Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Peripheral Mononuclear Cells in Patients With Ankylosing Spondylitis

Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Peripheral Mononuclear Cells in Patients With Ankylosing Spondylitis

ObjectiveGenetic studies on ankylosing spondylitis (AS) have identified more than 100 pathogenic genes. Building a bridge between these genes and biologically targeted therapies is the current research hotspot.MethodsWe integrated single-cell assaying transposase-accessible chromatin sequencing (scA...

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Autores principales: Huixuan Xu, Haiyan Yu, Lixiong Liu, Hongwei Wu, Cantong Zhang, Wanxia Cai, Xiaoping Hong, Dongzhou Liu, Donge Tang, Yong Dai
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
ankylosing spondylitis
single-cell RNA sequencing
single-cell assaying transposase accessible chromatin sequencing
NFkB
TNF signaling pathway
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/02b38754374c4765b29df074b937e432
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