Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

The gut microbiome is an important regulator of metabolic health. Here the authors show that intestinal bacteria metabolize dietary linoleic acid to 10-hydroxy-cis-12-octadecenoic acid (HYA) which confers host resistance to high fat diet-induced obesity in mice.

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Autores principales:	Junki Miyamoto, Miki Igarashi, Keita Watanabe, Shin-ichiro Karaki, Hiromi Mukouyama, Shigenobu Kishino, Xuan Li, Atsuhiko Ichimura, Junichiro Irie, Yukihiko Sugimoto, Tetsuya Mizutani, Tatsuya Sugawara, Takashi Miki, Jun Ogawa, Daniel J. Drucker, Makoto Arita, Hiroshi Itoh, Ikuo Kimura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/02b641191e8447a5869df691887199f7
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spelling	oai:doaj.org-article:02b641191e8447a5869df691887199f72021-12-02T17:02:18ZGut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids10.1038/s41467-019-11978-02041-1723https://doaj.org/article/02b641191e8447a5869df691887199f72019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11978-0https://doaj.org/toc/2041-1723The gut microbiome is an important regulator of metabolic health. Here the authors show that intestinal bacteria metabolize dietary linoleic acid to 10-hydroxy-cis-12-octadecenoic acid (HYA) which confers host resistance to high fat diet-induced obesity in mice.Junki MiyamotoMiki IgarashiKeita WatanabeShin-ichiro KarakiHiromi MukouyamaShigenobu KishinoXuan LiAtsuhiko IchimuraJunichiro IrieYukihiko SugimotoTetsuya MizutaniTatsuya SugawaraTakashi MikiJun OgawaDaniel J. DruckerMakoto AritaHiroshi ItohIkuo KimuraNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junki Miyamoto Miki Igarashi Keita Watanabe Shin-ichiro Karaki Hiromi Mukouyama Shigenobu Kishino Xuan Li Atsuhiko Ichimura Junichiro Irie Yukihiko Sugimoto Tetsuya Mizutani Tatsuya Sugawara Takashi Miki Jun Ogawa Daniel J. Drucker Makoto Arita Hiroshi Itoh Ikuo Kimura Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids
description	The gut microbiome is an important regulator of metabolic health. Here the authors show that intestinal bacteria metabolize dietary linoleic acid to 10-hydroxy-cis-12-octadecenoic acid (HYA) which confers host resistance to high fat diet-induced obesity in mice.
format	article
author	Junki Miyamoto Miki Igarashi Keita Watanabe Shin-ichiro Karaki Hiromi Mukouyama Shigenobu Kishino Xuan Li Atsuhiko Ichimura Junichiro Irie Yukihiko Sugimoto Tetsuya Mizutani Tatsuya Sugawara Takashi Miki Jun Ogawa Daniel J. Drucker Makoto Arita Hiroshi Itoh Ikuo Kimura
author_facet	Junki Miyamoto Miki Igarashi Keita Watanabe Shin-ichiro Karaki Hiromi Mukouyama Shigenobu Kishino Xuan Li Atsuhiko Ichimura Junichiro Irie Yukihiko Sugimoto Tetsuya Mizutani Tatsuya Sugawara Takashi Miki Jun Ogawa Daniel J. Drucker Makoto Arita Hiroshi Itoh Ikuo Kimura
author_sort	Junki Miyamoto
title	Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids
title_short	Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids
title_full	Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids
title_fullStr	Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids
title_full_unstemmed	Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids
title_sort	gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/02b641191e8447a5869df691887199f7
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Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

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