Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes

Abstract Cell migration is a dynamic process that involves adhesion molecules and the deformation of the moving cell that depends on cytoskeletal remodeling and actin-modulating proteins such as myosins. In this work, we analyzed the role of the class I Myosin-1 g (Myo1g) in migratory processes of L...

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Autores principales:	D. Cruz-Zárate, O. López-Ortega, D. A. Girón-Pérez, A. M. Gonzalez-Suarez, J. L. García-Cordero, M. Schnoor, L. Santos-Argumedo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/02b8ea5efc7943298d716d4ed4d77750
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spelling	oai:doaj.org-article:02b8ea5efc7943298d716d4ed4d777502021-12-02T14:25:32ZMyo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes10.1038/s41598-021-85477-y2045-2322https://doaj.org/article/02b8ea5efc7943298d716d4ed4d777502021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85477-yhttps://doaj.org/toc/2045-2322Abstract Cell migration is a dynamic process that involves adhesion molecules and the deformation of the moving cell that depends on cytoskeletal remodeling and actin-modulating proteins such as myosins. In this work, we analyzed the role of the class I Myosin-1 g (Myo1g) in migratory processes of LPS + IL-4 activated B lymphocytes in vivo and in vitro. In vivo, the absence of Myo1g reduced homing of activated B lymphocytes into the inguinal lymph node. Using microchannel chambers and morphology analysis, we found that the lack of Myo1g caused adhesion and chemotaxis defects. Additionally, deficiency in Myo1g causes flaws in adopting a migratory morphology. Our results highlight the importance of Myo1g during B cell migration.D. Cruz-ZárateO. López-OrtegaD. A. Girón-PérezA. M. Gonzalez-SuarezJ. L. García-CorderoM. SchnoorL. Santos-ArgumedoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q D. Cruz-Zárate O. López-Ortega D. A. Girón-Pérez A. M. Gonzalez-Suarez J. L. García-Cordero M. Schnoor L. Santos-Argumedo Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes
description	Abstract Cell migration is a dynamic process that involves adhesion molecules and the deformation of the moving cell that depends on cytoskeletal remodeling and actin-modulating proteins such as myosins. In this work, we analyzed the role of the class I Myosin-1 g (Myo1g) in migratory processes of LPS + IL-4 activated B lymphocytes in vivo and in vitro. In vivo, the absence of Myo1g reduced homing of activated B lymphocytes into the inguinal lymph node. Using microchannel chambers and morphology analysis, we found that the lack of Myo1g caused adhesion and chemotaxis defects. Additionally, deficiency in Myo1g causes flaws in adopting a migratory morphology. Our results highlight the importance of Myo1g during B cell migration.
format	article
author	D. Cruz-Zárate O. López-Ortega D. A. Girón-Pérez A. M. Gonzalez-Suarez J. L. García-Cordero M. Schnoor L. Santos-Argumedo
author_facet	D. Cruz-Zárate O. López-Ortega D. A. Girón-Pérez A. M. Gonzalez-Suarez J. L. García-Cordero M. Schnoor L. Santos-Argumedo
author_sort	D. Cruz-Zárate
title	Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes
title_short	Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes
title_full	Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes
title_fullStr	Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes
title_full_unstemmed	Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes
title_sort	myo1g is required for efficient adhesion and migration of activated b lymphocytes to inguinal lymph nodes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/02b8ea5efc7943298d716d4ed4d77750
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Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes

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