Effect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder

Chunyang Pan, Yi Zhao, Haojie Xie, Yongyan Zhou, Ranran Duan, Yanfei Li, Yanjie Jia, Tao Peng Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence: Tao PengDepartment of Neurology, The First Affiliated Hospital of Zhengzh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pan C, Zhao Y, Xie H, Zhou Y, Duan R, Li Y, Jia Y, Peng T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	blood-brain barrier brainstem humoral immunity optic neuritis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/02baf05cc92c41b3b561e0a587297521
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:02baf05cc92c41b3b561e0a587297521
record_format	dspace
spelling	oai:doaj.org-article:02baf05cc92c41b3b561e0a5872975212021-12-02T19:11:49ZEffect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder1178-2021https://doaj.org/article/02baf05cc92c41b3b561e0a5872975212021-09-01T00:00:00Zhttps://www.dovepress.com/effect-of-low-complement-c4-on-clinical-characteristics-of-patients-wi-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Chunyang Pan, Yi Zhao, Haojie Xie, Yongyan Zhou, Ranran Duan, Yanfei Li, Yanjie Jia, Tao Peng Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence: Tao PengDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Erqi District, Zhengzhou, Henan Province, People’s Republic of ChinaTel +861 367 366 5072Email zdyfy0420@163.comPurpose: To describe and compare the clinical features of patients with first-episode neuromyelitis optica spectrum disorder (NMOSD) in a normal complement C4 group and a low complement C4 group, and explore the mechanism by which low complement C4 affects the clinical features of patients with NMOSD.Patients and Methods: We retrospectively analyzed clinical data of 169 aquaporin-4 (AQP4) antibody positive patients with NMOSD from the First Affiliated Hospital of Zhengzhou University from December 2013 to March 2021. Prior to treatment, the blood was drawn for detection, and the patients underwent a 3.0 Tesla MRI examination. A low complement C4 level was defined as a serum complement C4 level < 0.14 g/L. Depending on whether the complement C4 level was reduced, it was divided into the normal complement C4 group and low complement C4 group. The basic demographics, clinical manifestations, laboratory examinations, and imaging findings of the two groups were compared.Results: Among the 169 AQP4 antibody positive patients, 54 were low-complement C4 patients and 115 were normal. There were no significant differences in the demographics, clinical manifestations, treatment options, or admission Expanded Disability Status Scale (EDSS) score between two groups (P > 0.05). The median of discharged EDSS was the same (4 vs 4), but the difference between the two was statistically significant (P = 0.019). Compared with the normal complement C4 group, the blood uric acid level (225 vs 179; P = 0.001) and the C3 level (1.06 vs 0.87, P = 0.000) of the low complement C4 group were significantly lower. The incidence of brainstem lesions in patients with low complement C4 was higher (53.7% vs 33%, P = 0.01).Conclusion: The treatment effect of the first-episode AQP4 antibody positive NMOSD low complement C4 group was poor, the blood-brain barrier was more severely damaged, and the disease changes were likely to involve the brainstem.Keywords: blood-brain barrier, brainstem, humoral immunity, optic neuritisPan CZhao YXie HZhou YDuan RLi YJia YPeng TDove Medical Pressarticleblood-brain barrierbrainstemhumoral immunityoptic neuritisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2859-2866 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood-brain barrier brainstem humoral immunity optic neuritis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	blood-brain barrier brainstem humoral immunity optic neuritis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Pan C Zhao Y Xie H Zhou Y Duan R Li Y Jia Y Peng T Effect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder
description	Chunyang Pan, Yi Zhao, Haojie Xie, Yongyan Zhou, Ranran Duan, Yanfei Li, Yanjie Jia, Tao Peng Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence: Tao PengDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Erqi District, Zhengzhou, Henan Province, People’s Republic of ChinaTel +861 367 366 5072Email zdyfy0420@163.comPurpose: To describe and compare the clinical features of patients with first-episode neuromyelitis optica spectrum disorder (NMOSD) in a normal complement C4 group and a low complement C4 group, and explore the mechanism by which low complement C4 affects the clinical features of patients with NMOSD.Patients and Methods: We retrospectively analyzed clinical data of 169 aquaporin-4 (AQP4) antibody positive patients with NMOSD from the First Affiliated Hospital of Zhengzhou University from December 2013 to March 2021. Prior to treatment, the blood was drawn for detection, and the patients underwent a 3.0 Tesla MRI examination. A low complement C4 level was defined as a serum complement C4 level < 0.14 g/L. Depending on whether the complement C4 level was reduced, it was divided into the normal complement C4 group and low complement C4 group. The basic demographics, clinical manifestations, laboratory examinations, and imaging findings of the two groups were compared.Results: Among the 169 AQP4 antibody positive patients, 54 were low-complement C4 patients and 115 were normal. There were no significant differences in the demographics, clinical manifestations, treatment options, or admission Expanded Disability Status Scale (EDSS) score between two groups (P > 0.05). The median of discharged EDSS was the same (4 vs 4), but the difference between the two was statistically significant (P = 0.019). Compared with the normal complement C4 group, the blood uric acid level (225 vs 179; P = 0.001) and the C3 level (1.06 vs 0.87, P = 0.000) of the low complement C4 group were significantly lower. The incidence of brainstem lesions in patients with low complement C4 was higher (53.7% vs 33%, P = 0.01).Conclusion: The treatment effect of the first-episode AQP4 antibody positive NMOSD low complement C4 group was poor, the blood-brain barrier was more severely damaged, and the disease changes were likely to involve the brainstem.Keywords: blood-brain barrier, brainstem, humoral immunity, optic neuritis
format	article
author	Pan C Zhao Y Xie H Zhou Y Duan R Li Y Jia Y Peng T
author_facet	Pan C Zhao Y Xie H Zhou Y Duan R Li Y Jia Y Peng T
author_sort	Pan C
title	Effect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder
title_short	Effect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder
title_full	Effect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder
title_fullStr	Effect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder
title_full_unstemmed	Effect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder
title_sort	effect of low complement c4 on clinical characteristics of patients with first-episode neuromyelitis optica spectrum disorder
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/02baf05cc92c41b3b561e0a587297521
work_keys_str_mv	AT panc effectoflowcomplementc4onclinicalcharacteristicsofpatientswithfirstepisodeneuromyelitisopticaspectrumdisorder AT zhaoy effectoflowcomplementc4onclinicalcharacteristicsofpatientswithfirstepisodeneuromyelitisopticaspectrumdisorder AT xieh effectoflowcomplementc4onclinicalcharacteristicsofpatientswithfirstepisodeneuromyelitisopticaspectrumdisorder AT zhouy effectoflowcomplementc4onclinicalcharacteristicsofpatientswithfirstepisodeneuromyelitisopticaspectrumdisorder AT duanr effectoflowcomplementc4onclinicalcharacteristicsofpatientswithfirstepisodeneuromyelitisopticaspectrumdisorder AT liy effectoflowcomplementc4onclinicalcharacteristicsofpatientswithfirstepisodeneuromyelitisopticaspectrumdisorder AT jiay effectoflowcomplementc4onclinicalcharacteristicsofpatientswithfirstepisodeneuromyelitisopticaspectrumdisorder AT pengt effectoflowcomplementc4onclinicalcharacteristicsofpatientswithfirstepisodeneuromyelitisopticaspectrumdisorder
_version_	1718377068967755776

Effect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder

Ejemplares similares