A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response

Mammalian glycans have a role in host immunity but little is known about how they activate the host response in the context of autoimmune diseases. Here, the authors identify Manβ1-4GlcNAc as a novel innate immune modulator associated with chronic autoimmune diseases.

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Autores principales:	Charles S. Fermaintt, Kanae Sano, Zhida Liu, Nozomi Ishii, Junichi Seino, Nicole Dobbs, Tadashi Suzuki, Yang-Xin Fu, Mark A. Lehrman, Ichiro Matsuo, Nan Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/02aa3410ad05460ab0fc4008becd936e
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spelling	oai:doaj.org-article:02aa3410ad05460ab0fc4008becd936e2021-12-02T14:38:45ZA bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response10.1038/s41467-019-10319-52041-1723https://doaj.org/article/02aa3410ad05460ab0fc4008becd936e2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10319-5https://doaj.org/toc/2041-1723Mammalian glycans have a role in host immunity but little is known about how they activate the host response in the context of autoimmune diseases. Here, the authors identify Manβ1-4GlcNAc as a novel innate immune modulator associated with chronic autoimmune diseases.Charles S. FermainttKanae SanoZhida LiuNozomi IshiiJunichi SeinoNicole DobbsTadashi SuzukiYang-Xin FuMark A. LehrmanIchiro MatsuoNan YanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Charles S. Fermaintt Kanae Sano Zhida Liu Nozomi Ishii Junichi Seino Nicole Dobbs Tadashi Suzuki Yang-Xin Fu Mark A. Lehrman Ichiro Matsuo Nan Yan A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response
description	Mammalian glycans have a role in host immunity but little is known about how they activate the host response in the context of autoimmune diseases. Here, the authors identify Manβ1-4GlcNAc as a novel innate immune modulator associated with chronic autoimmune diseases.
format	article
author	Charles S. Fermaintt Kanae Sano Zhida Liu Nozomi Ishii Junichi Seino Nicole Dobbs Tadashi Suzuki Yang-Xin Fu Mark A. Lehrman Ichiro Matsuo Nan Yan
author_facet	Charles S. Fermaintt Kanae Sano Zhida Liu Nozomi Ishii Junichi Seino Nicole Dobbs Tadashi Suzuki Yang-Xin Fu Mark A. Lehrman Ichiro Matsuo Nan Yan
author_sort	Charles S. Fermaintt
title	A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response
title_short	A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response
title_full	A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response
title_fullStr	A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response
title_full_unstemmed	A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response
title_sort	bioactive mammalian disaccharide associated with autoimmunity activates sting-tbk1-dependent immune response
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/02aa3410ad05460ab0fc4008becd936e
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A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response

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