Serum neurofilament light chain as a severity marker for spinocerebellar ataxia

Abstract Since the serum neurofilament light (NfL) chain is known as a promising biomarker in neurodegenerative diseases, we aimed to evaluate serum NfL as a biomarker indicating neuronal damage in autosomal-dominant (AD) spinocerebellar ataxia (SCA). We reviewed patients diagnosed with AD SCA in th...

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Autores principales: Hye-Rim Shin, Jangsup Moon, Woo-Jin Lee, Han Sang Lee, Eun Young Kim, Seoyi Shin, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Sang Kun Lee, Kon Chu
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/02b6e646b6a34ef78ff7d19e2ad5b1d3
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spelling oai:doaj.org-article:02b6e646b6a34ef78ff7d19e2ad5b1d32021-12-02T16:10:24ZSerum neurofilament light chain as a severity marker for spinocerebellar ataxia10.1038/s41598-021-92855-z2045-2322https://doaj.org/article/02b6e646b6a34ef78ff7d19e2ad5b1d32021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92855-zhttps://doaj.org/toc/2045-2322Abstract Since the serum neurofilament light (NfL) chain is known as a promising biomarker in neurodegenerative diseases, we aimed to evaluate serum NfL as a biomarker indicating neuronal damage in autosomal-dominant (AD) spinocerebellar ataxia (SCA). We reviewed patients diagnosed with AD SCA in the outpatient clinic of Seoul National University Hospital’s (SNUH) Department of Neurology between May and August of 2019. We reviewed the demographic data, clinical characteristics, Scale for the Assessment and Rating of Ataxia (SARA) score, and brain magnetic resonance imaging (MRI) scans. The serum NfL was measured by electrochemiluminescence (ECL) immunoassay. Forty-nine patients with AD SCA were reviewed and their serum NfL level was determined. The median serum NfL level (109.5 pg/mL) was higher than control (41.1 pg/mL) (p-value < 0.001). Among the AD SCA patients, there was a positive correlation between the serum NfL level and the trinucleotide repeat number (r = 0.47, p-value = 0.001), disease duration (r = 0.35, p-value = 0.019), disease duration/age × trinucleotide repeat number (r = 0.330, p-value = 0.021), and SARA score (n = 33; r = 0.37, p-value = 0.033). This study shows that serum NfL is elevated in AD SCA patients and correlates with clinical severity.Hye-Rim ShinJangsup MoonWoo-Jin LeeHan Sang LeeEun Young KimSeoyi ShinSoon-Tae LeeKeun-Hwa JungKyung-Il ParkKi-Young JungSang Kun LeeKon ChuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Hye-Rim Shin
Jangsup Moon
Woo-Jin Lee
Han Sang Lee
Eun Young Kim
Seoyi Shin
Soon-Tae Lee
Keun-Hwa Jung
Kyung-Il Park
Ki-Young Jung
Sang Kun Lee
Kon Chu
Serum neurofilament light chain as a severity marker for spinocerebellar ataxia
description Abstract Since the serum neurofilament light (NfL) chain is known as a promising biomarker in neurodegenerative diseases, we aimed to evaluate serum NfL as a biomarker indicating neuronal damage in autosomal-dominant (AD) spinocerebellar ataxia (SCA). We reviewed patients diagnosed with AD SCA in the outpatient clinic of Seoul National University Hospital’s (SNUH) Department of Neurology between May and August of 2019. We reviewed the demographic data, clinical characteristics, Scale for the Assessment and Rating of Ataxia (SARA) score, and brain magnetic resonance imaging (MRI) scans. The serum NfL was measured by electrochemiluminescence (ECL) immunoassay. Forty-nine patients with AD SCA were reviewed and their serum NfL level was determined. The median serum NfL level (109.5 pg/mL) was higher than control (41.1 pg/mL) (p-value < 0.001). Among the AD SCA patients, there was a positive correlation between the serum NfL level and the trinucleotide repeat number (r = 0.47, p-value = 0.001), disease duration (r = 0.35, p-value = 0.019), disease duration/age × trinucleotide repeat number (r = 0.330, p-value = 0.021), and SARA score (n = 33; r = 0.37, p-value = 0.033). This study shows that serum NfL is elevated in AD SCA patients and correlates with clinical severity.
format article
author Hye-Rim Shin
Jangsup Moon
Woo-Jin Lee
Han Sang Lee
Eun Young Kim
Seoyi Shin
Soon-Tae Lee
Keun-Hwa Jung
Kyung-Il Park
Ki-Young Jung
Sang Kun Lee
Kon Chu
author_facet Hye-Rim Shin
Jangsup Moon
Woo-Jin Lee
Han Sang Lee
Eun Young Kim
Seoyi Shin
Soon-Tae Lee
Keun-Hwa Jung
Kyung-Il Park
Ki-Young Jung
Sang Kun Lee
Kon Chu
author_sort Hye-Rim Shin
title Serum neurofilament light chain as a severity marker for spinocerebellar ataxia
title_short Serum neurofilament light chain as a severity marker for spinocerebellar ataxia
title_full Serum neurofilament light chain as a severity marker for spinocerebellar ataxia
title_fullStr Serum neurofilament light chain as a severity marker for spinocerebellar ataxia
title_full_unstemmed Serum neurofilament light chain as a severity marker for spinocerebellar ataxia
title_sort serum neurofilament light chain as a severity marker for spinocerebellar ataxia
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/02b6e646b6a34ef78ff7d19e2ad5b1d3
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