the development of CAN and is significantly and independently associated with an increase in LVM and PWV. Our data suggests the pathophysiological interconnection between metabolic, functional and structural myocardial abnormalities in patients with T2DM and CAN.Viktoriya Alexandrovna SerhiyenkoAlexander Alexandrovich SerhiyenkoBoris Nikitich MankovskyEndocrinology Research Centrearticletype 2 diabetes mellituscardiac autonomic neuropathyarterial wall stiffnessbrain natriuretic peptidemyocardiumNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 4, Pp 72-77 (2013)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus cardiac autonomic neuropathy arterial wall stiffness brain natriuretic peptide myocardium Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus cardiac autonomic neuropathy arterial wall stiffness brain natriuretic peptide myocardium Nutritional diseases. Deficiency diseases RC620-627 Viktoriya Alexandrovna Serhiyenko Alexander Alexandrovich Serhiyenko Boris Nikitich Mankovsky Correlation between arterial wall stiffness, N-terminal prohormone of brain natriuretic peptide, functional and structural myocardial abnormalities in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy
description	Aim. To assess arterial wall stiffness, plasma levels of of N-terminal prohormone of brain natriuretic peptide (NT-proBNP), as well as functional state and structure of the myocardium in patients with type 2 diabetes mellitus (T2DM) and cardiac autonomic neuropathy (CAN). Materials and Methods. The study involved a total of 65 patients with T2DM. 12 had no evidence of cardiovascular disease (CVD) or CAN, 14 were diagnosed with subclinical stage of CAN, 18 ? with functional stage, and 21 ? with organic stage. We measured aortic pulse wave velocity (PWV), aortic augmentation index (AIx), brachial artery AIx, ambulatory arterial stiffness index (AASI) and plasma levels of NT-proBNP. Clinical examination included ECG, Holter monitoring, ambulatory BP measurement and echocardiography. Results. Patients with isolated T2DM showed a trend for increased vascular wall stiffness. PWV was increased in patients with subclinical stage of CAN. Aortic and brachial AIx, PWV and AASI were elevated in patients with functional stage of CAN, PWV being significantly higher vs. subclinical CAN subgroup. Organic stage was characterized by pathologically increased values of all primary parameters; PWV and AASI were significantly higher compared with other groups. Development and progression of CAN was accompanied by an increase in NT-proBNP plasma levels. Concentration of NT-proBNP was in direct correlation with left ventricular mass (LVM) and PWV. PWV and LVM values also directly correlated between themselves. Conclusion. Development and progression of CAN in patients with T2DM is accompanied by an increase in vascular wall stiffness. The elevation of plasma NT-proBNP in patients with T2DM correlates with the development of CAN and is significantly and independently associated with an increase in LVM and PWV. Our data suggests the pathophysiological interconnection between metabolic, functional and structural myocardial abnormalities in patients with T2DM and CAN.
format	article
author	Viktoriya Alexandrovna Serhiyenko Alexander Alexandrovich Serhiyenko Boris Nikitich Mankovsky
author_facet	Viktoriya Alexandrovna Serhiyenko Alexander Alexandrovich Serhiyenko Boris Nikitich Mankovsky
author_sort	Viktoriya Alexandrovna Serhiyenko
title	Correlation between arterial wall stiffness, N-terminal prohormone of brain natriuretic peptide, functional and structural myocardial abnormalities in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy
title_short	Correlation between arterial wall stiffness, N-terminal prohormone of brain natriuretic peptide, functional and structural myocardial abnormalities in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy
title_full	Correlation between arterial wall stiffness, N-terminal prohormone of brain natriuretic peptide, functional and structural myocardial abnormalities in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy
title_fullStr	Correlation between arterial wall stiffness, N-terminal prohormone of brain natriuretic peptide, functional and structural myocardial abnormalities in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy
title_full_unstemmed	Correlation between arterial wall stiffness, N-terminal prohormone of brain natriuretic peptide, functional and structural myocardial abnormalities in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy
title_sort	correlation between arterial wall stiffness, n-terminal prohormone of brain natriuretic peptide, functional and structural myocardial abnormalities in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy
publisher	Endocrinology Research Centre
publishDate	2013
url	https://doaj.org/article/02a93fa5751f468f93b2ad34b4a125ac
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Correlation between arterial wall stiffness, N-terminal prohormone of brain natriuretic peptide, functional and structural myocardial abnormalities in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy

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