Guanylate-Binding Protein-Dependent Noncanonical Inflammasome Activation Prevents <named-content content-type="genus-species">Burkholderia thailandensis</named-content>-Induced Multinucleated Giant Cell Formation

Guanylate-Binding Protein-Dependent Noncanonical Inflammasome Activation Prevents <named-content content-type="genus-species">Burkholderia thailandensis</named-content>-Induced Multinucleated Giant Cell Formation

ABSTRACT Inflammasomes are cytosolic multiprotein signaling complexes that are activated upon pattern recognition receptor-mediated recognition of pathogen-derived ligands or endogenous danger signals. Their assembly activates the downstream inflammatory caspase-1 and caspase-4/5 (human) or caspase-...

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Autores principales: Marisa Dilucca, Saray Ramos, Kateryna Shkarina, José Carlos Santos, Petr Broz
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
antimicrobial mechanisms
guanylate-binding proteins
host-pathogen interactions
inflammasomes
innate immunity
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/02bb376013384fafb53039e535537444
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