Sparse representation of sounds in the unanesthetized auditory cortex.

How do neuronal populations in the auditory cortex represent acoustic stimuli? Although sound-evoked neural responses in the anesthetized auditory cortex are mainly transient, recent experiments in the unanesthetized preparation have emphasized subpopulations with other response properties. To quant...

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Autores principales:	Tomás Hromádka, Michael R Deweese, Anthony M Zador
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/02b792a4736442309fcd601aba6e2afe
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spelling	oai:doaj.org-article:02b792a4736442309fcd601aba6e2afe2021-11-25T05:33:31ZSparse representation of sounds in the unanesthetized auditory cortex.1544-91731545-788510.1371/journal.pbio.0060016https://doaj.org/article/02b792a4736442309fcd601aba6e2afe2008-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18232737/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885How do neuronal populations in the auditory cortex represent acoustic stimuli? Although sound-evoked neural responses in the anesthetized auditory cortex are mainly transient, recent experiments in the unanesthetized preparation have emphasized subpopulations with other response properties. To quantify the relative contributions of these different subpopulations in the awake preparation, we have estimated the representation of sounds across the neuronal population using a representative ensemble of stimuli. We used cell-attached recording with a glass electrode, a method for which single-unit isolation does not depend on neuronal activity, to quantify the fraction of neurons engaged by acoustic stimuli (tones, frequency modulated sweeps, white-noise bursts, and natural stimuli) in the primary auditory cortex of awake head-fixed rats. We find that the population response is sparse, with stimuli typically eliciting high firing rates (>20 spikes/second) in less than 5% of neurons at any instant. Some neurons had very low spontaneous firing rates (<0.01 spikes/second). At the other extreme, some neurons had driven rates in excess of 50 spikes/second. Interestingly, the overall population response was well described by a lognormal distribution, rather than the exponential distribution that is often reported. Our results represent, to our knowledge, the first quantitative evidence for sparse representations of sounds in the unanesthetized auditory cortex. Our results are compatible with a model in which most neurons are silent much of the time, and in which representations are composed of small dynamic subsets of highly active neurons.Tomás HromádkaMichael R DeweeseAnthony M ZadorPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 6, Iss 1, p e16 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Tomás Hromádka Michael R Deweese Anthony M Zador Sparse representation of sounds in the unanesthetized auditory cortex.
description	How do neuronal populations in the auditory cortex represent acoustic stimuli? Although sound-evoked neural responses in the anesthetized auditory cortex are mainly transient, recent experiments in the unanesthetized preparation have emphasized subpopulations with other response properties. To quantify the relative contributions of these different subpopulations in the awake preparation, we have estimated the representation of sounds across the neuronal population using a representative ensemble of stimuli. We used cell-attached recording with a glass electrode, a method for which single-unit isolation does not depend on neuronal activity, to quantify the fraction of neurons engaged by acoustic stimuli (tones, frequency modulated sweeps, white-noise bursts, and natural stimuli) in the primary auditory cortex of awake head-fixed rats. We find that the population response is sparse, with stimuli typically eliciting high firing rates (>20 spikes/second) in less than 5% of neurons at any instant. Some neurons had very low spontaneous firing rates (<0.01 spikes/second). At the other extreme, some neurons had driven rates in excess of 50 spikes/second. Interestingly, the overall population response was well described by a lognormal distribution, rather than the exponential distribution that is often reported. Our results represent, to our knowledge, the first quantitative evidence for sparse representations of sounds in the unanesthetized auditory cortex. Our results are compatible with a model in which most neurons are silent much of the time, and in which representations are composed of small dynamic subsets of highly active neurons.
format	article
author	Tomás Hromádka Michael R Deweese Anthony M Zador
author_facet	Tomás Hromádka Michael R Deweese Anthony M Zador
author_sort	Tomás Hromádka
title	Sparse representation of sounds in the unanesthetized auditory cortex.
title_short	Sparse representation of sounds in the unanesthetized auditory cortex.
title_full	Sparse representation of sounds in the unanesthetized auditory cortex.
title_fullStr	Sparse representation of sounds in the unanesthetized auditory cortex.
title_full_unstemmed	Sparse representation of sounds in the unanesthetized auditory cortex.
title_sort	sparse representation of sounds in the unanesthetized auditory cortex.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/02b792a4736442309fcd601aba6e2afe
work_keys_str_mv	AT tomashromadka sparserepresentationofsoundsintheunanesthetizedauditorycortex AT michaelrdeweese sparserepresentationofsoundsintheunanesthetizedauditorycortex AT anthonymzador sparserepresentationofsoundsintheunanesthetizedauditorycortex
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Sparse representation of sounds in the unanesthetized auditory cortex.

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