Effects of multi-domain cognitive training on working memory retrieval in older adults: behavioral and ERP evidence from a Chinese community study

Abstract Working memory (WM) is a fundamental cognitive function that typically declines with age. Previous studies have shown that targeted WM training has the potential to improve WM performance in older adults. In the present study, we investigated whether a multi-domain cognitive training progra...

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Autores principales:	Xiangfei Hong, You Chen, Jijun Wang, Yuan Shen, Qingwei Li, Binglei Zhao, Xiaoli Guo, Wei Feng, Wenyuan Wu, Chunbo Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/02b9eb3428b247e4a90573d4d7a7a888
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spelling	oai:doaj.org-article:02b9eb3428b247e4a90573d4d7a7a8882021-12-02T14:12:41ZEffects of multi-domain cognitive training on working memory retrieval in older adults: behavioral and ERP evidence from a Chinese community study10.1038/s41598-020-79784-z2045-2322https://doaj.org/article/02b9eb3428b247e4a90573d4d7a7a8882021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79784-zhttps://doaj.org/toc/2045-2322Abstract Working memory (WM) is a fundamental cognitive function that typically declines with age. Previous studies have shown that targeted WM training has the potential to improve WM performance in older adults. In the present study, we investigated whether a multi-domain cognitive training program that was not designed to specifically target WM could improve the behavioral performance and affect the neural activity during WM retrieval in healthy older adults. We assigned healthy older participants (70–78 years old) from a local community into a training group who completed a 3-month multi-domain cognitive training and a control group who only attended health education lectures during the same period. Behavioral and electroencephalography (EEG) data were recorded from participants while performing an untrained delayed match or non-match to category task and a control task at a pre-training baseline session and a post-training follow-up session. Behaviorally, we found that participants in the training group showed a trend toward greater WM performance gains than participants in the control group. Event-related potential (ERP) results suggest that the task-related modulation of P3 during WM retrieval was significantly enhanced at the follow-up session compared with the baseline session, and importantly, this enhancement of P3 modulation was only significant in the training group. Furthermore, no training-related effects were observed for the P2 or N2 component during WM retrieval. These results suggest that the multi-domain cognitive training program that was not designed to specifically target WM is a promising approach to improve WM performance in older adults, and that training-related gains in performance are likely mediated by an enhanced modulation of P3 which might reflect the process of WM updating.Xiangfei HongYou ChenJijun WangYuan ShenQingwei LiBinglei ZhaoXiaoli GuoWei FengWenyuan WuChunbo LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiangfei Hong You Chen Jijun Wang Yuan Shen Qingwei Li Binglei Zhao Xiaoli Guo Wei Feng Wenyuan Wu Chunbo Li Effects of multi-domain cognitive training on working memory retrieval in older adults: behavioral and ERP evidence from a Chinese community study
description	Abstract Working memory (WM) is a fundamental cognitive function that typically declines with age. Previous studies have shown that targeted WM training has the potential to improve WM performance in older adults. In the present study, we investigated whether a multi-domain cognitive training program that was not designed to specifically target WM could improve the behavioral performance and affect the neural activity during WM retrieval in healthy older adults. We assigned healthy older participants (70–78 years old) from a local community into a training group who completed a 3-month multi-domain cognitive training and a control group who only attended health education lectures during the same period. Behavioral and electroencephalography (EEG) data were recorded from participants while performing an untrained delayed match or non-match to category task and a control task at a pre-training baseline session and a post-training follow-up session. Behaviorally, we found that participants in the training group showed a trend toward greater WM performance gains than participants in the control group. Event-related potential (ERP) results suggest that the task-related modulation of P3 during WM retrieval was significantly enhanced at the follow-up session compared with the baseline session, and importantly, this enhancement of P3 modulation was only significant in the training group. Furthermore, no training-related effects were observed for the P2 or N2 component during WM retrieval. These results suggest that the multi-domain cognitive training program that was not designed to specifically target WM is a promising approach to improve WM performance in older adults, and that training-related gains in performance are likely mediated by an enhanced modulation of P3 which might reflect the process of WM updating.
format	article
author	Xiangfei Hong You Chen Jijun Wang Yuan Shen Qingwei Li Binglei Zhao Xiaoli Guo Wei Feng Wenyuan Wu Chunbo Li
author_facet	Xiangfei Hong You Chen Jijun Wang Yuan Shen Qingwei Li Binglei Zhao Xiaoli Guo Wei Feng Wenyuan Wu Chunbo Li
author_sort	Xiangfei Hong
title	Effects of multi-domain cognitive training on working memory retrieval in older adults: behavioral and ERP evidence from a Chinese community study
title_short	Effects of multi-domain cognitive training on working memory retrieval in older adults: behavioral and ERP evidence from a Chinese community study
title_full	Effects of multi-domain cognitive training on working memory retrieval in older adults: behavioral and ERP evidence from a Chinese community study
title_fullStr	Effects of multi-domain cognitive training on working memory retrieval in older adults: behavioral and ERP evidence from a Chinese community study
title_full_unstemmed	Effects of multi-domain cognitive training on working memory retrieval in older adults: behavioral and ERP evidence from a Chinese community study
title_sort	effects of multi-domain cognitive training on working memory retrieval in older adults: behavioral and erp evidence from a chinese community study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/02b9eb3428b247e4a90573d4d7a7a888
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Effects of multi-domain cognitive training on working memory retrieval in older adults: behavioral and ERP evidence from a Chinese community study

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